ENSG00000146047


Homo sapiens

Features
Gene ID: ENSG00000146047
  
Biological name :HIST1H2BA
  
Synonyms : HIST1H2BA / histone cluster 1 H2B family member a / Q96A08
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: 1
Band: p22.2
Gene start: 25726777
Gene end: 25727292
  
Corresponding Affymetrix probe sets: 241519_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000274764
NCBI entrez gene - 255626     See in Manteia.
OMIM - 609904
RefSeq - NM_170610
RefSeq Peptide - NP_733759
swissprot - Q96A08
Ensembl - ENSG00000146047
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q6PC60ENSDARG00000068996Danio rerio
 P0C1H3ENSGALG00000027594Gallus gallus
 P0C1H3ENSGALG00000042263Gallus gallus
 P0C1H3ENSGALG00000027571Gallus gallus
 P0C1H3ENSGALG00000037934Gallus gallus
 P0C1H3ENSGALG00000039722Gallus gallus
 P0C1H5ENSGALG00000036908Gallus gallus
 P70696ENSMUSG00000050799Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q16778 / HIST2H2BE / histone cluster 2 H2B family member eENSG0000018467886
Q99880 / HIST1H2BL / histone cluster 1 H2B family member lENSG0000018513086
Q8N257 / HIST3H2BB / histone cluster 3 H2B family member bENSG0000019689086
P33778 / HIST1H2BB / histone cluster 1 H2B family member bENSG0000027641086
Q99877 / HIST1H2BN / histone cluster 1 H2B family member nENSG0000023382286
P62807 / HIST1H2BE / histone cluster 1 H2B family member eENSG0000027429085
P62807 / HIST1H2BI / histone cluster 1 H2B family member iENSG0000027858885
P23527 / HIST1H2BO / histone cluster 1 H2B family member oENSG0000027464185
P62807 / HIST1H2BF / histone cluster 1 H2B family member fENSG0000027722485
P62807 / HIST1H2BC / histone cluster 1 H2B family member cENSG0000018059685
P62807 / HIST1H2BG / histone cluster 1 H2B family member gENSG0000027380285
P58876 / HIST1H2BD / histone cluster 1 H2B family member dENSG0000015837385
P06899 / HIST1H2BJ / histone cluster 1 H2B family member jENSG0000012463585
O60814 / HIST1H2BK / histone cluster 1 H2B family member kENSG0000019790384
Q99879 / HIST1H2BM / histone cluster 1 H2B family member mENSG0000027370384
Q5QNW6 / HIST2H2BF / histone cluster 2 H2B family member fENSG0000020381484
Q93079 / HIST1H2BH / histone cluster 1 H2B family member hENSG0000027571384
H2BFS / H2B histone family member SENSG0000027455983
H2BFS / P57053 / H2B histone family member SENSG0000023428983
AC021097.2ENSG0000028548063


Protein motifs (from Interpro)
Interpro ID Name
 IPR000558  Histone H2B
 IPR007125  Histone H2A/H2B/H3
 IPR009072  Histone-fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006334 nucleosome assembly IEA
 biological_processGO:0006337 nucleosome disassembly IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0016567 protein ubiquitination TAS
 biological_processGO:0031639 plasminogen activation IEA
 biological_processGO:0035093 spermatogenesis, exchange of chromosomal proteins IEA
 biological_processGO:0051099 positive regulation of binding IEA
 biological_processGO:0071674 mononuclear cell migration IEA
 cellular_componentGO:0000784 nuclear chromosome, telomeric region HDA
 cellular_componentGO:0000786 nucleosome ISS
 cellular_componentGO:0000788 nuclear nucleosome IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0019897 extrinsic component of plasma membrane IEA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0003677 DNA binding IBA
 molecular_functionGO:0042393 histone binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Meiotic synapsis
Packaging Of Telomere Ends
Pre-NOTCH Transcription and Translation
Formation of the beta-catenin:TCF transactivating complex
PRC2 methylates histones and DNA
Condensation of Prophase Chromosomes
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
HDACs deacetylate histones
HATs acetylate histones
SIRT1 negatively regulates rRNA expression
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
DNA methylation
Transcriptional regulation by small RNAs
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Ub-specific processing proteases
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
Deposition of new CENPA-containing nucleosomes at the centromere
G2/M DNA damage checkpoint
RNA Polymerase I Promoter Opening
RNA Polymerase I Chain Elongation
E3 ubiquitin ligases ubiquitinate target proteins
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Estrogen-dependent gene expression
Meiotic recombination
Amyloid fiber formation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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