Manteia

ID	Phenotype	Definition	Genetic BG
MP:0000130	abnormal cancellous bone morphology	"structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Hexa^tm1Rlp/Hexa^tm1Rlp,Hexb^tm1Rlp/Hexb^tm1Rlp Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0000137	abnormal vertebrae morphology	"malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Hexa^tm1Rlp/Hexa^tm1Rlp,Hexb^tm1Rlp/Hexb^tm1Rlp Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0000150	abnormal rib morphology	"malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]	Show Allelic Composition: Hexa^tm1Rlp/Hexa^tm1Rlp,Hexb^tm1Rlp/Hexb^tm1Rlp Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0000160	kyphosis	"forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]	Show Allelic Composition: Hexa^tm1Rlp/Hexa^tm1Rlp,Hexb^tm1Rlp/Hexb^tm1Rlp Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0000242	impaired fertilization	"defect or reduced ability in the process beginning with penetration of the secondary oocyte by the spermatozoon and completed by fusion of the male and female pronucei" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Hexb^tm1Grv/Hexb^tm1Grv Genetic Background: either: (involves: 129P2/Ola * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * C57L/6J)
MP:0000435	shortened head	"reduced anterior-posterior length of the head" [J:42035]	Show Allelic Composition: Hexa^tm1Rlp/Hexa^tm1Rlp,Hexb^tm1Rlp/Hexb^tm1Rlp Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0000438	abnormal skull morphology	"anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Hexa^tm1Rlp/Hexa^tm1Rlp,Hexb^tm1Rlp/Hexb^tm1Rlp Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0000458	abnormal mandible morphology	"malformation of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Hexa^tm1Rlp/Hexa^tm1Rlp,Hexb^tm1Rlp/Hexb^tm1Rlp Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0000598	abnormal liver morphology	"malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]	Show Allelic Composition: Foxa2^tm1Khk/Foxa2^tm1Khk,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA
MP:0000607	abnormal hepatocyte morphology	"malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Foxa2^tm1Khk/Foxa2^tm1Khk,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA
MP:0000745	tremors	"repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Foxa2^tm1Khk/Foxa2^tm1Khk,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA Allelic Composition: Hexb^tm1Grv/Hexb^tm1Grv Genetic Background: either: (involves: 129P2/Ola * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * C57L/6J) Allelic Composition: Hexb^tm1Rlp/Hexb^tm1Rlp,Tg(Hexb-tTA2S,tetO-Hexb)#Tjsa/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA Allelic Composition: Hexb^tm1Rlp/Hexb^tm1Rlp,Tg(SYN1-tTA2S,tetO-Hexb)#Tjsa/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA Allelic Composition: Hexb^mpc191H/Hexb^mpc191H Genetic Background: involves: BALB/c * C3H/HeH * C57BL/6J
MP:0000747	muscle weakness	"loss of muscle strength" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Hexb^tm1Grv/Hexb^tm1Grv Genetic Background: either: (involves: 129P2/Ola * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * C57L/6J)
MP:0000755	hindlimb paralysis	"loss of power of voluntary movement in the muscles of the hindlimb through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Hexb^tm1Grv/Hexb^tm1Grv Genetic Background: either: (involves: 129P2/Ola * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * C57L/6J)
MP:0000876	Purkinje cell degeneration	"a retrogressive impairment of function or destruction of the large neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex" [J:46854]	Show Allelic Composition: B4galnt1^tm1Rlp/B4galnt1^tm1Rlp,Hexb^tm1Rlp/Hexb^tm1Rlp Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 Allelic Composition: Hexb^tm1Rlp/Hexb^tm1Rlp Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
MP:0000877	abnormal Purkinje cell	"any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells" [J:46140, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: B4galnt1^tm1Rlp/B4galnt1^tm1Rlp,Hexb^tm1Rlp/Hexb^tm1Rlp Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6
MP:0000920	abnormal myelination	"atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Hexa^tm1Rlp/Hexa^tm1Rlp,Hexb^tm1Rlp/Hexb^tm1Rlp Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0000951	sporadic seizures	"occasional seizures occuring at irregular intervals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Hexa^tm1Rlp/Hexa^tm1Rlp,Hexb^tm1Rlp/Hexb^tm1Rlp Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0000952	abnormal CNS glia	"anomalous structure, number or composition of non-neuronal cells of the central nervous system that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Hexa^tm1Rlp/Hexa^tm1Rlp,Hexb^tm1Rlp/Hexb^tm1Rlp Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0000955	abnormal spinal cord morphology	"malformation or disorganization of the cylindrical tissue of the vertebral canal that extends from the medulla oblongata to the conus medullaris" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Hexb^tm1Grv/Hexb^tm1Grv Genetic Background: either: (involves: 129P2/Ola * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * C57L/6J)
MP:0001154	seminiferous tubule degeneration	"a retrogressive impairment of function or destruction of the tubules in the testes where spermatogenesis occurs" [J:50844]	Show Allelic Composition: B4galnt1^tm1Rlp/B4galnt1^tm1Rlp,Hexb^tm1Rlp/Hexb^tm1Rlp Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6
MP:0001263	weight loss	"progressive reduction of body weight below normal average for age" [J:45400]	Show Allelic Composition: Foxa2^tm1Khk/Foxa2^tm1Khk,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA Allelic Composition: Hexb^tm1Rlp/Hexb^tm1Rlp,Tg(Hexb-tTA2S,tetO-Hexb)#Tjsa/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA Allelic Composition: Hexb^tm1Rlp/Hexb^tm1Rlp,Tg(SYN1-tTA2S,tetO-Hexb)#Tjsa/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA
MP:0001314	corneal opacity	"complete or partial clouding of the cornea" [jte:Janan T. Eppig , Mouse Genome Informatics, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Hexa^tm1Rlp/Hexa^tm1Rlp,Hexb^tm1Rlp/Hexb^tm1Rlp Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0001393	ataxia	"inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]	Show Allelic Composition: Hexb^tm1Grv/Hexb^tm1Grv Genetic Background: either: (involves: 129P2/Ola * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * C57L/6J) Allelic Composition: B4galnt1^tm1Rlp/B4galnt1^tm1Rlp,Hexb^tm1Rlp/Hexb^tm1Rlp Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6
MP:0001402	hypoactivity	"reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]	Show Allelic Composition: Hexa^tm1Rlp/Hexa^tm1Rlp,Hexb^tm1Rlp/Hexb^tm1Rlp Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Hexb^tm1Rlp/Hexb^tm1Rlp Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
MP:0001405	impaired coordination	"reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Foxa2^tm1Khk/Foxa2^tm1Khk,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA Allelic Composition: Hexa^tm1Rlp/Hexa^tm1Rlp,Hexb^tm1Rlp/Hexb^tm1Rlp Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: B4galnt1^tm1Rlp/B4galnt1^tm1Rlp,Hexb^tm1Rlp/Hexb^tm1Rlp Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 Allelic Composition: B4galnt1^tm1Rlp/B4galnt1⁺,Hexb^tm1Rlp/Hexb^tm1Rlp Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 Allelic Composition: Fcer1g^tm1Rav/Fcer1g^tm1Rav,Hexb^tm1Rlp/Hexb^tm1Rlp Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
MP:0001406	abnormal gait	"unusual or distinctive way of walking" [J:65038]	Show Allelic Composition: Foxa2^tm1Khk/Foxa2^tm1Khk,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA
MP:0001504	abnormal posture	"atypical position of the limbs or carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]	Show Allelic Composition: Hexb^tm1Rlp/Hexb^tm1Rlp Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
MP:0001513	limb grasping	"mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]	Show Allelic Composition: Hexb^tm1Rlp/Hexb^tm1Rlp Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
MP:0001516	abnormal motor coordination/ balance	"altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ccl3^tm1Unc/Ccl3^tm1Unc,Hexb^tm1Rlp/Hexb^tm1Rlp Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 Allelic Composition: Ccl3^tm1Unc/Ccl3⁺,Hexb^tm1Rlp/Hexb^tm1Rlp Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
MP:0001523	impaired righting response	"reduced ability or greater amount of time needed to recover from supine position" [J:25565]	Show Allelic Composition: Foxa2^tm1Khk/Foxa2^tm1Khk,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA Allelic Composition: B4galnt1^tm1Rlp/B4galnt1⁺,Hexb^tm1Rlp/Hexb^tm1Rlp Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6
MP:0001524	impaired limb coordination	"reduced ability to organize limb movements to execute complex maneuvers, such as walking" [J:64962, MGI:CLS, J:17123]	Show Allelic Composition: Hexb^tm1Rlp/Hexb^tm1Rlp,Tg(Hexb-tTA2S,tetO-Hexb)#Tjsa/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA Allelic Composition: Hexb^tm1Rlp/Hexb^tm1Rlp,Tg(SYN1-tTA2S,tetO-Hexb)#Tjsa/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA
MP:0001547	abnormal lipid level	"anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Fcer1g^tm1Rav/Fcer1g^tm1Rav,Hexb^tm1Rlp/Hexb^tm1Rlp Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
MP:0001650	electrically induced seizures	"high or low frequency electrical stimulation applied to induce seizure activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, wf:Wayne Frankel , TJL staff]	Show Allelic Composition: Hexb^tm1Grv/Hexb^tm1Grv Genetic Background: either: (involves: 129P2/Ola * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * C57L/6J)
MP:0001732	postnatal growth retardation	"slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Hexa^tm1Rlp/Hexa^tm1Rlp,Hexb^tm1Rlp/Hexb^tm1Rlp Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0001924	infertility	"inability to produce live offspring" [J:47225]	Show Allelic Composition: Hexa^tm1Rlp/Hexa^tm1Rlp,Hexb^tm1Rlp/Hexb^tm1Rlp Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0001967	deafness	"inability to hear" [J:57651]	Show Allelic Composition: Hexa^tm1Rlp/Hexa^tm1Rlp,Hexb^tm1Rlp/Hexb^tm1Rlp Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0002066	abnormal motor capabilities/coordination/movement	"altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Foxa2^tm1Khk/Foxa2^tm1Khk,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA Allelic Composition: Hexa^tm1Rlp/Hexa^tm1Rlp,Hexb^tm1Rlp/Hexb^tm1Rlp Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Hexb^tm1Rlp/Hexb^tm1Rlp,Tg(Hexb-tTA2S,tetO-Hexb)#Tjsa/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA Allelic Composition: Hexb^tm1Rlp/Hexb^tm1Rlp,Tg(SYN1-tTA2S,tetO-Hexb)#Tjsa/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Foxa2^tm1Khk/Foxa2^tm1Khk,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA Allelic Composition: Hexa^tm1Rlp/Hexa^tm1Rlp,Hexb^tm1Rlp/Hexb^tm1Rlp Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Hexb^tm1Grv/Hexb^tm1Grv Genetic Background: either: (involves: 129P2/Ola * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * C57L/6J) Allelic Composition: Hexb^tm1Rlp/Hexb⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Fcer1g^tm1Rav/Fcer1g^tm1Rav,Hexb^tm1Rlp/Hexb^tm1Rlp Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 Allelic Composition: Hexb^tm1Rlp/Hexb^tm1Rlp Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 Allelic Composition: Ccl3^tm1Unc/Ccl3^tm1Unc,Hexb^tm1Rlp/Hexb^tm1Rlp Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 Allelic Composition: Ccl3^tm1Unc/Ccl3⁺,Hexb^tm1Rlp/Hexb^tm1Rlp Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 Allelic Composition: Hexb^tm1Rlp/Hexb^tm1Rlp,Tg(Hexb-tTA2S,tetO-Hexb)#Tjsa/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA Allelic Composition: Hexb^tm1Rlp/Hexb^tm1Rlp,Tg(SYN1-tTA2S,tetO-Hexb)#Tjsa/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA
MP:0002092	abnormal eye morphology	"abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Hexa^tm1Rlp/Hexa^tm1Rlp,Hexb^tm1Rlp/Hexb^tm1Rlp Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0002110	abnormal digit morphology	"abnormal development of the digits resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Hexa^tm1Rlp/Hexa^tm1Rlp,Hexb^tm1Rlp/Hexb^tm1Rlp Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0002114	abnormal axial skeleton morphology	"abnormal development of vertebral, spinal or sternal bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Hexa^tm1Rlp/Hexa^tm1Rlp,Hexb^tm1Rlp/Hexb^tm1Rlp Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0002152	abnormal brain morphology	"anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]	Show Allelic Composition: Hexb^tm1Rlp/Hexb^tm1Rlp,Tg(Hexb-tTA2S,tetO-Hexb)#Tjsa/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA Allelic Composition: Hexb^tm1Rlp/Hexb^tm1Rlp,Tg(SYN1-tTA2S,tetO-Hexb)#Tjsa/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA
MP:0002161	abnormal fertility/fecundity	"reduced ability or inability to produce live offspring" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Hexb^tm1Grv/Hexb^tm1Grv Genetic Background: either: (involves: 129P2/Ola * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * C57L/6J)
MP:0002269	muscular atrophy	"a wasting of muscle tissue resulting in a derangement of the muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]	Show Allelic Composition: Foxa2^tm1Khk/Foxa2^tm1Khk,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA Allelic Composition: Hexb^tm1Rlp/Hexb^tm1Rlp Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
MP:0002446	abnormal macrophage morphology	"anomalous structure, number, or composition of the large mononuclear phagocytic cells found in most tissues of the body" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: B4galnt1^tm1Rlp/B4galnt1^tm1Rlp,Hexb^tm1Rlp/Hexb^tm1Rlp Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6
MP:0002461	increased circulating immunoglobulin concentration	"greater than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Fcer1g^tm1Rav/Fcer1g^tm1Rav,Hexb^tm1Rlp/Hexb^tm1Rlp Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 Allelic Composition: Hexb^tm1Rlp/Hexb^tm1Rlp Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
MP:0002566	abnormal sexual interaction	"altered initiation, failure of initiation or incomplete mating behavior" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Hexa^tm1Grv/Hexa^tm1Grv Genetic Background: involves: 129P2/Ola * C57BL/6J
MP:0002631	abnormal epididymis morphology	"malformation of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Hexb^tm1Grv/Hexb^tm1Grv Genetic Background: either: (involves: 129P2/Ola * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * C57L/6J)
MP:0002757	reduced vertical activity	"lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Hexa^tm1Rlp/Hexa^tm1Rlp,Hexb^tm1Rlp/Hexb^tm1Rlp Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0002862	altered righting response	"altered ability or changed amount of time needed to recover from supine position" [hdene:Howard Dene , Mouse Genome Informatics Curator]	Show Allelic Composition: Ccl3^tm1Unc/Ccl3^tm1Unc,Hexb^tm1Rlp/Hexb^tm1Rlp Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 Allelic Composition: Ccl3^tm1Unc/Ccl3⁺,Hexb^tm1Rlp/Hexb^tm1Rlp Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
MP:0002882	abnormal neuron	"anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]	Show Allelic Composition: Foxa2^tm1Khk/Foxa2^tm1Khk,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA Allelic Composition: Hexa^tm1Rlp/Hexa^tm1Rlp,Hexb^tm1Rlp/Hexb^tm1Rlp Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: B4galnt1^tm1Rlp/B4galnt1^tm1Rlp,Hexb^tm1Rlp/Hexb^tm1Rlp Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6
MP:0003632	abnormal nervous system morphology		Show Allelic Composition: Hexa^tm1Rlp/Hexa^tm1Rlp,Hexb^tm1Rlp/Hexb^tm1Rlp Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0003633	abnormal nervous system physiology		Show Allelic Composition: Hexa^tm1Rlp/Hexa^tm1Rlp,Hexb^tm1Rlp/Hexb^tm1Rlp Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Hexb^tm1Grv/Hexb^tm1Grv Genetic Background: either: (involves: 129P2/Ola * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * C57L/6J)
MP:0003807	camptodactyly	"permanant flexion of one or more digits; contractures may also be seen in the wrists and at the elbows" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Hexa^tm1Rlp/Hexa^tm1Rlp,Hexb^tm1Rlp/Hexb^tm1Rlp Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0004100	abnormal spinal cord interneuron morphology	"malformation or absence of neurons that exclusively interact with other neurons in the spinal cord" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Hexb^tm1Rlp/Hexb^tm1Rlp,Tg(Hexb-tTA2S,tetO-Hexb)#Tjsa/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA
MP:0004143	hypertonia	"increased muscle tone" [hdene:Howard Dene , Mouse Genome Informatics Curator]	Show Allelic Composition: Hexb^tm1Rlp/Hexb^tm1Rlp,Tg(Hexb-tTA2S,tetO-Hexb)#Tjsa/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA Allelic Composition: Hexb^tm1Rlp/Hexb^tm1Rlp,Tg(SYN1-tTA2S,tetO-Hexb)#Tjsa/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA
MP:0004676	wide ribs	"an increase in the width of the bones forming the bony wall of the chest" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Hexa^tm1Rlp/Hexa^tm1Rlp,Hexb^tm1Rlp/Hexb^tm1Rlp Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0004686	decreased length of long bones	"reduced end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hexa^tm1Rlp/Hexa^tm1Rlp,Hexb^tm1Rlp/Hexb^tm1Rlp Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0004728	abnormal efferent ductules of testis	"any structural abnormality in the small seminal ducts that lead from the testis to the head of the epididymis" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hexb^tm1Grv/Hexb^tm1Grv Genetic Background: either: (involves: 129P2/Ola * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * C57L/6J)
MP:0004756	abnormal proximal convoluted tubule morphology	"any structural anomaly of the convoluted portion of the duct system of the nephron that extends from the renal glomeurlar capsule in the kidney cortex into the kidney medulla where it joins the loop of Henle; fluid entering the proximal convoluted tubule is reabsorbed into the peritubular capillaries, including approximately two-thirds of the filtered salt and water and all filtered organic solutes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Foxa2^tm1Khk/Foxa2^tm1Khk,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA
MP:0004928	increased epididymis weight	"increase in the average weight of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hexb^tm1Grv/Hexb^tm1Grv Genetic Background: either: (involves: 129P2/Ola * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * C57L/6J)
MP:0005156	bradykinesia	"decreased spontaneity and movement" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83301]	Show Allelic Composition: Foxa2^tm1Khk/Foxa2^tm1Khk,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA Allelic Composition: Hexb^tm1Rlp/Hexb^tm1Rlp,Tg(Hexb-tTA2S,tetO-Hexb)#Tjsa/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA Allelic Composition: Hexb^tm1Rlp/Hexb^tm1Rlp,Tg(SYN1-tTA2S,tetO-Hexb)#Tjsa/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA
MP:0005202	lethargy	"mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Hexb^tm1Grv/Hexb^tm1Grv Genetic Background: either: (involves: 129P2/Ola * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * C57L/6J)
MP:0006043	decreased apoptosis	"less than normal cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Fcer1g^tm1Rav/Fcer1g^tm1Rav,Hexb^tm1Rlp/Hexb^tm1Rlp Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
MP:0006082	CNS inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the brain and/or spinal cord" [smb:Susan M Bello, Mouse Genome Informatics Curator, ncbi:NCBI request]	Show Allelic Composition: Hexb^tm1Rlp/Hexb^tm1Rlp Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 Allelic Composition: Ccl3^tm1Unc/Ccl3^tm1Unc,Hexb^tm1Rlp/Hexb^tm1Rlp Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
MP:0008151	increased diameter of long bones	"increased width of the cross-sectional distance that extends from one lateral edge of a long bone, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hexa^tm1Rlp/Hexa^tm1Rlp,Hexb^tm1Rlp/Hexb^tm1Rlp Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0008602	increased circulating interleukin-4 level	"increase in the amount in the blood of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]	Show Allelic Composition: Hexb^tm1Rlp/Hexb^tm1Rlp Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
MP:0008752	abnormal tumor necrosis factor level	"deviation from the normal levels of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [MESH:D12.644.276.374.500.800]	Show Allelic Composition: Ccl3^tm1Unc/Ccl3^tm1Unc,Hexb^tm1Rlp/Hexb^tm1Rlp Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
MP:0008918	microgliosis	"a proliferation or spread of microglia in the area of a degenerative lesion or damaged tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hexb^tm1Rlp/Hexb^tm1Rlp,Tg(Hexb-tTA2S,tetO-Hexb)#Tjsa/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA Allelic Composition: Hexb^tm1Rlp/Hexb^tm1Rlp,Tg(SYN1-tTA2S,tetO-Hexb)#Tjsa/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA
MP:0009249	enlarged caput	"increase in the average size of the head of the epididymis" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hexb^tm1Grv/Hexb^tm1Grv Genetic Background: either: (involves: 129P2/Ola * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * C57L/6J)
MP:0009256	enlarged corpus	"increase in the average size of the body of the epididymis" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hexb^tm1Grv/Hexb^tm1Grv Genetic Background: either: (involves: 129P2/Ola * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * C57L/6J)
MP:0009640	abnormal renal tubule epithelium morphology	"any structural anomaly of the cellular avascular layer of the renal tubule luminar surfaces" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: B4galnt1^tm1Rlp/B4galnt1^tm1Rlp,Hexb^tm1Rlp/Hexb^tm1Rlp Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6
MP:0009643	abnormal urine homeostasis	"anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hexa^tm1Rlp/Hexa^tm1Rlp,Hexb^tm1Rlp/Hexb^tm1Rlp Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0010025	decreased total body fat amount	"less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hexb^tm1Rlp/Hexb^tm1Rlp Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
MP:0010099	abnormal thoracic cage shape	"anomaly in the overall regular dome shape of the ribcage" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hexa^tm1Rlp/Hexa^tm1Rlp,Hexb^tm1Rlp/Hexb^tm1Rlp Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0011473	increased urine glycosaminoglycan level	"greater in the amount of glycosaminoglycan in the urine, including chondroitin sulfate, dermatan sulfate, keratan sulfate, heparin sulfate, heparin, and/or hyaluronan and other long unbranched polysaccharides consisting of a repeating disaccharide unit" [MGI:csmith]	Show Allelic Composition: Hexa^tm1Rlp/Hexa^tm1Rlp,Hexb^tm1Rlp/Hexb^tm1Rlp Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0012504	increased forebrain apoptosis	"increase in the number of cells of the forebrain undergoing programmed cell death" [MGI:anna]	Show Allelic Composition: Hexb^tm1Rlp/Hexb^tm1Rlp Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
MP:0030189	broad snout	"increased width of the anterior facial part of the face or muzzle containing the oral and nasal regions" [MGI:anna]	Show Allelic Composition: Hexa^tm1Rlp/Hexa^tm1Rlp,Hexb^tm1Rlp/Hexb^tm1Rlp Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0030262	frontal bossing	"bilateral bulging of the lateral frontal bone prominences with relative sparing of the midline; this is not the same as prominent forehead" [HP:0002007, PMID:19125436]	Show Allelic Composition: Hexa^tm1Rlp/Hexa^tm1Rlp,Hexb^tm1Rlp/Hexb^tm1Rlp Genetic Background: involves: 129S4/SvJae * C57BL/6

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr

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