ENSDARG00000058733


Danio rerio

Features
Gene ID: ENSDARG00000058733
  
Biological name :ihha
  
Synonyms : ihha / Indian hedgehog homolog a
  
Possible biological names infered from orthology : IHH / indian hedgehog / P97812 / Q14623
  
Species: Danio rerio
  
Chr. number: 9
Strand: 1
Band:
Gene start: 7358749
Gene end: 7367278
  
Corresponding Affymetrix probe sets: DrAffx.2.93.S1_at (Zebrafish Array)   NM_001034993_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000076101
NCBI entrez gene - 619520     See in Manteia.
RefSeq - NM_001034993
RefSeq Peptide - NP_001030165
swissprot - B0S8K0
ZFIN ID - ZDB-GENE-051010-1
Ensembl - ENSDARG00000058733
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IHHENSGALG00000011347Gallus gallus
 IHHENSG00000163501Homo sapiens
 IhhENSMUSG00000006538Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ihhb / Indian hedgehog homolog b / IHH* / Q14623* / P97812* / indian hedgehog*ENSDARG0000005881566
shha / Q92008 / sonic hedgehog aENSDARG0000006856761
shhb / Q90419 / sonic hedgehog bENSDARG0000003886758
dhh / desert hedgehog / O43323* / Q61488* / Desert hedgehog protein Desert hedgehog protein N-product Desert hedgehog protein C-product*ENSDARG0000003706247


Protein motifs (from Interpro)
Interpro ID Name
 IPR000320  Hedgehog, N-terminal signalling domain
 IPR001657  Hedgehog protein
 IPR001767  Hedgehog protein, Hint domain
 IPR003586  Hint domain C-terminal
 IPR003587  Hint domain N-terminal
 IPR006141  Intein N-terminal splicing region
 IPR009045  Hedgehog signalling/DD-peptidase zinc-binding domain superfamily
 IPR028992  Hedgehog/Intein (Hint) domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001649 osteoblast differentiation IMP
 biological_processGO:0001957 intramembranous ossification IMP
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007224 smoothened signaling pathway IMP
 biological_processGO:0007267 cell-cell signaling IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0016539 intein-mediated protein splicing IEA
 biological_processGO:0048794 swim bladder development IMP
 biological_processGO:0048795 swim bladder morphogenesis IMP
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Hedgehog ligand biogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000076 swim bladder swim bladder decreased size , abnormal
swim bladder epithelium decreased size , abnormal
swim bladder hypoplastic , abnormal
swim bladder mesenchyme decreased size , abnormal
swim bladder mesenchyme disorganized , abnormal
swim bladder smooth muscle aplastic , abnormal
swim bladder mesothelial cell decreased amount , abnormal
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 ZFA:0000112 gut gut neuron absent , abnormal
gut mesenchyme decreased size , abnormal
Show

 ZFA:0000140 pancreas pancreas morphology , abnormal
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 ZFA:0000250 opercle opercle antero-ventral margin has fewer parts of type osteoblast , abnormal
opercle decreased size , abnormal
opercle malformed , abnormal
opercle postero-ventral margin has fewer parts of type osteoblast , abnormal
opercle postero-ventral margin decreased length , abnormal
opercle antero-ventral margin has fewer parts of type bone tissue , abnormal
opercle dorsal-ventral axis decreased length , abnormal
opercle fused with subopercle , abnormal
opercle fused with interopercle , abnormal
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 ZFA:0000674 interopercle interopercle fused with subopercle , abnormal
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 ZFA:0001205 Meckel s cartilage Meckels cartilage osteoblast decreased amount , abnormal
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 ZFA:0001229 pharyngeal arch 7 skeleton pharyngeal arch 7 skeleton osteoclast undifferentiated , abnormal
pharyngeal arch 7 skeleton osteoclast poorly differentiated , abnormal
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 ZFA:0001277 anterior chamber swim bladder anterior chamber swim bladder absent , abnormal
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 ZFA:0001400 ceratohyal cartilage ceratohyal cartilage osteoblast absent , abnormal
ceratohyal cartilage cartilaginous , abnormal
ceratohyal cartilage morphology , abnormal
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 ZFA:0001430 pneumatic duct pneumatic duct decreased size , abnormal
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 ZFA:0001635 intramembranous bone intramembranous bone has extra parts of type branchiostegal ray , abnormal
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 ZFA:0005123 gut epithelium gut epithelium decreased size , abnormal
Show

 ZFA:0005124 intestinal epithelium intestinal epithelium decreased size , abnormal
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 ZFA:0005335 swim bladder bud swim bladder bud hypoplastic , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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