ENSDARG00000052113


Danio rerio

Features
Gene ID: ENSDARG00000052113
  
Biological name :hexa
  
Synonyms : hexa / hexosaminidase A (alpha polypeptide)
  
Possible biological names infered from orthology : AC009690.1 / Beta-hexosaminidase subunit alpha / hexosaminidase subunit alpha / P06865 / P29416
  
Species: Danio rerio
  
Chr. number: 25
Strand: 1
Band:
Gene start: 22216723
Gene end: 22241312
  
Corresponding Affymetrix probe sets: Dr.17343.1.S1_at (Zebrafish Array)   NM_001017763_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000051290
NCBI entrez gene - 550460     See in Manteia.
RefSeq - NM_001017763
RefSeq Peptide - NP_001017763
swissprot - F1RDQ5
ZFIN ID - ZDB-GENE-050417-283
Ensembl - ENSDARG00000052113
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 HEXAENSGALG00000043828Gallus gallus
 AC009690.1ENSG00000260729Homo sapiens
 HEXAENSG00000213614Homo sapiens
 HexaENSMUSG00000025232Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
hexb / hexosaminidase B (beta polypeptide) / P07686* / P20060* / hexosaminidase subunit beta* / Beta-hexosaminidase subunit beta *ENSDARG0000003436855


Protein motifs (from Interpro)
Interpro ID Name
 IPR015883  Glycoside hydrolase family 20, catalytic domain
 IPR017853  Glycoside hydrolase superfamily
 IPR025705  Beta-hexosaminidase
 IPR029018  Beta-hexosaminidase-like, domain 2
 IPR029019  Beta-hexosaminidase, eukaryotic type, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0008152 metabolic process IEA
 cellular_componentGO:0005575 cellular_component ND
 molecular_functionGO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds IEA
 molecular_functionGO:0004563 beta-N-acetylhexosaminidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016798 hydrolase activity, acting on glycosyl bonds IEA
 molecular_functionGO:0102148 N-acetyl-beta-D-galactosaminidase activity IEA


Pathways (from Reactome)
Pathway description
Glycosphingolipid metabolism
Keratan sulfate degradation
CS/DS degradation
Hyaluronan uptake and degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0009141 macrophage macrophage morphology , abnormal
macrophage lysosome accumulation macrophage , abnormal
macrophage myeloid leukocyte migration process quality , abnormal
macrophage myeloid leukocyte migration decreased process quality , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000088439 gm2a / GM2 ganglioside activator / P17900*  / reaction
 ENSDARG00000107431 LO018208.1 / GM2A* / P17900* / GM2 ganglioside activator*  / reaction
 ENSDARG00000034368 hexb / hexosaminidase B (beta polypeptide) / P07686* / P20060* / hexosaminidase subunit beta* / Beta-hexosaminidase subunit beta *  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr