ENSDARG00000068996


Danio rerio

Features
Gene ID: ENSDARG00000068996
  
Biological name :hist2h2l
  
Synonyms : hist2h2l / histone 2, H2, like / Q6PC60
  
Possible biological names infered from orthology : HIST1H2BA / histone cluster 1 H2B family member a / Histone H2B type 1-A / P70696 / Q96A08
  
Species: Danio rerio
  
Chr. number: 10
Strand: -1
Band:
Gene start: 29815644
Gene end: 29816467
  
Corresponding Affymetrix probe sets: Dr.24294.1.A1_at (Zebrafish Array)   Dr.5231.1.S1_at (Zebrafish Array)   NM_200117_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000055912
NCBI entrez gene - 386920     See in Manteia.
RefSeq - NM_200117
RefSeq Peptide - NP_956411
swissprot - Q6PC60
ZFIN ID - ZDB-GENE-031118-36
Ensembl - ENSDARG00000068996
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q9PSW9ENSGALG00000030567Gallus gallus
 Q96A08ENSG00000146047Homo sapiens
 P70696ENSMUSG00000050799Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
si:ch211-113a14.22 / H2BFM* / H2BFS* / Q7Z2G1* / Q6ZWY9* / Q64525* / Q64524* / Q64478* / Q64475* / Q5QNW6* / Q16778* / P62807* / P58876* / P57053* / P33778* / P23527* / P10854* / P10853* / ...ENSDARG0000011489594
CU302436.1 / H2BFM* / H2BFS* / Q7Z2G1* / Q6ZWY9* / Q64525* / Q64524* / Q64478* / Q64475* / Q5QNW6* / Q16778* / P62807* / P58876* / P57053* / P33778* / P23527* / P10854* / P10853* / P0C1H6* ...ENSDARG0000011196494
zgc:112234 / H2BFM* / H2BFS* / Q7Z2G1* / Q6ZWY9* / Q64525* / Q64524* / Q64478* / Q64475* / Q5QNW6* / Q16778* / P62807* / P58876* / P57053* / P33778* / P23527* / P10854* / P10853* / P0C1H6* ...ENSDARG0000009951494
si:dkey-261m9.6 / H2BFM* / H2BFS* / Q7Z2G1* / Q6ZWY9* / Q64525* / Q64524* / Q64478* / Q64475* / Q5QNW6* / Q16778* / P62807* / P58876* / P57053* / P33778* / P23527* / P10854* / P10853* / P0C...ENSDARG0000011665494
CR354435.2 / H2BFM* / H2BFS* / Q7Z2G1* / Q6ZWY9* / Q64525* / Q64524* / Q64478* / Q64475* / Q5QNW6* / Q16778* / P62807* / P58876* / P57053* / P33778* / P23527* / P10854* / P10853* / P0C1H6* ...ENSDARG0000010973794
zgc:112234 / H2BFM* / H2BFS* / Q7Z2G1* / Q6ZWY9* / Q64525* / Q64524* / Q64478* / Q64475* / Q5QNW6* / Q16778* / P62807* / P58876* / P57053* / P33778* / P23527* / P10854* / P10853* / P0C1H6* ...ENSDARG0000010534094
zgc:112234 / H2BFM* / H2BFS* / Q7Z2G1* / Q6ZWY9* / Q64525* / Q64524* / Q64478* / Q64475* / Q5QNW6* / Q16778* / P62807* / P58876* / P57053* / P33778* / P23527* / P10854* / P10853* / P0C1H6* ...ENSDARG0000010458894
zgc:112234 / H2BFM* / H2BFS* / Q7Z2G1* / Q6ZWY9* / Q64525* / Q64524* / Q64478* / Q64475* / Q5QNW6* / Q16778* / P62807* / P58876* / P57053* / P33778* / P23527* / P10854* / P10853* / P0C1H6* ...ENSDARG0000010550794
zgc:112234 / H2BFM* / H2BFS* / Q7Z2G1* / Q6ZWY9* / Q64525* / Q64524* / Q64478* / Q64475* / Q5QNW6* / Q16778* / P62807* / P58876* / P57053* / P33778* / P23527* / P10854* / P10853* / P0C1H6* ...ENSDARG0000010280694
zgc:112234 / H2BFM* / H2BFS* / Q7Z2G1* / Q6ZWY9* / Q64525* / Q64524* / Q64478* / Q64475* / Q5QNW6* / Q16778* / P62807* / P58876* / P57053* / P33778* / P23527* / P10854* / P10853* / P0C1H6* ...ENSDARG0000011193494
zgc:171759 / H2BFM* / H2BFS* / Q7Z2G1* / Q6ZWY9* / Q64525* / Q64524* / Q64478* / Q64475* / Q5QNW6* / Q16778* / P62807* / P58876* / P57053* / P33778* / P23527* / P10854* / P10853* / P0C1H6* ...ENSDARG0000011593894
zgc:194989 / H2BFM* / H2BFS* / Q7Z2G1* / Q6ZWY9* / Q64525* / Q64524* / Q64478* / Q64475* / Q5QNW6* / Q16778* / P62807* / P58876* / P57053* / P33778* / P23527* / P10854* / P10853* / P0C1H6* ...ENSDARG0000011440594
CU302436.4 / H2BFM* / H2BFS* / Q7Z2G1* / Q6ZWY9* / Q64525* / Q64524* / Q64478* / Q64475* / Q5QNW6* / Q16778* / P62807* / P58876* / P57053* / P33778* / P23527* / P10854* / P10853* / P0C1H6* ...ENSDARG0000011419594
Q5BJA5 / zgc:173587 / H2BFM* / H2BFS* / Q64525* / Q64524* / Q64478* / Q64475* / Q5QNW6* / Q16778* / P62807* / P58876* / P57053* / P33778* / P23527* / P10854* / P10853* / P0C1H6* / P06899* /...ENSDARG0000007548294
si:ch211-113a14.22 / H2BFM* / H2BFS* / Q7Z2G1* / Q6ZWY9* / Q64525* / Q64524* / Q64478* / Q64475* / Q5QNW6* / Q16778* / P62807* / P58876* / P57053* / P33778* / P23527* / P10854* / P10853* / ...ENSDARG0000010539794
zgc:112234 / H2BFM* / H2BFS* / Q7Z2G1* / Q6ZWY9* / Q64525* / Q64524* / Q64478* / Q64475* / Q5QNW6* / Q16778* / P62807* / P58876* / P57053* / P33778* / P23527* / P10854* / P10853* / P0C1H6* ...ENSDARG0000010539394
zgc:112234 / H2BFM* / H2BFS* / Q7Z2G1* / Q6ZWY9* / Q64525* / Q64524* / Q64478* / Q64475* / Q5QNW6* / Q16778* / P62807* / P58876* / P57053* / P33778* / P23527* / P10854* / P10853* / P0C1H6* ...ENSDARG0000010548394
Q5BJA5 / CR354435.1 / Histone H2B 1/2 / H2BFM* / H2BFS* / Q64478* / Q64475* / Q5QNW6* / Q16778* / P62807* / P58876* / P57053* / P33778* / P23527* / P10854* / P10853* / P0C1H6* / P06899* / ...ENSDARG0000007029794
hist1h2ba / histone cluster 1, H2ba / H2BFS* / H2BFM* / Q6ZWY9* / Q64525* / Q64524* / Q64478* / Q64475* / Q5QNW6* / Q16778* / P62807* / P58876* / P57053* / P33778* / P23527* / P10854* / P10...ENSDARG0000010937094
zgc:112234 / H2BFM* / H2BFS* / Q7Z2G1* / Q6ZWY9* / Q64525* / Q64524* / Q64478* / Q64475* / Q5QNW6* / Q16778* / P62807* / P58876* / P57053* / P33778* / P23527* / P10854* / P10853* / P0C1H6* ...ENSDARG0000010541494


Protein motifs (from Interpro)
Interpro ID Name
 IPR000558  Histone H2B
 IPR007125  Histone H2A/H2B/H3
 IPR009072  Histone-fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006334 nucleosome assembly IBA
 cellular_componentGO:0000786 nucleosome IEA
 cellular_componentGO:0000790 nuclear chromatin IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005694 chromosome IEA
 molecular_functionGO:0003677 DNA binding IBA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
PRC2 methylates histones and DNA
Condensation of Prophase Chromosomes
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
HATs acetylate histones
SIRT1 negatively regulates rRNA expression
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
Transcriptional regulation by small RNAs
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Ub-specific processing proteases
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
G2/M DNA damage checkpoint
RNA Polymerase I Promoter Opening
RNA Polymerase I Chain Elongation
E3 ubiquitin ligases ubiquitinate target proteins
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000023903 atf2 / activating transcription factor 2 / P15336* / P16951* / Cyclic AMP-dependent transcription factor ATF-2 *  / reaction






 

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