Manteia

ENSMUSG00000037012

Mus musculus

Features

Gene ID:	ENSMUSG00000037012

Biological name :	Hk1

Synonyms :	Hexokinase-1 / Hk1 / P17710

Possible biological names infered from orthology :	P19367

Species:	Mus musculus

Chr. number:	10
Strand:	-1
Band:	B4
Gene start:	62268855
Gene end:	62379908

Corresponding Affymetrix probe sets:	10369541 (MoGene1.0st) 1420901_a_at (Mouse Genome 430 2.0 Array) 1437974_a_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000121487 Ensembl peptide - ENSMUSP00000123375 Ensembl peptide - ENSMUSP00000122791 Ensembl peptide - ENSMUSP00000122717 Ensembl peptide - ENSMUSP00000122479 Ensembl peptide - ENSMUSP00000072195 Ensembl peptide - ENSMUSP00000097282 Ensembl peptide - ENSMUSP00000111946 Ensembl peptide - ENSMUSP00000114586 Ensembl peptide - ENSMUSP00000115218 Ensembl peptide - ENSMUSP00000115426 Ensembl peptide - ENSMUSP00000115990 Ensembl peptide - ENSMUSP00000117752 Ensembl peptide - ENSMUSP00000118166 Ensembl peptide - ENSMUSP00000118576 Ensembl peptide - ENSMUSP00000118601 Ensembl peptide - ENSMUSP00000119812 Ensembl peptide - ENSMUSP00000120151 NCBI entrez gene - 15275 See in Manteia. MGI - MGI:96103 RefSeq - XM_006513247 RefSeq - XM_006513246 RefSeq - XM_006513245 RefSeq - XM_006513244 RefSeq - XM_006513243 RefSeq - NM_001146100 RefSeq - XM_006513242 RefSeq - NM_010438 RefSeq Peptide - NP_001139572 RefSeq Peptide - NP_034568 swissprot - P17710 swissprot - Q6GQU1 swissprot - D3Z365 swissprot - G3UVV4 swissprot - F6QD41 swissprot - B4YB29 swissprot - D3YYR4 swissprot - D3Z105 Ensembl - ENSMUSG00000037012

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
hk1	ENSDARG00000039452	Danio rerio
HK1	ENSGALG00000004222	Gallus gallus
HK1	ENSG00000156515	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Hk2 / O08528 / Hexokinase-2 / P52789*	ENSMUSG00000000628	69
Hkdc1 / Q91W97 / Putative hexokinase HKDC1 / Q2TB90* / hexokinase domain containing 1*	ENSMUSG00000020080	67
Hk3 / Q3TRM8 / Hexokinase-3 / P52790*	ENSMUSG00000025877	50
Gck / P52792 / Glucokinase / P35557*	ENSMUSG00000041798	23

Protein motifs (from Interpro)

Interpro ID	Name
IPR001312	Hexokinase
IPR019807	Hexokinase, binding site
IPR022672	Hexokinase, N-terminal
IPR022673	Hexokinase, C-terminal

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001678	cellular glucose homeostasis	IBA
biological_process	GO:0002741	positive regulation of cytokine secretion involved in immune response	IDA
biological_process	GO:0005975	carbohydrate metabolic process	IEA
biological_process	GO:0006096	glycolytic process	TAS
biological_process	GO:0008152	metabolic process	IEA
biological_process	GO:0016310	phosphorylation	IEA
biological_process	GO:0019318	hexose metabolic process	IEA
biological_process	GO:0046835	carbohydrate phosphorylation	IMP
biological_process	GO:0050718	positive regulation of interleukin-1 beta secretion	IDA
biological_process	GO:0051156	glucose 6-phosphate metabolic process	IEA
biological_process	GO:0061621	canonical glycolysis	IC
biological_process	GO:0072655	establishment of protein localization to mitochondrion	ISO
biological_process	GO:0072656	maintenance of protein location in mitochondrion	ISO
cellular_component	GO:0005739	mitochondrion	ISO
cellular_component	GO:0005741	mitochondrial outer membrane	IEA
cellular_component	GO:0005829	cytosol	IDA
cellular_component	GO:0005929	cilium	IDA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0045121	membrane raft	IDA
cellular_component	GO:0097228	sperm principal piece	IDA
molecular_function	GO:0000166	nucleotide binding	IEA
molecular_function	GO:0003824	catalytic activity	IEA
molecular_function	GO:0004340	glucokinase activity	IDA
molecular_function	GO:0004396	hexokinase activity	IMP
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0005524	ATP binding	IEA
molecular_function	GO:0005536	glucose binding	IEA
molecular_function	GO:0008865	fructokinase activity	IBA
molecular_function	GO:0016301	kinase activity	IEA
molecular_function	GO:0016740	transferase activity	IEA
molecular_function	GO:0016773	phosphotransferase activity, alcohol group as acceptor	IEA
molecular_function	GO:0019158	mannokinase activity	IBA
molecular_function	GO:0042834	peptidoglycan binding	IDA

Pathways (from Reactome)

Pathway description

Glycolysis

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000208	decreased hematocrit	"less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Grid2^Lc/Grid2⁺ Genetic Background: B6CBACa A^w-J/A-Grid2^Lc/J
MP:0000245	abnormal erythropoiesis	"atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]	Show Allelic Composition: Grid2^Lc/Grid2⁺ Genetic Background: B6CBACa A^w-J/A-Grid2^Lc/J
MP:0000689	abnormal spleen morphology	"atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]	Show Allelic Composition: Grid2^Lc/Grid2⁺ Genetic Background: B6CBACa A^w-J/A-Grid2^Lc/J
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Grid2^Lc/Grid2⁺ Genetic Background: B6CBACa A^w-J/A-Grid2^Lc/J
MP:0001577	anemia	"less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]	Show Allelic Composition: Grid2^Lc/Grid2⁺ Genetic Background: B6CBACa A^w-J/A-Grid2^Lc/J
MP:0001585	hemolytic anemia	"an anemic condition resulting from an increased rate of erythrocyte destruction" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Grid2^Lc/Grid2⁺ Genetic Background: B6CBACa A^w-J/A-Grid2^Lc/J
MP:0001926	female infertility	"inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]	Show Allelic Composition: Grid2^Lc/Grid2⁺ Genetic Background: B6CBACa A^w-J/A-Grid2^Lc/J
MP:0002447	abnormal erythrocyte morphology	"structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Grid2^Lc/Grid2⁺ Genetic Background: B6CBACa A^w-J/A-Grid2^Lc/J
MP:0002590	increased mean corpuscular volume	"greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Grid2^Lc/Grid2⁺ Genetic Background: B6CBACa A^w-J/A-Grid2^Lc/J
MP:0002640	reticulocytosis	"an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]	Show Allelic Composition: Grid2^Lc/Grid2⁺ Genetic Background: B6CBACa A^w-J/A-Grid2^Lc/J
MP:0002642	anisocytosis	"blood cells of variable size on smear" [J:7209, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]	Show Allelic Composition: Grid2^Lc/Grid2⁺ Genetic Background: B6CBACa A^w-J/A-Grid2^Lc/J
MP:0002814	hyperchromasia	"increased capacity of a cell to stain with dye; usually refers to staining of cell nuclei with hematoxylin" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Grid2^Lc/Grid2⁺ Genetic Background: B6CBACa A^w-J/A-Grid2^Lc/J
MP:0002874	decreased hemoglobin content	"decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Grid2^Lc/Grid2⁺ Genetic Background: B6CBACa A^w-J/A-Grid2^Lc/J
MP:0002875	decreased erythrocyte count	"reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Grid2^Lc/Grid2⁺ Genetic Background: B6CBACa A^w-J/A-Grid2^Lc/J
MP:0003717	pallor	"an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Grid2^Lc/Grid2⁺ Genetic Background: B6CBACa A^w-J/A-Grid2^Lc/J
MP:0004952	increased spleen weight	"greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Grid2^Lc/Grid2⁺ Genetic Background: B6CBACa A^w-J/A-Grid2^Lc/J
MP:0005097	polychromatophilia	"condition characterized by the presence of red blood cells that have an affinity for acid, basic, and neutral stains" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:305]	Show Allelic Composition: Grid2^Lc/Grid2⁺ Genetic Background: B6CBACa A^w-J/A-Grid2^Lc/J
MP:0005344	increased circulating bilirubin level	"greater than the normal concentration in the blood of this yellow heme breakdown product" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]	Show Allelic Composition: Grid2^Lc/Grid2⁺ Genetic Background: B6CBACa A^w-J/A-Grid2^Lc/J
MP:0005562	decreased mean corpuscular hemoglobin	"less than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Grid2^Lc/Grid2⁺ Genetic Background: B6CBACa A^w-J/A-Grid2^Lc/J
MP:0008476	increased spleen red pulp amount	"increase in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Grid2^Lc/Grid2⁺ Genetic Background: B6CBACa A^w-J/A-Grid2^Lc/J
MP:0008807	increased liver iron level	"increase in the amount of iron present in the liver tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Grid2^Lc/Grid2⁺ Genetic Background: B6CBACa A^w-J/A-Grid2^Lc/J
MP:0010375	increased kidney iron level	"increase in the amount of iron present in the renal tissue" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Grid2^Lc/Grid2⁺ Genetic Background: B6CBACa A^w-J/A-Grid2^Lc/J

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr