ENSG00000185130


Homo sapiens

Features
Gene ID: ENSG00000185130
  
Biological name :HIST1H2BL
  
Synonyms : HIST1H2BL / histone cluster 1 H2B family member l / Q99880
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: -1
Band: p22.1
Gene start: 27807444
Gene end: 27807931
  
Corresponding Affymetrix probe sets: 207611_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000366618
NCBI entrez gene - 8340     See in Manteia.
OMIM - 602800
RefSeq - NM_003519
RefSeq Peptide - NP_003510
swissprot - Q99880
Ensembl - ENSG00000185130
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CR354435.2ENSDARG00000109737Danio rerio
 CU302436.1ENSDARG00000111964Danio rerio
 CU302436.4ENSDARG00000114195Danio rerio
 FP236812.3ENSDARG00000114180Danio rerio
 FP340257.2ENSDARG00000113763Danio rerio
 hist1h2baENSDARG00000109370Danio rerio
 Q5BJA5ENSDARG00000075482Danio rerio
 Q5BJA5ENSDARG00000070297Danio rerio
 Q5BJA5ENSDARG00000104501Danio rerio
 si:ch211-113a14.11ENSDARG00000086591Danio rerio
 si:ch211-113a14.22ENSDARG00000114895Danio rerio
 si:ch211-113a14.22ENSDARG00000070289Danio rerio
 si:ch211-113a14.22ENSDARG00000105397Danio rerio
 si:dkey-108k21.11ENSDARG00000112561Danio rerio
 si:dkey-23a13.22ENSDARG00000105384Danio rerio
 si:dkey-261m9.19ENSDARG00000114125Danio rerio
 si:dkey-261m9.6ENSDARG00000116654Danio rerio
 zgc:112234ENSDARG00000105393Danio rerio
 zgc:112234ENSDARG00000078941Danio rerio
 zgc:112234ENSDARG00000111934Danio rerio
 zgc:112234ENSDARG00000105507Danio rerio
 zgc:112234ENSDARG00000105483Danio rerio
 zgc:112234ENSDARG00000105340Danio rerio
 zgc:112234ENSDARG00000105414Danio rerio
 zgc:112234ENSDARG00000105468Danio rerio
 zgc:112234ENSDARG00000104588Danio rerio
 zgc:112234ENSDARG00000102806Danio rerio
 zgc:112234ENSDARG00000099514Danio rerio
 zgc:114046ENSDARG00000091728Danio rerio
 zgc:171759ENSDARG00000100259Danio rerio
 zgc:171759ENSDARG00000115938Danio rerio
 zgc:173585ENSDARG00000089039Danio rerio
 zgc:194989ENSDARG00000114405Danio rerio


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P62807 / HIST1H2BG / histone cluster 1 H2B family member gENSG0000027380298
P62807 / HIST1H2BC / histone cluster 1 H2B family member cENSG0000018059698
P58876 / HIST1H2BD / histone cluster 1 H2B family member dENSG0000015837398
P62807 / HIST1H2BI / histone cluster 1 H2B family member iENSG0000027858898
Q93079 / HIST1H2BH / histone cluster 1 H2B family member hENSG0000027571398
Q99877 / HIST1H2BN / histone cluster 1 H2B family member nENSG0000023382298
O60814 / HIST1H2BK / histone cluster 1 H2B family member kENSG0000019790398
P62807 / HIST1H2BF / histone cluster 1 H2B family member fENSG0000027722498
Q16778 / HIST2H2BE / histone cluster 2 H2B family member eENSG0000018467898
P62807 / HIST1H2BE / histone cluster 1 H2B family member eENSG0000027429098
P23527 / HIST1H2BO / histone cluster 1 H2B family member oENSG0000027464197
P06899 / HIST1H2BJ / histone cluster 1 H2B family member jENSG0000012463597
Q5QNW6 / HIST2H2BF / histone cluster 2 H2B family member fENSG0000020381497
P33778 / HIST1H2BB / histone cluster 1 H2B family member bENSG0000027641096
H2BFS / H2B histone family member SENSG0000027455996
H2BFS / P57053 / H2B histone family member SENSG0000023428996
Q8N257 / HIST3H2BB / histone cluster 3 H2B family member bENSG0000019689095
Q99879 / HIST1H2BM / histone cluster 1 H2B family member mENSG0000027370395
Q96A08 / HIST1H2BA / histone cluster 1 H2B family member aENSG0000014604787
AC021097.2ENSG0000028548063


Protein motifs (from Interpro)
Interpro ID Name
 IPR000558  Histone H2B
 IPR007125  Histone H2A/H2B/H3
 IPR009072  Histone-fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006334 nucleosome assembly IBA
 biological_processGO:0016567 protein ubiquitination TAS
 cellular_componentGO:0000786 nucleosome NAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0003677 DNA binding IBA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Meiotic synapsis
Packaging Of Telomere Ends
Pre-NOTCH Transcription and Translation
Formation of the beta-catenin:TCF transactivating complex
PRC2 methylates histones and DNA
Condensation of Prophase Chromosomes
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
HDACs deacetylate histones
HATs acetylate histones
SIRT1 negatively regulates rRNA expression
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
DNA methylation
Transcriptional regulation by small RNAs
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Ub-specific processing proteases
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
Deposition of new CENPA-containing nucleosomes at the centromere
G2/M DNA damage checkpoint
RNA Polymerase I Promoter Opening
RNA Polymerase I Chain Elongation
E3 ubiquitin ligases ubiquitinate target proteins
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Estrogen-dependent gene expression
Meiotic recombination
Amyloid fiber formation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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