ENSDARG00000070787


Danio rerio

Features
Gene ID: ENSDARG00000070787
  
Biological name :jupa
  
Synonyms : junction plakoglobin a / jupa
  
Possible biological names infered from orthology : junction plakoglobin / JUP / P14923 / Q02257
  
Species: Danio rerio
  
Chr. number: 11
Strand: 1
Band:
Gene start: 11719575
Gene end: 11781911
  
Corresponding Affymetrix probe sets: Dr.25119.1.S1_s_at (Zebrafish Array)   NM_131177_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000026915
Ensembl peptide - ENSDARP00000075461
Ensembl peptide - ENSDARP00000156233
NCBI entrez gene - 30415     See in Manteia.
RefSeq - NM_131177
RefSeq Peptide - NP_571252
swissprot - F1QTT3
swissprot - Q7ZWH9
ZFIN ID - ZDB-GENE-991207-22
Ensembl - ENSDARG00000070787
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 JUPENSGALG00000017414Gallus gallus
 JUPENSG00000173801Homo sapiens
 JupENSMUSG00000001552Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
jupb / junction plakoglobin b / JUP* / P14923* / Q02257* / junction plakoglobin*ENSDARG0000005906773
ctnnb1 / catenin (cadherin-associated protein), beta 1 / P35222* / catenin beta 1*ENSDARG0000001457166
ctnnb2 / catenin, beta 2ENSDARG0000002347265


Protein motifs (from Interpro)
Interpro ID Name
 IPR000225  Armadillo
 IPR011989  Armadillo-like helical
 IPR013284  Beta-catenin
 IPR016024  Armadillo-type fold
 IPR030461  Junction plakoglobin/protein humpback-2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002159 desmosome assembly IEA
 biological_processGO:0003181 atrioventricular valve morphogenesis IMP
 biological_processGO:0003308 negative regulation of Wnt signaling pathway involved in heart development IGI
 biological_processGO:0007155 cell adhesion IC
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007507 heart development IMP
 biological_processGO:0030178 negative regulation of Wnt signaling pathway IMP
 biological_processGO:0034333 adherens junction assembly IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005913 cell-cell adherens junction IEA
 cellular_componentGO:0016342 catenin complex IEA
 cellular_componentGO:0030057 desmosome IDA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0005198 structural molecule activity IEA
 molecular_functionGO:0019903 protein phosphatase binding IBA
 molecular_functionGO:0045294 alpha-catenin binding IEA
 molecular_functionGO:0045296 cadherin binding IEA


Pathways (from Reactome)
Pathway description
Adherens junctions interactions
VEGFR2 mediated vascular permeability
Neutrophil degranulation
Keratinization
Formation of the cornified envelope


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000114 heart heart decreased size , abnormal
heart edematous , abnormal
heart cell-cell junction structure , abnormal
heart cell-cell junction decreased amount , abnormal
heart adherens junction composition , abnormal
heart adherens junction decreased amount , abnormal
heart desmosome decreased amount , abnormal
heart endothelial cell morphology , abnormal
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 ZFA:0001117 post-vent region post-vent region kinked , abnormal
Show

 ZFA:0009256 nucleate erythrocyte nucleate erythrocyte decreased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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