ENSG00000084734


Homo sapiens

Features
Gene ID: ENSG00000084734
  
Biological name :GCKR
  
Synonyms : GCKR / glucokinase regulator / Q14397
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: p23.3
Gene start: 27496842
Gene end: 27523684
  
Corresponding Affymetrix probe sets: 206867_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000416917
Ensembl peptide - ENSP00000264717
Ensembl peptide - ENSP00000398303
Ensembl peptide - ENSP00000399463
NCBI entrez gene - 2646     See in Manteia.
OMIM - 600842
RefSeq - XM_017003797
RefSeq - NM_001486
RefSeq - XM_011532763
RefSeq - XM_017003796
RefSeq Peptide - NP_001477
swissprot - Q14397
swissprot - H7C1B4
swissprot - H7C4D3
swissprot - A0A0C4DFN2
Ensembl - ENSG00000084734
  
Related genetic diseases (OMIM): 613463 - [Fasting plasma glucose level QTL 5], 613463
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gckrENSDARG00000086620Danio rerio
 GckrENSMUSG00000059434Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001347  Sugar isomerase (SIS)
 IPR005486  Glucokinase regulatory protein, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000060 protein import into nucleus, translocation ISS
 biological_processGO:0001678 cellular glucose homeostasis IEA
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0006110 regulation of glycolytic process TAS
 biological_processGO:0009750 response to fructose IDA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0033132 negative regulation of glucokinase activity IDA
 biological_processGO:0033133 positive regulation of glucokinase activity IEA
 biological_processGO:0034504 protein localization to nucleus IEA
 biological_processGO:0046415 urate metabolic process IMP
 biological_processGO:0070328 triglyceride homeostasis IMP
 biological_processGO:1901135 carbohydrate derivative metabolic process IEA
 biological_processGO:1903300 negative regulation of hexokinase activity IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0004857 enzyme inhibitor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0030246 carbohydrate binding IEA
 molecular_functionGO:0070095 fructose-6-phosphate binding IDA
 molecular_functionGO:0097367 carbohydrate derivative binding IEA


Pathways (from Reactome)
Pathway description
Regulation of Glucokinase by Glucokinase Regulatory Protein
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000106633 GCK / P35557 / glucokinase  / reaction / complex






 

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