ENSMUSG00000020080


Mus musculus

Features
Gene ID: ENSMUSG00000020080
  
Biological name :Hkdc1
  
Synonyms : Hkdc1 / Putative hexokinase HKDC1 / Q91W97
  
Possible biological names infered from orthology : hexokinase domain containing 1 / Q2TB90
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: B4
Gene start: 62383137
Gene end: 62422491
  
Corresponding Affymetrix probe sets: 10369567 (MoGene1.0st)   1425900_at (Mouse Genome 430 2.0 Array)   1459421_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020277
NCBI entrez gene - 216019     See in Manteia.
MGI - MGI:2384910
RefSeq - XM_011243398
RefSeq - NM_145419
RefSeq - XM_006513473
RefSeq - XM_011243397
RefSeq Peptide - NP_663394
swissprot - Q91W97
Ensembl - ENSMUSG00000020080
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hkdc1ENSDARG00000038703Danio rerio
 HKDC1ENSGALG00000021039Gallus gallus
 HKDC1ENSG00000156510Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hk1 / P17710 / Hexokinase-1 / P19367*ENSMUSG0000003701270
Hk2 / O08528 / Hexokinase-2 / P52789*ENSMUSG0000000062868
Hk3 / Q3TRM8 / Hexokinase-3 / P52790*ENSMUSG0000002587752
Gck / P52792 / Glucokinase / P35557*ENSMUSG0000004179824


Protein motifs (from Interpro)
Interpro ID Name
 IPR001312  Hexokinase
 IPR019807  Hexokinase, binding site
 IPR022672  Hexokinase, N-terminal
 IPR022673  Hexokinase, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001678 cellular glucose homeostasis IBA
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0006096 glycolytic process IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0019318 hexose metabolic process IEA
 biological_processGO:0046835 carbohydrate phosphorylation IEA
 biological_processGO:0051156 glucose 6-phosphate metabolic process IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004340 glucokinase activity IBA
 molecular_functionGO:0004396 hexokinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0005536 glucose binding IEA
 molecular_functionGO:0008865 fructokinase activity IBA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016773 phosphotransferase activity, alcohol group as acceptor IEA
 molecular_functionGO:0019158 mannokinase activity IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Smarcd1tm1.1Jddl/Smarcd1tm1.1Jddl,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0009355 increased liver triglyceride level "higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Smarcd1tm1.1Jddl/Smarcd1tm1.1Jddl,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Smarcd1tm1.1Jddl/Smarcd1tm1.1Jddl,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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