ENSDARG00000070801


Danio rerio

Features
Gene ID: ENSDARG00000070801
  
Biological name :opa1
  
Synonyms : opa1 / optic atrophy 1 (autosomal dominant) / Q5U3A7
  
Possible biological names infered from orthology : Dynamin-like 120 kDa protein, mitochondrial Dynamin-like 120 kDa protein, form S1 / O60313 / OPA1, mitochondrial dynamin like GTPase / P58281
  
Species: Danio rerio
  
Chr. number: 6
Strand: -1
Band:
Gene start: 36717985
Gene end: 36795219
  
Corresponding Affymetrix probe sets: Dr.23229.1.S1_at (Zebrafish Array)   Dr.2992.1.A1_at (Zebrafish Array)   NM_001007298_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000134977
Ensembl peptide - ENSDARP00000147583
Ensembl peptide - ENSDARP00000145882
Ensembl peptide - ENSDARP00000095031
Ensembl peptide - ENSDARP00000133518
NCBI entrez gene - 492332     See in Manteia.
RefSeq - NM_001007298
RefSeq Peptide - NP_001007299
swissprot - A0A0R4ILJ7
swissprot - A0A0R4IJ30
swissprot - Q5U3A7
ZFIN ID - ZDB-GENE-041114-7
Ensembl - ENSDARG00000070801
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 OPA1ENSGALG00000007150Gallus gallus
 OPA1ENSG00000198836Homo sapiens
 Opa1ENSMUSG00000038084Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001401  Dynamin, GTPase domain
 IPR022812  Dynamin superfamily
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR030381  Dynamin-type guanine nucleotide-binding (G) domain
 IPR033047  Dynamin-like 120kDa protein, mitochondrial


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000266 mitochondrial fission IBA
 biological_processGO:0003374 dynamin family protein polymerization involved in mitochondrial fission IBA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007005 mitochondrion organization IEA
 biological_processGO:0008053 mitochondrial fusion ISS
 biological_processGO:0043009 chordate embryonic development IMP
 biological_processGO:0046039 GTP metabolic process ISS
 biological_processGO:0055015 ventricular cardiac muscle cell development IMP
 biological_processGO:0061025 membrane fusion IBA
 biological_processGO:0070584 mitochondrion morphogenesis IMP
 biological_processGO:0097749 membrane tubulation ISS
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005743 mitochondrial inner membrane IEA
 cellular_componentGO:0005758 mitochondrial intermembrane space IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031966 mitochondrial membrane IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0008017 microtubule binding IBA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0070300 phosphatidic acid binding ISS
 molecular_functionGO:1901612 cardiolipin binding ISS


Pathways (from Reactome)
Pathway description
Regulation of Apoptosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000042 midbrain hindbrain boundary midbrain hindbrain boundary inconspicuous , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000084 yolk yolk edematous , abnormal
yolk increased size , abnormal
Show

 ZFA:0000107 eye eye decreased size , abnormal
eye edematous , abnormal
Show

 ZFA:0000110 fourth ventricle fourth ventricle increased size , abnormal
Show

 ZFA:0000114 heart heart decreased size , abnormal
Show

 ZFA:0001094 whole organism whole organism decreased length , abnormal
whole organism dead , abnormal
whole organism decreased amount , abnormal
Show

 ZFA:0001161 pectoral fin pectoral fin decreased size , abnormal
Show

 ZFA:0005145 muscle muscle contractile fiber disorganized , abnormal
Show

 ZFA:0009114 muscle cell muscle cell mitochondrion broken , abnormal
Show

 ZFA:0009256 nucleate erythrocyte nucleate erythrocyte accumulation heart , abnormal
Show

 ZFA:0009316 cardiac muscle cell cardiac muscle cell increased size , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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