ENSDARG00000034368


Danio rerio

Features
Gene ID: ENSDARG00000034368
  
Biological name :hexb
  
Synonyms : hexb / hexosaminidase B (beta polypeptide)
  
Possible biological names infered from orthology : Beta-hexosaminidase subunit beta / hexosaminidase subunit beta / P07686 / P20060
  
Species: Danio rerio
  
Chr. number: 5
Strand: -1
Band:
Gene start: 34600714
Gene end: 34616599
  
Corresponding Affymetrix probe sets: Dr.18068.1.A1_at (Zebrafish Array)   Dr.5384.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000113789
Ensembl peptide - ENSDARP00000050270
Ensembl peptide - ENSDARP00000088748
NCBI entrez gene - 323613     See in Manteia.
RefSeq - NM_001309863
RefSeq - XM_009301448
RefSeq Peptide - NP_001296792
RefSeq Peptide - NP_001108317
swissprot - F1QUU0
swissprot - A2BHD8
swissprot - F1QTE2
ZFIN ID - ZDB-GENE-030131-2333
Ensembl - ENSDARG00000034368
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 HEXBENSGALG00000014933Gallus gallus
 HEXBENSG00000049860Homo sapiens
 HexbENSMUSG00000021665Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
hexa / hexosaminidase A (alpha polypeptide) / P29416* / P06865* / AC009690.1* / hexosaminidase subunit alpha* / Beta-hexosaminidase subunit alpha *ENSDARG0000005211355


Protein motifs (from Interpro)
Interpro ID Name
 IPR015883  Glycoside hydrolase family 20, catalytic domain
 IPR017853  Glycoside hydrolase superfamily
 IPR025705  Beta-hexosaminidase
 IPR029018  Beta-hexosaminidase-like, domain 2
 IPR029019  Beta-hexosaminidase, eukaryotic type, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IMP
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0008152 metabolic process IEA
 molecular_functionGO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds IEA
 molecular_functionGO:0004563 beta-N-acetylhexosaminidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016798 hydrolase activity, acting on glycosyl bonds IEA
 molecular_functionGO:0102148 N-acetyl-beta-D-galactosaminidase activity IEA


Pathways (from Reactome)
Pathway description
Glycosphingolipid metabolism
Keratan sulfate degradation
CS/DS degradation
Hyaluronan uptake and degradation
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000084 yolk yolk edematous , abnormal
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 ZFA:0000106 extension extension distended , abnormal
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 ZFA:0001079 blood vasculature blood vasculature broken , abnormal
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 ZFA:0001094 whole organism whole organism curved ventral , abnormal
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 ZFA:0001114 head head decreased size , abnormal
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 ZFA:0001285 intersegmental vessel intersegmental vessel morphology , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000052113 hexa / hexosaminidase A (alpha polypeptide) / P29416* / P06865* / AC009690.1* / hexosaminidase subunit alpha* / Beta-hexosaminidase subunit alpha *  / complex
 ENSDARG00000034368 hexb / hexosaminidase B (beta polypeptide) / P07686* / P20060* / hexosaminidase subunit beta* / Beta-hexosaminidase subunit beta *  / complex
 ENSDARG00000107431 LO018208.1 / GM2A* / P17900* / GM2 ganglioside activator*  / reaction
 ENSDARG00000088439 gm2a / GM2 ganglioside activator / P17900*  / reaction






 

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