ENSDARG00000062262


Danio rerio

Features
Gene ID: ENSDARG00000062262
  
Biological name :ednrab
  
Synonyms : ednrab / endothelin receptor type Ab
  
Possible biological names infered from orthology : EDNRA / Endothelin-1 receptor / endothelin receptor type A / P25101 / Q61614
  
Species: Danio rerio
  
Chr. number: 23
Strand: -1
Band:
Gene start: 45694055
Gene end: 45705525
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000124118
NCBI entrez gene - 405866     See in Manteia.
RefSeq - XM_021469773
RefSeq - XM_021469774
RefSeq - NM_001310095
RefSeq Peptide - NP_001297024
swissprot - F8W4W1
ZFIN ID - ZDB-GENE-040426-2364
Ensembl - ENSDARG00000062262
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 EDNRAENSGALG00000010013Gallus gallus
 EDNRAENSG00000151617Homo sapiens
 EdnraENSMUSG00000031616Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ednraa / endothelin receptor type Aa / EDNRA* / P25101* / Q61614* / Endothelin-1 receptor * / endothelin receptor type A*ENSDARG0000001187667
ednrba / endothelin receptor Ba / EDNRB* / P24530* / endothelin receptor type B*ENSDARG0000008933452
ednrbb / endothelin receptor type Bb / EDNRB* / P24530* / P48302* / endothelin receptor type B*ENSDARG0000005349840
grpr / gastrin-releasing peptide receptor / P21729* / P30550*ENSDARG0000005662025
nmbr / neuromedin B receptor / O54799* / P28336*ENSDARG0000005415225
gpr37b / G protein-coupled receptor 37b / GPR37* / O15354* / Q9QY42* / Prosaposin receptor GPR37 * / G protein-coupled receptor 37*ENSDARG0000003329624
gpr37l1a / G protein-coupled receptor 37 like 1a / Q99JG2* / O60883* / GPR37L1* / G protein-coupled receptor 37 like 1*ENSDARG0000000607924
gpr37a / G protein-coupled receptor 37a / GPR37* / O15354* / Q9QY42* / Prosaposin receptor GPR37 * / G protein-coupled receptor 37*ENSDARG0000007456323
gpr37l1b / G protein-coupled receptor 37 like 1b / Q99JG2* / O60883* / GPR37L1* / G protein-coupled receptor 37 like 1*ENSDARG0000005677421


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000499  Endothelin receptor family
 IPR002175  Endothelin receptor A
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003319 cardioblast migration to the midline involved in heart rudiment formation IGI
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0008217 regulation of blood pressure IEA
 biological_processGO:0042310 vasoconstriction IEA
 biological_processGO:0048484 enteric nervous system development IEA
 biological_processGO:0048703 embryonic viscerocranium morphogenesis IGI
 biological_processGO:0051216 cartilage development IGI
 biological_processGO:0086100 endothelin receptor signaling pathway IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004962 endothelin receptor activity IEA


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
G alpha (q) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000360 heart tube heart tube increased amount , abnormal
heart tube mislocalised laterally , abnormal
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 ZFA:0001205 Meckel s cartilage Meckels cartilage decreased size , abnormal
Meckels cartilage absent , abnormal
Meckels cartilage decreased length , abnormal
Meckels cartilage fused with ceratohyal cartilage , abnormal
Meckels cartilage ventral region fused with palatoquadrate cartilage dorsal region, abnormal
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 ZFA:0001227 mandibular arch skeleton mandibular arch skeleton cartilage development disrupted , abnormal
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 ZFA:0001273 ventral mandibular arch ventral mandibular arch aplastic , abnormal
ventral mandibular arch disorganized , abnormal
ventral mandibular arch decreased length , abnormal
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 ZFA:0001400 ceratohyal cartilage ceratohyal cartilage aplastic , abnormal
ceratohyal cartilage hypoplastic , abnormal
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 ZFA:0001422 hyosymplectic cartilage hyosymplectic cartilage dorsal region fused with ceratohyal cartilage ventral region, abnormal
Show

 ZFA:0001511 interhyal cartilage interhyal cartilage aplastic , abnormal
Show

 ZFA:0001612 pharyngeal arch 1 pharyngeal arch 1 decreased length , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000070578 edn2 / endothelin 2 / P20800* / P22389*  / reaction / complex
 ENSDARG00000086669 edn3b / endothelin 3b / EDN3* / P14138* / P48299* / endothelin 3*  / reaction / complex






 

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