| MP:0000180 | abnormal circulating cholesterol level | "anomalous concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Igf1tm1Dlr/Igf1tm1Dlr,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA
|
| MP:0000189 | hypoglycemia | "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Gcktm2Mgn/Gck+
Genetic Background: B6.129S6-Gcktm2Mgn
Allelic Composition: Gcktm3Mgn/Gck+
Genetic Background: 129S6/SvEvTac-Gcktm3Mgn
Allelic Composition: Gcktm3Mgn/Gcktm3Mgn
Genetic Background: 129S6/SvEvTac-Gcktm3Mgn
|
| MP:0001260 | increased body weight | "greater than normal average weight " [J:33400] |
Show
Allelic Composition: Bdnftm1Jae/Bdnftm1Jae
Genetic Background: B6.129S4-Bdnftm1Jae
|
| MP:0001262 | decreased body weight | "lower than normal average weight " [J:61295] |
Show
Allelic Composition: GckRgsc210/Gck+
Genetic Background: involves: C57BL/6J * DBA/2J
Allelic Composition: GckRgsc392/GckRgsc392
Genetic Background: involves: C57BL/6J * DBA/2J
Allelic Composition: GckRgsc702/GckRgsc702
Genetic Background: involves: C57BL/6J * DBA/2J
Allelic Composition: Gcktm1Tka/Gck+,Irs1tm1Tka/Irs1tm1Tka
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA * ICR
Allelic Composition: GckGls006/GckGls006
Genetic Background: C3HeB/FeJ-GckGls006
Allelic Composition: Gckm1Rge/Gckm1Rge
Genetic Background: involves: C3HeB/FeJ
|
| MP:0001552 | increased circulating triglyceride level | "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416] |
Show
Allelic Composition: Igf1tm1Dlr/Igf1tm1Dlr,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA
|
| MP:0001554 | increased circulating free fatty acid level | "higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146] |
Show
Allelic Composition: Gcktm1.2Mgn/Gcktm1.2Mgn
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
|
| MP:0001559 | hyperglycemia | "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Igf1tm1Dlr/Igf1tm1Dlr,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA
Allelic Composition: Gcktm1Efr/Gck+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Gcktm1Tka/Gcktm1Tka
Genetic Background: involves: 129X1/SvJ * ICR
Allelic Composition: GckHlb62/?
Genetic Background: C57BL/6J-GckHlb62/J
Allelic Composition: GckRgsc210/Gck+
Genetic Background: involves: C57BL/6J * DBA/2J
Allelic Composition: GckRgsc210/GckRgsc210
Genetic Background: involves: C57BL/6J * DBA/2J
Allelic Composition: GckRgsc272/Gck+
Genetic Background: involves: C57BL/6J * DBA/2J
Allelic Composition: GckRgsc341/Gck+
Genetic Background: involves: C57BL/6J * DBA/2J
Allelic Composition: GckRgsc392/Gck+
Genetic Background: involves: C57BL/6J * DBA/2J
Allelic Composition: GckRgsc392/GckRgsc392
Genetic Background: involves: C57BL/6J * DBA/2J
Allelic Composition: GckRgsc475/Gck+
Genetic Background: involves: C57BL/6J * DBA/2J
Allelic Composition: GckRgsc702/Gck+
Genetic Background: involves: C57BL/6J * DBA/2J
Allelic Composition: GckRgsc702/GckRgsc702
Genetic Background: involves: C57BL/6J * DBA/2J
Allelic Composition: GckGena348/Gck+
Genetic Background: involves: BALB/c * C3H/He
Allelic Composition: GckGena348/GckGena348
Genetic Background: involves: BALB/c * C3H/He
Allelic Composition: Gcktm1Tka/Gck+
Genetic Background: involves: 129X1/SvJ * ICR
Allelic Composition: GckRgsc236/Gck+
Genetic Background: involves: C57BL/6J * DBA/2J
Allelic Composition: GckRgsc553/Gck+
Genetic Background: involves: C57BL/6J * DBA/2J
Allelic Composition: GckRgsc735/Gck+
Genetic Background: involves: C57BL/6J * DBA/2J
Allelic Composition: GckRgsc552/Gck+
Genetic Background: involves: C57BL/6J * DBA/2J
Allelic Composition: GckRgsc149/Gck+
Genetic Background: involves: C57BL/6J * DBA/2J
Allelic Composition: Gcktm1.2Mgn/Gcktm1.2Mgn
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
Allelic Composition: Gcktm1.2Mgn/Gck+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
Allelic Composition: Gcktm1.1Mgn/Gcktm1.1Mgn,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
Allelic Composition: Gcktm1.1Mgn/Gck+,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
Allelic Composition: Gcktm2Mgn/Gck+
Genetic Background: 129S6/SvEvTac-Gcktm2Mgn
Allelic Composition: Gcktm2Mgn/Gck+
Genetic Background: B6.129S6-Gcktm2Mgn
Allelic Composition: Gcktm2Mgn/Gcktm2Mgn
Genetic Background: 129S6/SvEvTac-Gcktm2Mgn
Allelic Composition: GckRgsc149/Gck+
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl
Allelic Composition: GckRgsc960/Gck+
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl
Allelic Composition: GckGls006/GckGls006
Genetic Background: C3HeB/FeJ-GckGls006
Allelic Composition: Gckm1Rge/Gck+
Genetic Background: involves: C3HeB/FeJ
Allelic Composition: Gckm1Rge/Gckm1Rge
Genetic Background: involves: C3HeB/FeJ
Allelic Composition: GckGls006/Gck+
Genetic Background: C3HeB/FeJ-GckGls006
Allelic Composition: GckSgrd/Gck+
Genetic Background: C57BL/6J-GckSgrd
Allelic Composition: GckSgrd/GckSgrd
Genetic Background: C57BL/6J-GckSgrd
Allelic Composition: GckSgrd-2Nwu/Gck+
Genetic Background: C57BL/6J-GckSgrd-2Nwu
Allelic Composition: GckSgrd-2Nwu/GckSgrd-2Nwu
Genetic Background: C57BL/6J-GckSgrd-2Nwu
Allelic Composition: GckSgrd/GckSgrd-2Nwu
Genetic Background: C57BL/6J-GckSgrd/GckSgrd-2Nwu
|
| MP:0001560 | abnormal circulating insulin level | "anomalous blood concentration of this polypeptide hormone, secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Gcktm3Mgn/Gcktm3Mgn
Genetic Background: 129S6/SvEvTac-Gcktm3Mgn
|
| MP:0001732 | postnatal growth retardation | "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
Allelic Composition: Gcktm1Tka/Gck+,Irs1tm1Tka/Irs1tm1Tka
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA * ICR
Allelic Composition: Gckm1Rge/Gckm1Rge
Genetic Background: involves: C3HeB/FeJ
|
| MP:0001759 | increased urine glucose level | "a greater level of excretion of glucose in the urine compared to the normal state" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Gcktm1Tka/Gcktm1Tka
Genetic Background: involves: 129X1/SvJ * ICR
Allelic Composition: GckRgsc210/GckRgsc210
Genetic Background: involves: C57BL/6J * DBA/2J
Allelic Composition: GckRgsc702/GckRgsc702
Genetic Background: involves: C57BL/6J * DBA/2J
Allelic Composition: Gcktm1Tka/Gck+
Genetic Background: involves: 129X1/SvJ * ICR
Allelic Composition: Gckm1Rge/Gckm1Rge
Genetic Background: involves: C3HeB/FeJ
|
| MP:0002078 | abnormal glucose homeostasis | "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Igf1tm1Dlr/Igf1tm1Dlr,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA
Allelic Composition: Gcktm1.1Mgn/Gcktm1.1Mgn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
Allelic Composition: Gcktm2Mgn/Gck+
Genetic Background: 129S6/SvEvTac-Gcktm2Mgn
Allelic Composition: Gcktm3Mgn/Gck+
Genetic Background: 129S6/SvEvTac-Gcktm3Mgn
Allelic Composition: Gcktm3Mgn/Gcktm3Mgn
Genetic Background: 129S6/SvEvTac-Gcktm3Mgn
|
| MP:0002079 | increased circulating insulin level | "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Gcktm1Tka/Gck+,Irs1tm1Tka/Irs1tm1Tka
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA * ICR
Allelic Composition: Gcktm1.1Mgn/Gcktm1.1Mgn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
Allelic Composition: Gckm1Rge/Gck+
Genetic Background: involves: C3HeB/FeJ
|
| MP:0002082 | postnatal lethality | "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: GckRgsc210/Gck+
Genetic Background: involves: C57BL/6J * DBA/2J
Allelic Composition: GckRgsc702/GckRgsc702
Genetic Background: involves: C57BL/6J * DBA/2J
Allelic Composition: Gckm1Rge/Gckm1Rge
Genetic Background: involves: C3HeB/FeJ
|
| MP:0002575 | increased circulating ketone body level | "greater than the normal amount of acetoacetate, 3-hydroxybutyrate and acteone in the blood; produced by fatty acid and carbohydrate metabolism and seen in conditions such as starvation and diabetes mellitus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator, J:71968] |
Show
Allelic Composition: Gcktm1Tka/Gcktm1Tka
Genetic Background: involves: 129X1/SvJ * ICR
|
| MP:0002628 | fatty liver | "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Igf1tm1Dlr/Igf1tm1Dlr,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA
Allelic Composition: Gcktm1Tka/Gcktm1Tka
Genetic Background: involves: 129X1/SvJ * ICR
Allelic Composition: GckRgsc210/GckRgsc210
Genetic Background: involves: C57BL/6J * DBA/2J
Allelic Composition: GckRgsc392/GckRgsc392
Genetic Background: involves: C57BL/6J * DBA/2J
Allelic Composition: GckRgsc702/GckRgsc702
Genetic Background: involves: C57BL/6J * DBA/2J
Allelic Composition: Gcktm1.2Mgn/Gcktm1.2Mgn
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
Allelic Composition: Gcktm1.2Mgn/Gck+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
Allelic Composition: Gcktm1.1Mgn/Gcktm1.1Mgn,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
|
| MP:0002727 | decreased circulating insulin level | "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Gcktm1Tka/Gcktm1Tka
Genetic Background: involves: 129X1/SvJ * ICR
Allelic Composition: GckRgsc272/Gck+
Genetic Background: involves: C57BL/6J * DBA/2J
Allelic Composition: GckRgsc392/Gck+
Genetic Background: involves: C57BL/6J * DBA/2J
Allelic Composition: GckRgsc475/Gck+
Genetic Background: involves: C57BL/6J * DBA/2J
Allelic Composition: GckRgsc702/Gck+
Genetic Background: involves: C57BL/6J * DBA/2J
Allelic Composition: Gcktm1.2Mgn/Gcktm1.2Mgn
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
Allelic Composition: Gcktm1.1Mgn/Gcktm1.1Mgn,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
Allelic Composition: GckGls006/Gck+
Genetic Background: C3HeB/FeJ-GckGls006
Allelic Composition: GckSgrd/Gck+
Genetic Background: C57BL/6J-GckSgrd
Allelic Composition: GckSgrd/GckSgrd
Genetic Background: C57BL/6J-GckSgrd
Allelic Composition: GckSgrd-2Nwu/GckSgrd-2Nwu
Genetic Background: C57BL/6J-GckSgrd-2Nwu
Allelic Composition: GckSgrd/GckSgrd-2Nwu
Genetic Background: C57BL/6J-GckSgrd/GckSgrd-2Nwu
|
| MP:0003059 | decreased insulin secretion | "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission] |
Show
Allelic Composition: Gcktm1Tka/Gcktm1Tka
Genetic Background: involves: 129X1/SvJ * ICR
Allelic Composition: Gcktm1Tka/Gck+
Genetic Background: involves: 129X1/SvJ * ICR
Allelic Composition: Gcktm1.2Mgn/Gck+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
Allelic Composition: Gcktm1.1Mgn/Gck+,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
Allelic Composition: Gcktm1.1Mgn/Gcktm1.1Mgn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
Allelic Composition: Gckm1Rge/Gck+
Genetic Background: involves: C3HeB/FeJ
Allelic Composition: GckGls006/Gck+
Genetic Background: C3HeB/FeJ-GckGls006
|
| MP:0003562 | abnormal beta cell physiology | "anomaly in the function of the insulin-producing cells of the islets of Langerhans in the pancreas" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Gcktm1Tka/Gcktm1Tka
Genetic Background: involves: 129X1/SvJ * ICR
|
| MP:0003564 | abnormal insulin secretion | "aberrant release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, smb:Susan M Bello, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Gcktm2Mgn/Gck+
Genetic Background: 129S6/SvEvTac-Gcktm2Mgn
Allelic Composition: Gcktm3Mgn/Gck+
Genetic Background: 129S6/SvEvTac-Gcktm3Mgn
Allelic Composition: Gcktm3Mgn/Gcktm3Mgn
Genetic Background: 129S6/SvEvTac-Gcktm3Mgn
|
| MP:0005215 | abnormal islet of Langerhans morphology | "anomalous morphology of these structures that are scattered throughout the pancreas and comprise its endocrine portion; within each islet there are three cell types: alpha, beta, and delta " [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: GckGls006/GckGls006
Genetic Background: C3HeB/FeJ-GckGls006
|
| MP:0005217 | abnormal pancreatic beta cell morphology | "malformation of the cells of the pancreas that secrete insulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: GckGls006/GckGls006
Genetic Background: C3HeB/FeJ-GckGls006
|
| MP:0005293 | impaired glucose tolerance | "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Igf1tm1Dlr/Igf1tm1Dlr,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA
Allelic Composition: Gcktm1Efr/Gck+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: GckHlb62/?
Genetic Background: C57BL/6J-GckHlb62/J
Allelic Composition: GckRgsc210/Gck+
Genetic Background: involves: C57BL/6J * DBA/2J
Allelic Composition: GckRgsc272/Gck+
Genetic Background: involves: C57BL/6J * DBA/2J
Allelic Composition: GckRgsc341/Gck+
Genetic Background: involves: C57BL/6J * DBA/2J
Allelic Composition: GckRgsc392/Gck+
Genetic Background: involves: C57BL/6J * DBA/2J
Allelic Composition: GckRgsc475/Gck+
Genetic Background: involves: C57BL/6J * DBA/2J
Allelic Composition: GckRgsc702/Gck+
Genetic Background: involves: C57BL/6J * DBA/2J
Allelic Composition: GckGena348/Gck+
Genetic Background: involves: BALB/c * C3H/He
Allelic Composition: GckGena348/GckGena348
Genetic Background: involves: BALB/c * C3H/He
Allelic Composition: Gcktm1Tka/Gck+
Genetic Background: involves: 129X1/SvJ * ICR
Allelic Composition: Gcktm1Tka/Gck+,Irs1tm1Tka/Irs1tm1Tka
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA * ICR
Allelic Composition: Gcktm1.2Mgn/Gck+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
Allelic Composition: Gcktm1.1Mgn/Gck+,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
Allelic Composition: Gcktm1.1Mgn/Gcktm1.1Mgn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
Allelic Composition: Gcktm1Hrt/Gck+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA
Allelic Composition: Gcktm2Mgn/Gck+
Genetic Background: 129S6/SvEvTac-Gcktm2Mgn
Allelic Composition: Gckm1Rge/Gck+
Genetic Background: involves: C3HeB/FeJ
Allelic Composition: GckGls006/Gck+
Genetic Background: C3HeB/FeJ-GckGls006
Allelic Composition: GckM1Btlr/GckM1Btlr
Genetic Background: C57BL/6J-GckM1Btlr
Allelic Composition: GckM1Btlr/Gck+
Genetic Background: C57BL/6J-GckM1Btlr
|
| MP:0005331 | insulin resistance | "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Gcktm1Tka/Gck+,Irs1tm1Tka/Irs1tm1Tka
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA * ICR
Allelic Composition: Gcktm1.1Mgn/Gcktm1.1Mgn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
Allelic Composition: Gckm1Rge/Gck+
Genetic Background: involves: C3HeB/FeJ
|
| MP:0005439 | decreased glycogen level | "less than the normal concentration of this readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Igf1tm1Dlr/Igf1tm1Dlr,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA
Allelic Composition: GckRgsc210/GckRgsc210
Genetic Background: involves: C57BL/6J * DBA/2J
Allelic Composition: GckRgsc392/GckRgsc392
Genetic Background: involves: C57BL/6J * DBA/2J
Allelic Composition: GckRgsc702/GckRgsc702
Genetic Background: involves: C57BL/6J * DBA/2J
Allelic Composition: Gcktm1.2Mgn/Gcktm1.2Mgn
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
Allelic Composition: Gcktm1.2Mgn/Gck+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
Allelic Composition: Gcktm1.1Mgn/Gcktm1.1Mgn,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
Allelic Composition: Gcktm1.1Mgn/Gck+,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
Allelic Composition: Gcktm1.1Mgn/Gcktm1.1Mgn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
|
| MP:0005491 | islet cell hyperplasia | "increased numbers cells within the structures that are scattered throughout the pancreas and comprise its endocrine portion" [J:48446, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Gcktm1Tka/Gck+,Irs1tm1Tka/Irs1tm1Tka
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA * ICR
|
| MP:0005559 | increased circulating glucose level | "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission] |
Show
Allelic Composition: Plxna3tm1Matl/Plxna3tm1Matl,Plxna4tm1Matl/Plxna4tm1Matl
Genetic Background: either: (involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6) or (involves: 129P2/OlaHsd * 129S1/Sv * CD-1)
Allelic Composition: Gcktm1.1Mgn/Gcktm1.1Mgn
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
Allelic Composition: Gcktm1.1Mgn/Gcktm1.1Mgn
Genetic Background: 129S6/SvEvTac-Gcktm1.1Mgn
Allelic Composition: Gcktm1.1Mgn/Gcktm1.1Mgn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
Allelic Composition: Gcktm1Hrt/Gck+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA
Allelic Composition: GckGls006/GckGls006
Genetic Background: C3HeB/FeJ-GckGls006
Allelic Composition: GckGls006/Gck+
Genetic Background: C3HeB/FeJ-GckGls006
|
| MP:0005560 | decreased circulating glucose level | "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Gcktm3Mgn/Gcktm3Mgn
Genetic Background: 129S6/SvEvTac-Gcktm3Mgn
|
| MP:0006353 | incleased glycosylated hemoglobin level | "greater than normal blood concentration of a modified form of hemoglobin with an attached saccharide molecule " [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator", Riken ENU:Hiroshi Masuya] |
Show
Allelic Composition: GckRgsc210/Gck+
Genetic Background: involves: C57BL/6J * DBA/2J
Allelic Composition: GckRgsc272/Gck+
Genetic Background: involves: C57BL/6J * DBA/2J
Allelic Composition: GckRgsc341/Gck+
Genetic Background: involves: C57BL/6J * DBA/2J
Allelic Composition: GckRgsc392/Gck+
Genetic Background: involves: C57BL/6J * DBA/2J
Allelic Composition: GckRgsc475/Gck+
Genetic Background: involves: C57BL/6J * DBA/2J
Allelic Composition: GckRgsc702/Gck+
Genetic Background: involves: C57BL/6J * DBA/2J
Allelic Composition: GckRgsc236/Gck+
Genetic Background: involves: C57BL/6J * DBA/2J
Allelic Composition: GckRgsc553/Gck+
Genetic Background: involves: C57BL/6J * DBA/2J
Allelic Composition: GckRgsc735/Gck+
Genetic Background: involves: C57BL/6J * DBA/2J
Allelic Composition: GckRgsc552/Gck+
Genetic Background: involves: C57BL/6J * DBA/2J
Allelic Composition: GckRgsc149/Gck+
Genetic Background: involves: C57BL/6J * DBA/2J
|
| MP:0009113 | increased pancreatic beta cell mass | "greater total physical bulk or volume of a pancreatic beta cell compared to the normal state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Gcktm1Tka/Gck+,Irs1tm1Tka/Irs1tm1Tka
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA * ICR
|
| MP:0009114 | decreased pancreatic beta cell mass | "reduced total physical bulk or volume of a pancreatic beta cell compared to the normal state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: GckGls006/GckGls006
Genetic Background: C3HeB/FeJ-GckGls006
Allelic Composition: Gckm1Rge/Gck+
Genetic Background: involves: C3HeB/FeJ
Allelic Composition: GckGls006/Gck+
Genetic Background: C3HeB/FeJ-GckGls006
|
| MP:0009172 | small pancreatic islets | "decrease in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414] |
Show
Allelic Composition: GckGls006/GckGls006
Genetic Background: C3HeB/FeJ-GckGls006
Allelic Composition: Gckm1Rge/Gck+
Genetic Background: involves: C3HeB/FeJ
Allelic Composition: GckGls006/Gck+
Genetic Background: C3HeB/FeJ-GckGls006
|
| MP:0011085 | complete postnatal lethality | "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
Show
Allelic Composition: Igf1tm1Dlr/Igf1tm1Dlr,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA
Allelic Composition: Gcktm1Tka/Gcktm1Tka
Genetic Background: involves: 129X1/SvJ * ICR
Allelic Composition: Gcktm1.2Mgn/Gcktm1.2Mgn
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
Allelic Composition: Gcktm2Mgn/Gcktm2Mgn
Genetic Background: 129S6/SvEvTac-Gcktm2Mgn
|
| MP:0011088 | partial neonatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith] |
Show
Allelic Composition: Gcktm1.1Mgn/Gcktm1.1Mgn,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
|
| MP:0011108 | partial embryonic lethality during organogenesis | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith] |
Show
Allelic Composition: Igf1tm1Dlr/Igf1tm1Dlr,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA
|
| MP:0011606 | decreased glucokinase activity | "reduced ability to catalyze the reaction: ATP + D-glucose = ADP + D-glucose-6-phosphate" [GO:0004340] |
Show
Allelic Composition: Gcktm2Mgn/Gck+
Genetic Background: 129S6/SvEvTac-Gcktm2Mgn
Allelic Composition: Gcktm3Mgn/Gck+
Genetic Background: 129S6/SvEvTac-Gcktm3Mgn
Allelic Composition: Gcktm3Mgn/Gcktm3Mgn
Genetic Background: 129S6/SvEvTac-Gcktm3Mgn
Allelic Composition: GckGls006/GckGls006
Genetic Background: C3HeB/FeJ-GckGls006
Allelic Composition: GckGls006/Gck+
Genetic Background: C3HeB/FeJ-GckGls006
|
