ENSDARG00000042881


Danio rerio

Features
Gene ID: ENSDARG00000042881
  
Biological name :nthl1
  
Synonyms : nthl1 / nth-like DNA glycosylase 1
  
Possible biological names infered from orthology : nth (endonuclease III)-like 1 (E.coli) / O35980 / P78549
  
Species: Danio rerio
  
Chr. number: 1
Strand: -1
Band:
Gene start: 54178703
Gene end: 54191626
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000062940
NCBI entrez gene - 100008368     See in Manteia.
swissprot - F1QBP9
ZFIN ID - ZDB-GENE-120511-4
Ensembl - ENSDARG00000042881
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NTHL1ENSGALG00000005617Gallus gallus
 NTHL1ENSG00000065057Homo sapiens
 Nthl1ENSMUSG00000041429Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000445  Helix-hairpin-helix motif
 IPR003265  HhH-GPD domain
 IPR003651  Endonuclease III-like, iron-sulphur cluster loop motif
 IPR004036  Endonuclease III-like, conserved site-2
 IPR011257  DNA glycosylase
 IPR023170  Helix-turn-helix, base-excision DNA repair, C-terminal
 IPR030841  Endonuclease III-like protein 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006284 base-excision repair IEA
 biological_processGO:0006285 base-excision repair, AP site formation IEA
 biological_processGO:0006296 nucleotide-excision repair, DNA incision, 5"-to lesion IBA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0008152 metabolic process IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005739 mitochondrion IBA
 molecular_functionGO:0000703 oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016798 hydrolase activity, acting on glycosyl bonds IEA
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0019104 DNA N-glycosylase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051536 iron-sulfur cluster binding IEA
 molecular_functionGO:0051539 4 iron, 4 sulfur cluster binding IEA
 molecular_functionGO:0140078 class I DNA-(apurinic or apyrimidinic site) endonuclease activity IEA
 molecular_functionGO:0140080 class III/IV DNA-(apurinic or apyrimidinic site) endonuclease activity IEA


Pathways (from Reactome)
Pathway description
Cleavage of the damaged pyrimidine
Displacement of DNA glycosylase by APEX1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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