ENSMUSG00000059434


Mus musculus

Features
Gene ID: ENSMUSG00000059434
  
Biological name :Gckr
  
Synonyms : Gckr / Glucokinase regulatory protein / Q91X44
  
Possible biological names infered from orthology : glucokinase regulator / Q14397
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: B1
Gene start: 31297443
Gene end: 31327314
  
Corresponding Affymetrix probe sets: 10520763 (MoGene1.0st)   1426059_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000144202
Ensembl peptide - ENSMUSP00000144568
Ensembl peptide - ENSMUSP00000072084
NCBI entrez gene - 231103     See in Manteia.
MGI - MGI:1096345
RefSeq - XM_006503881
RefSeq - XM_006503882
RefSeq - XM_006503883
RefSeq - NM_144909
RefSeq Peptide - NP_659158
swissprot - Q91X44
swissprot - A0A0J9YUI8
swissprot - A0A0J9YVA3
Ensembl - ENSMUSG00000059434
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gckrENSDARG00000086620Danio rerio
 GCKRENSG00000084734Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001347  Sugar isomerase (SIS)
 IPR005486  Glucokinase regulatory protein, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000060 protein import into nucleus, translocation IEA
 biological_processGO:0001678 cellular glucose homeostasis IMP
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0009750 response to fructose IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0033132 negative regulation of glucokinase activity IEA
 biological_processGO:0033133 positive regulation of glucokinase activity IMP
 biological_processGO:0034504 protein localization to nucleus IMP
 biological_processGO:0046415 urate metabolic process ISO
 biological_processGO:0070328 triglyceride homeostasis ISO
 biological_processGO:1901135 carbohydrate derivative metabolic process IEA
 biological_processGO:1903300 negative regulation of hexokinase activity IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0004857 enzyme inhibitor activity IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0030246 carbohydrate binding IEA
 molecular_functionGO:0070095 fructose-6-phosphate binding ISS
 molecular_functionGO:0097367 carbohydrate derivative binding IEA


Pathways (from Reactome)
Pathway description
Regulation of Glucokinase by Glucokinase Regulatory Protein


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Reltm1Hcl/Reltm1Hcl
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Gckrtm1Bms/Gckrtm1Bms
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gckrtm1Bms/Gckrtm1Bms
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Atrnmg/Atrnmg
Genetic Background: C3H/HeJ.Cg-Atrnmg

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Reltm1Hcl/Reltm1Hcl
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Gckrtm1Jfg/Gckrtm1Jfg
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0005319 abnormal enzyme/ coenzyme level "altered concentration of any of these proteins, or their cofactors, that act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Reltm1Hcl/Reltm1Hcl
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Gckrtm1Jfg/Gckrtm1Jfg
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gckrtm1Bms/Gckrtm1Bms
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005439 decreased glycogen level "less than the normal concentration of this readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Reltm1Hcl/Reltm1Hcl
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Gckrtm1Bms/Gckrtm1Bms
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0011606 decreased glucokinase activity "reduced ability to catalyze the reaction: ATP + D-glucose = ADP + D-glucose-6-phosphate" [GO:0004340]
Show

Allelic Composition: Reltm1Hcl/Reltm1Hcl
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Gckrtm1Jfg/Gckrtm1Jfg
Genetic Background: involves: 129S/SvEv * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000041798 Gck / P52792 / Glucokinase / P35557*  / complex / reaction






 

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