ENSDARG00000045958


Danio rerio

Features
Gene ID: ENSDARG00000045958
  
Biological name :egfl6
  
Synonyms : egfl6 / EGF-like-domain, multiple 6
  
Possible biological names infered from orthology : Epidermal growth factor-like protein 6 / Q8IUX8 / Q9JJZ5
  
Species: Danio rerio
  
Chr. number: 9
Strand: 1
Band:
Gene start: 54629993
Gene end: 54681473
  
Corresponding Affymetrix probe sets: Dr.1807.1.A1_at (Zebrafish Array)   NM_001002457_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000142045
Ensembl peptide - ENSDARP00000067543
Ensembl peptide - ENSDARP00000154776
NCBI entrez gene - 436730     See in Manteia.
RefSeq - NM_001002457
RefSeq - XM_017357664
RefSeq Peptide - NP_001002457
swissprot - F1R089
swissprot - A0A0R4IZW3
swissprot - Q6DHG1
ZFIN ID - ZDB-GENE-040718-157
Ensembl - ENSDARG00000045958
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 EGFL6ENSGALG00000016584Gallus gallus
 EGFL6ENSG00000198759Homo sapiens
 Egfl6ENSMUSG00000000402Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
npnt / nephronectin / Q6UXI9* / Q91V88*ENSDARG0000001872142
nephronectin / NPNT (1 of many) / NPNT* / Q6UXI9*ENSDARG0000010079727
si:ch211-194g2.4 / EGFL7* / Q9UHF1* / EGF like domain multiple 7*ENSDARG0000009464816
egfl7 / EGF-like-domain, multiple 7 / Q9UHF1*ENSDARG0000010065712


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000742  EGF-like domain
 IPR000998  MAM domain
 IPR001881  EGF-like calcium-binding domain
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR013032  EGF-like, conserved site
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR018097  EGF-like calcium-binding, conserved site
 IPR032930  Epidermal growth factor-like protein 6


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008593 regulation of Notch signaling pathway IMP
 biological_processGO:0030198 extracellular matrix organization IEA
 biological_processGO:0030903 notochord development IMP
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0005509 calcium ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000135 notochord notochord deformed , abnormal
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 ZFA:0001094 whole organism whole organism decreased amount , abnormal
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 ZFA:0001115 trunk trunk curved , abnormal
trunk increased amount , abnormal
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 ZFA:0001285 intersegmental vessel intersegmental vessel decreased length , abnormal
intersegmental vessel endothelial tip cell has fewer parts of type endothelial tip cell filopodium, abnormal
intersegmental vessel decreased length , ameliorated
intersegmental vessel endothelial cell amount , ameliorated
intersegmental vessel endothelial cell decreased amount , abnormal
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 ZFA:0005025 dorsal longitudinal anastomotic vessel dorsal longitudinal anastomotic vessel blood vessel morphogenesis decreased occurrence , abnormal
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 ZFA:0009303 endothelial tip cell endothelial tip cell filopodium decreased amount , abnormal
endothelial tip cell cell migration involved in sprouting angiogenesis decreased rate , abnormal
endothelial tip cell cell division decreased occurrence , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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