ENSDARG00000068567


Danio rerio

Features
Gene ID: ENSDARG00000068567
  
Biological name :shha
  
Synonyms : Q92008 / shha / sonic hedgehog a
  
Possible biological names infered from orthology :
  
Species: Danio rerio
  
Chr. number: 7
Strand: 1
Band:
Gene start: 40884012
Gene end: 40893295
  
Corresponding Affymetrix probe sets: Dr.36.1.S2_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000125090
NCBI entrez gene - 30269     See in Manteia.
swissprot - Q1MTB5
swissprot - Q92008
ZFIN ID - ZDB-GENE-980526-166
Ensembl - ENSDARG00000068567
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
No match


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
shhb / Q90419 / sonic hedgehog bENSDARG0000003886770
ihha / Indian hedgehog homolog a / IHH* / Q14623* / P97812* / indian hedgehog*ENSDARG0000005873360
ihhb / Indian hedgehog homolog b / IHH* / Q14623* / P97812* / indian hedgehog*ENSDARG0000005881557
dhh / desert hedgehog / O43323* / Q61488* / Desert hedgehog protein Desert hedgehog protein N-product Desert hedgehog protein C-product*ENSDARG0000003706246


Protein motifs (from Interpro)
Interpro ID Name
 IPR000320  Hedgehog, N-terminal signalling domain
 IPR001657  Hedgehog protein
 IPR001767  Hedgehog protein, Hint domain
 IPR003586  Hint domain C-terminal
 IPR003587  Hint domain N-terminal
 IPR006141  Intein N-terminal splicing region
 IPR009045  Hedgehog signalling/DD-peptidase zinc-binding domain superfamily
 IPR028992  Hedgehog/Intein (Hint) domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001708 cell fate specification IMP
 biological_processGO:0001756 somitogenesis IMP
 biological_processGO:0001839 neural plate morphogenesis IMP
 biological_processGO:0001947 heart looping IDA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007224 smoothened signaling pathway IGI
 biological_processGO:0007267 cell-cell signaling IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007368 determination of left/right symmetry IDA
 biological_processGO:0007399 nervous system development IMP
 biological_processGO:0007411 axon guidance IMP
 biological_processGO:0007417 central nervous system development IMP
 biological_processGO:0007420 brain development IMP
 biological_processGO:0007507 heart development IMP
 biological_processGO:0007517 muscle organ development IMP
 biological_processGO:0008015 blood circulation IMP
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0009952 anterior/posterior pattern specification IMP
 biological_processGO:0009953 dorsal/ventral pattern formation IMP
 biological_processGO:0010001 glial cell differentiation IMP
 biological_processGO:0010002 cardioblast differentiation IMP
 biological_processGO:0010468 regulation of gene expression IDA
 biological_processGO:0016539 intein-mediated protein splicing IEA
 biological_processGO:0021508 floor plate formation IMP
 biological_processGO:0021520 spinal cord motor neuron cell fate specification IMP
 biological_processGO:0021536 diencephalon development IGI
 biological_processGO:0021984 adenohypophysis development IMP
 biological_processGO:0030182 neuron differentiation IMP
 biological_processGO:0030900 forebrain development IMP
 biological_processGO:0030902 hindbrain development IMP
 biological_processGO:0030917 midbrain-hindbrain boundary development IMP
 biological_processGO:0030947 regulation of vascular endothelial growth factor receptor signaling pathway IMP
 biological_processGO:0031016 pancreas development IMP
 biological_processGO:0031018 endocrine pancreas development IMP
 biological_processGO:0031076 embryonic camera-type eye development IMP
 biological_processGO:0032835 glomerulus development IMP
 biological_processGO:0033339 pectoral fin development IMP
 biological_processGO:0033504 floor plate development IMP
 biological_processGO:0035143 caudal fin morphogenesis IMP
 biological_processGO:0042063 gliogenesis IMP
 biological_processGO:0042462 eye photoreceptor cell development IMP
 biological_processGO:0042476 odontogenesis IMP
 biological_processGO:0042694 muscle cell fate specification IMP
 biological_processGO:0043010 camera-type eye development IDA
 biological_processGO:0045494 photoreceptor cell maintenance IMP
 biological_processGO:0048557 embryonic digestive tract morphogenesis IMP
 biological_processGO:0048618 post-embryonic foregut morphogenesis IMP
 biological_processGO:0048663 neuron fate commitment IGI
 biological_processGO:0048702 embryonic neurocranium morphogenesis IMP
 biological_processGO:0048703 embryonic viscerocranium morphogenesis IMP
 biological_processGO:0048709 oligodendrocyte differentiation IMP
 biological_processGO:0048741 skeletal muscle fiber development IGI
 biological_processGO:0048793 pronephros development IMP
 biological_processGO:0048795 swim bladder morphogenesis IMP
 biological_processGO:0048839 inner ear development IGI
 biological_processGO:0055002 striated muscle cell development IMP
 biological_processGO:0060956 endocardial cell differentiation IGI
 biological_processGO:0061035 regulation of cartilage development IGI
 biological_processGO:0070444 oligodendrocyte progenitor proliferation IMP
 biological_processGO:1905178 regulation of cardiac muscle tissue regeneration IMP
 biological_processGO:2000223 regulation of BMP signaling pathway involved in heart jogging IDA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000003 adaxial cell adaxial cell physical object quality , abnormal
adaxial cell immature , abnormal
adaxial cell decreased amount , abnormal
adaxial cell absent , abnormal
Show

 ZFA:0000008 brain brain necrotic , abnormal
Show

 ZFA:0000022 floor plate floor plate morphology , abnormal
floor plate quality , abnormal
floor plate hypoplastic , abnormal
Show

 ZFA:0000029 hindbrain hindbrain decreased amount , abnormal
Show

 ZFA:0000037 anatomical structure anatomical structure absent , abnormal
anatomical structure decreased amount , abnormal
Show

 ZFA:0000042 midbrain hindbrain boundary midbrain hindbrain boundary absent , abnormal
midbrain hindbrain boundary present , ameliorated
midbrain hindbrain boundary morphology , abnormal
Show

 ZFA:0000066 proctodeum proctodeum malformed , abnormal
proctodeum atretic , abnormal
Show

 ZFA:0000075 spinal cord spinal cord morphology , abnormal
Show

 ZFA:0000076 swim bladder swim bladder hypoplastic , abnormal
swim bladder mesenchyme decreased size , abnormal
swim bladder mesenchyme disorganized , abnormal
swim bladder epithelium decreased size , abnormal
swim bladder smooth muscle absent , abnormal
swim bladder mesothelial cell disorganized , abnormal
swim bladder decreased size , abnormal
swim bladder physical object quality , abnormal
Show

 ZFA:0000085 apical ectodermal ridge pectoral fin bud apical ectodermal ridge pectoral fin bud absent , abnormal
Show

 ZFA:0000101 diencephalon diencephalon dopaminergic neuron decreased amount , abnormal
Show

 ZFA:0000107 eye eye decreased size , abnormal
eye decreased amount , abnormal
Show

 ZFA:0000108 fin fin decreased size , abnormal
Show

 ZFA:0000109 forebrain forebrain decreased amount , abnormal
Show

 ZFA:0000114 heart heart quality , abnormal
heart absent , abnormal
heart edematous , abnormal
heart decreased amount , abnormal
Show

 ZFA:0000123 liver liver increased size , abnormal
Show

 ZFA:0000135 notochord notochord quality , abnormal
notochord morphology , abnormal
Show

 ZFA:0000140 pancreas pancreas morphology , abnormal
Show

 ZFA:0000141 pectoral fin bud pectoral fin bud morphology , abnormal
pectoral fin bud decreased size , abnormal
pectoral fin bud cell proliferation decreased frequency , abnormal
pectoral fin bud portion of tissue poorly differentiated , abnormal
Show

 ZFA:0000155 somite somite U-shaped , abnormal
somite morphology , abnormal
somite shape , abnormal
somite has extra parts of type muscle precursor cell , abnormal
somite quality , abnormal
somite decreased size , abnormal
somite muscle pioneer decreased amount , abnormal
Show

 ZFA:0000184 cleithrum cleithrum decreased size , abnormal
Show

 ZFA:0000204 esophagus esophagus malformed , abnormal
Show

 ZFA:0000254 pancreas primordium pancreas primordium hypoplastic , abnormal
Show

 ZFA:0000279 segmental plate segmental plate anterior region has fewer parts of type adaxial cell , abnormal
Show

 ZFA:0000282 sensory system sensory system quality , abnormal
Show

 ZFA:0000292 surface structure surface structure quality , abnormal
Show

 ZFA:0000396 nervous system nervous system quality , abnormal
Show

 ZFA:0000407 pectoral girdle pectoral girdle absent , abnormal
pectoral girdle morphology , abnormal
Show

 ZFA:0000539 locus coeruleus locus coeruleus neuron decreased amount , abnormal
Show

 ZFA:0000671 horizontal myoseptum horizontal myoseptum hypoplastic , abnormal
horizontal myoseptum absent , abnormal
Show

 ZFA:0000943 pectoral fin skeleton pectoral fin skeleton cell decreased amount , abnormal
Show

 ZFA:0001058 caudal fin caudal fin melanocyte mislocalised , abnormal
Show

 ZFA:0001086 muscle pioneer muscle pioneer absent , abnormal
Show

 ZFA:0001089 myoseptum myoseptum quality , abnormal
myoseptum aplastic , abnormal
Show

 ZFA:0001094 whole organism whole organism apoptotic , abnormal
whole organism lacks all parts of type ceratobranchial 5 tooth , abnormal
whole organism lethal (sensu genetics) , abnormal
whole organism viability , abnormal
whole organism movement behavioral quality , abnormal
whole organism decreased behavioural activity , abnormal
whole organism shape , abnormal
Show

 ZFA:0001115 trunk trunk curved ventral , abnormal
Show

 ZFA:0001117 post-vent region post-vent region curved ventral , abnormal
post-vent region quality , abnormal
Show

 ZFA:0001135 neural tube neural tube decreased thickness , abnormal
Show

 ZFA:0001161 pectoral fin pectoral fin decreased size , abnormal
pectoral fin quality , abnormal
pectoral fin decreased length , abnormal
pectoral fin variability of size , abnormal
pectoral fin cleithrum decreased length , abnormal
pectoral fin scapulocoracoid decreased size , abnormal
pectoral fin cleithrum morphology , abnormal
pectoral fin scapulocoracoid absent , abnormal
Show

 ZFA:0001177 roof plate spinal cord region roof plate spinal cord region cell projection decreased length , abnormal
Show

 ZFA:0001439 anatomical system anatomical system quality , abnormal
Show

 ZFA:0001456 pectoral fin endoskeletal disc pectoral fin endoskeletal disc absent , abnormal
pectoral fin endoskeletal disc decreased size , abnormal
Show

 ZFA:0001499 esophageal epithelium esophageal epithelium disorganized , abnormal
esophageal epithelium epithelial cell differentiation disrupted , abnormal
Show

 ZFA:0001557 pronephric glomerulus pronephric glomerulus increased amount , abnormal
pronephric glomerulus mislocalised laterally , abnormal
Show

 ZFA:0005057 epicardium epicardium absent , abnormal
Show

 ZFA:0005061 ventricular myocardium ventricular myocardium decreased thickness , abnormal
Show

 ZFA:0005147 regenerating tissue regenerating tissue cardiac muscle cell proliferation decreased occurrence , abnormal
Show

 ZFA:0005316 fin fold pectoral fin bud fin fold pectoral fin bud disorganized , abnormal
Show

 ZFA:0005317 pectoral fin fold pectoral fin fold absent , abnormal
Show

 ZFA:0005335 swim bladder bud swim bladder bud aplastic , abnormal
Show

 ZFA:0005545 pectoral fin actinotrichium pectoral fin actinotrichium decreased size , abnormal
pectoral fin actinotrichium absent , abnormal
Show

 ZFA:0005754 primary islet primary islet absent , abnormal
Show

 ZFA:0009053 sensory neuron sensory neuron morphology , abnormal
sensory neuron mislocalised , abnormal
Show

 ZFA:0009096 endocrine cell endocrine cell decreased amount , abnormal
Show

 ZFA:0009116 slow muscle cell slow muscle cell decreased amount , abnormal
slow muscle cell nucleus decreased amount , abnormal
Show

 ZFA:0009117 fast muscle cell fast muscle cell absent , abnormal
Show

 ZFA:0009150 Rohon-Beard neuron Rohon-Beard neuron morphology , abnormal
Show

 ZFA:0009262 retinal cone cell retinal cone cell irregular spatial pattern , abnormal
retinal cone cell decreased amount , abnormal
Show

 ZFA:0009316 cardiac muscle cell cardiac muscle cell decreased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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