ENSDARG00000068006


Danio rerio

Features
Gene ID: ENSDARG00000068006
  
Biological name :gck
  
Synonyms : gck / glucokinase (hexokinase 4)
  
Possible biological names infered from orthology : glucokinase / P35557 / P52792
  
Species: Danio rerio
  
Chr. number: 8
Strand: 1
Band:
Gene start: 40476811
Gene end: 40490593
  
Corresponding Affymetrix probe sets: Dr.23443.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000079994
Ensembl peptide - ENSDARP00000112428
NCBI entrez gene - 751668     See in Manteia.
swissprot - B8A4K2
swissprot - F1RC38
ZFIN ID - ZDB-GENE-060825-204
Ensembl - ENSDARG00000068006
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000031359Gallus gallus
 GCKENSG00000106633Homo sapiens
 GckENSMUSG00000041798Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
hk2 / hexokinase 2 / P52789*ENSDARG0000010148256
hk1 / hexokinase 1 / P17710* / P19367*ENSDARG0000003945252
hkdc1 / hexokinase domain containing 1 / Q2TB90* / Q91W97* / Putative hexokinase HKDC1 *ENSDARG0000003870351


Protein motifs (from Interpro)
Interpro ID Name
 IPR001312  Hexokinase
 IPR019807  Hexokinase, binding site
 IPR022672  Hexokinase, N-terminal
 IPR022673  Hexokinase, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001678 cellular glucose homeostasis IBA
 biological_processGO:0003323 type B pancreatic cell development IMP
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0006096 glycolytic process IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0031018 endocrine pancreas development IMP
 biological_processGO:0042593 glucose homeostasis IMP
 biological_processGO:0046835 carbohydrate phosphorylation IEA
 biological_processGO:0050796 regulation of insulin secretion IBA
 biological_processGO:0051156 glucose 6-phosphate metabolic process IEA
 biological_processGO:1990798 pancreas regeneration IMP
 cellular_componentGO:0005623 cell IEA
 cellular_componentGO:0005829 cytosol IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004340 glucokinase activity IBA
 molecular_functionGO:0004396 hexokinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0005536 glucose binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016773 phosphotransferase activity, alcohol group as acceptor IEA


Pathways (from Reactome)
Pathway description
Regulation of Glucokinase by Glucokinase Regulatory Protein
Glycolysis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0009102 pancreatic B cell pancreatic B cell decreased amount , abnormal
pancreatic B cell decreased area , abnormal
pancreatic B cell regeneration decreased rate , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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