ENSMUSG00000041429


Mus musculus

Features
Gene ID: ENSMUSG00000041429
  
Biological name :Nthl1
  
Synonyms : nth (endonuclease III)-like 1 (E.coli) / Nthl1 / O35980
  
Possible biological names infered from orthology : nth like DNA glycosylase 1 / P78549
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: A3.3
Gene start: 24632682
Gene end: 24638838
  
Corresponding Affymetrix probe sets: 10442542 (MoGene1.0st)   1419433_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000047413
NCBI entrez gene - 18207     See in Manteia.
MGI - MGI:1313275
RefSeq - NM_008743
RefSeq - XM_006523819
RefSeq Peptide - NP_032769
swissprot - O35980
Ensembl - ENSMUSG00000041429
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nthl1ENSDARG00000042881Danio rerio
 NTHL1ENSGALG00000005617Gallus gallus
 NTHL1ENSG00000065057Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000445  Helix-hairpin-helix motif
 IPR003265  HhH-GPD domain
 IPR003651  Endonuclease III-like, iron-sulphur cluster loop motif
 IPR004036  Endonuclease III-like, conserved site-2
 IPR011257  DNA glycosylase
 IPR023170  Helix-turn-helix, base-excision DNA repair, C-terminal
 IPR030841  Endonuclease III-like protein 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair TAS
 biological_processGO:0006284 base-excision repair IEA
 biological_processGO:0006285 base-excision repair, AP site formation ISO
 biological_processGO:0006296 nucleotide-excision repair, DNA incision, 5"-to lesion IDA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0008152 metabolic process IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005739 mitochondrion IEA
 molecular_functionGO:0000703 oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003690 double-stranded DNA binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity ISO
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016798 hydrolase activity, acting on glycosyl bonds IEA
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0019104 DNA N-glycosylase activity IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051536 iron-sulfur cluster binding IEA
 molecular_functionGO:0051539 4 iron, 4 sulfur cluster binding IEA
 molecular_functionGO:0140078 class I DNA-(apurinic or apyrimidinic site) endonuclease activity IEA
 molecular_functionGO:0140080 class III/IV DNA-(apurinic or apyrimidinic site) endonuclease activity IEA


Pathways (from Reactome)
Pathway description
Cleavage of the damaged pyrimidine
Displacement of DNA glycosylase by APEX1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0008058 abnormal DNA repair "any anomaly in the process of restoring DNA after damage or replication error" [GO:0006281]
Show

Allelic Composition: Sdc4tm1Goe/Sdc4+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Nthl1tm1Yas/Nthl1tm1Yas
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000035960 Apex1 / P28352 / DNA-(apurinic or apyrimidinic site) lyase DNA-(apurinic or apyrimidinic site) lyase, mitochondrial / P27695* / apurinic/apyrimidinic endodeoxyribonuclease 1*  / reaction






 

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