ENSMUSG00000038084


Mus musculus

Features
Gene ID: ENSMUSG00000038084
  
Biological name :Opa1
  
Synonyms : Dynamin-like 120 kDa protein, mitochondrial Dynamin-like 120 kDa protein, form S1 / Opa1 / P58281
  
Possible biological names infered from orthology : O60313 / OPA1, mitochondrial dynamin like GTPase
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: B2
Gene start: 29579334
Gene end: 29654884
  
Corresponding Affymetrix probe sets: 10434888 (MoGene1.0st)   1418768_at (Mouse Genome 430 2.0 Array)   1434890_at (Mouse Genome 430 2.0 Array)   1449214_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000124739
Ensembl peptide - ENSMUSP00000036993
Ensembl peptide - ENSMUSP00000123880
Ensembl peptide - ENSMUSP00000124029
Ensembl peptide - ENSMUSP00000124223
NCBI entrez gene - 74143     See in Manteia.
MGI - MGI:1921393
RefSeq - XM_006522655
RefSeq - XM_006522654
RefSeq - XM_006522656
RefSeq - NM_001199177
RefSeq - NM_133752
RefSeq - XM_006522657
RefSeq Peptide - NP_598513
RefSeq Peptide - NP_001186106
swissprot - P58281
swissprot - F6U775
swissprot - E0CXD1
swissprot - H7BX01
Ensembl - ENSMUSG00000038084
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 opa1ENSDARG00000070801Danio rerio
 OPA1ENSGALG00000007150Gallus gallus
 OPA1ENSG00000198836Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001401  Dynamin, GTPase domain
 IPR022812  Dynamin superfamily
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR030381  Dynamin-type guanine nucleotide-binding (G) domain
 IPR033047  Dynamin-like 120kDa protein, mitochondrial


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000002 mitochondrial genome maintenance IEA
 biological_processGO:0000266 mitochondrial fission IBA
 biological_processGO:0001843 neural tube closure IMP
 biological_processGO:0003374 dynamin family protein polymerization involved in mitochondrial fission IBA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007005 mitochondrion organization IEA
 biological_processGO:0007007 inner mitochondrial membrane organization IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0007601 visual perception IEA
 biological_processGO:0008053 mitochondrial fusion IEA
 biological_processGO:0010636 positive regulation of mitochondrial fusion IEA
 biological_processGO:0014042 positive regulation of neuron maturation IEA
 biological_processGO:0014850 response to muscle activity IEA
 biological_processGO:0031667 response to nutrient levels IEA
 biological_processGO:0036444 calcium import into the mitochondrion IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0046039 GTP metabolic process IEA
 biological_processGO:0048312 intracellular distribution of mitochondria IEA
 biological_processGO:0050896 response to stimulus IEA
 biological_processGO:0051259 protein complex oligomerization IEA
 biological_processGO:0051602 response to electrical stimulus IEA
 biological_processGO:0060041 retina development in camera-type eye IEA
 biological_processGO:0061003 positive regulation of dendritic spine morphogenesis IEA
 biological_processGO:0070584 mitochondrion morphogenesis IEA
 biological_processGO:0071333 cellular response to glucose stimulus IEA
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:0090102 cochlea development IEA
 biological_processGO:0090201 negative regulation of release of cytochrome c from mitochondria IEA
 biological_processGO:0090398 cellular senescence IEA
 biological_processGO:0097749 membrane tubulation IEA
 biological_processGO:1900006 positive regulation of dendrite development IEA
 biological_processGO:1900078 positive regulation of cellular response to insulin stimulus IEA
 biological_processGO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IEA
 biological_processGO:1905232 cellular response to L-glutamate IEA
 biological_processGO:2001243 negative regulation of intrinsic apoptotic signaling pathway IMP
 biological_processGO:2001275 positive regulation of glucose import in response to insulin stimulus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005741 mitochondrial outer membrane IEA
 cellular_componentGO:0005743 mitochondrial inner membrane IDA
 cellular_componentGO:0005758 mitochondrial intermembrane space IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030061 mitochondrial crista IEA
 cellular_componentGO:0030425 dendrite IDA
 cellular_componentGO:0031314 extrinsic component of mitochondrial inner membrane IEA
 cellular_componentGO:0031966 mitochondrial membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0008017 microtubule binding IBA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019900 kinase binding IEA
 molecular_functionGO:0070300 phosphatidic acid binding IEA
 molecular_functionGO:1901612 cardiolipin binding IEA


Pathways (from Reactome)
Pathway description
Regulation of Apoptosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000358 abnormal cell content/ morphology "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Braftm1Mmcm/Braf+,Cdkn2atm4Rdp/Cdkn2atm4Rdp
Genetic Background: involves: 129P2/OlaHsd

 MP:0000428 abnormal craniofacial morphology "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ptk2tm1.1Guan/Ptk2tm1.1Guan,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Opa1M1Bewi/Opa1+
Genetic Background: involves: C3HeB/FeJ * C57BL/6

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Ift172wim/Ift172wim
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: Opa1lilr3/Opa1lilr3
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0001330 abnormal optic nerve morphology "malformation, misprojection or atrophy in the second cranial nerve which is responsible for conveying visual information from the retina to the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Braftm1Mmcm/Braf+,Cdkn2atm4Rdp/Cdkn2atm4Rdp
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Opa1M1Bewi/Opa1+
Genetic Background: involves: C3HeB/FeJ * C57BL/6

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Opa1M1Bewi/Opa1+
Genetic Background: involves: C3HeB/FeJ * C57BL/6

 MP:0001413 abnormal response to new environment "altered investigative behavior from controls in reactions associated with placing an animal in a new location" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Braftm1Mmcm/Braf+,Cdkn2atm4Rdp/Cdkn2atm4Rdp
Genetic Background: involves: 129P2/OlaHsd

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Opa1M1Bewi/Opa1+
Genetic Background: involves: C3HeB/FeJ * C57BL/6

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Braftm1Mmcm/Braf+,Cdkn2atm4Rdp/Cdkn2atm4Rdp
Genetic Background: involves: 129P2/OlaHsd

 MP:0001691 abnormal somite shape "atypical characteristic surface configuration of a segmental mass along the notochord of the developing embryo" [J:37888]
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Allelic Composition: Opa1lilr3/Opa1lilr3
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Braftm1Mmcm/Braf+,Cdkn2atm4Rdp/Cdkn2atm4Rdp
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Opa1lilr3/Opa1lilr3
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0001700 abnormal embryo turning "atypical axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (Mus:E8.5-E9.5) such that the curvature of the entire trunk region is reversed and the neural ectoderm moves to the convex region and the midgut region becomes located in the concave region" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Braftm1Mmcm/Braf+,Cdkn2atm4Rdp/Cdkn2atm4Rdp
Genetic Background: involves: 129P2/OlaHsd

 MP:0001701 incomplete embryo turning "arrest of the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [J:62571]
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Allelic Composition: Opa1lilr3/Opa1lilr3
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
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Allelic Composition: Mlh1tm1Rak/Mlh1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Opa1lilr3/Opa1lilr3
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0002090 abnormal vision "inability or decreased ability to see " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Braftm1Mmcm/Braf+,Cdkn2atm4Rdp/Cdkn2atm4Rdp
Genetic Background: involves: 129P2/OlaHsd

 MP:0002183 gliosis "increased growth pattern of neuroglia in a damaged area of the brain or spinal cord" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Opa1M1Bewi/Opa1+
Genetic Background: involves: C3HeB/FeJ * C57BL/6

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Opa1tm1.2Hise/Opa1tm1.2Hise
Genetic Background: involves: 129S/SvEv * C57BL/6 * FVB/N

 MP:0002884 abnormal branchial arches "malformation or anomaly in the transient structures of the embryo that develop into regions of the head, neck and ears" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Opa1lilr3/Opa1lilr3
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Opa1tm1.2Hise/Opa1tm1.2Hise
Genetic Background: involves: 129S/SvEv * C57BL/6 * FVB/N

 MP:0003213 resistance to age related obesity "reduced probability of excessive weight gain that is progressive with age" [RGD:Rat Genome Database submission]
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Allelic Composition: Opa1M1Bewi/Opa1+
Genetic Background: involves: C3HeB/FeJ * C57BL/6

 MP:0003232 abnormal forebrain development "anomaly in the formation or patterning of the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [J:93081, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Braftm1Mmcm/Braf+,Cdkn2atm4Rdp/Cdkn2atm4Rdp
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Opa1Q285X/Opa1Q285X
Genetic Background: involves: C3HeB/FeJ * C57BL/6JCrl

 MP:0003339 decreased number of pancreatic beta cells "fewer than normal number of the cells of the pancreas that secrete insulin" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Opa1tm1.1Hise/Opa1tm1.2Hise,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA * SJL

 MP:0003562 abnormal beta cell physiology "anomaly in the function of the insulin-producing cells of the islets of Langerhans in the pancreas" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Opa1tm1.1Hise/Opa1tm1.2Hise,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA * SJL

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Braftm1Mmcm/Braf+,Cdkn2atm4Rdp/Cdkn2atm4Rdp
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Opa1Q285X/Opa1Q285X
Genetic Background: involves: C3HeB/FeJ * C57BL/6JCrl

Allelic Composition: Opa1M1Bewi/Opa1M1Bewi
Genetic Background: involves: C3HeB/FeJ * C57BL/6

Allelic Composition: Opa1lilr3/Opa1lilr3
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0005217 abnormal pancreatic beta cell morphology "malformation of the cells of the pancreas that secrete insulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Opa1tm1.2Hise/Opa1tm1.2Hise
Genetic Background: involves: 129S/SvEv * C57BL/6 * FVB/N

 MP:0005221 abnormal rostral-caudal axis patterning "anomaly in the development or formation of the axis that runs from the head to the tail of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Opa1lilr3/Opa1lilr3
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0005290 decreased oxygen consumption "less than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Opa1tm1.2Hise/Opa1tm1.2Hise
Genetic Background: involves: 129S/SvEv * C57BL/6 * FVB/N

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Opa1tm1.2Hise/Opa1tm1.2Hise
Genetic Background: involves: 129S/SvEv * C57BL/6 * FVB/N

 MP:0005551 abnormal eye electrophysiology "abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
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Allelic Composition: Braftm1Mmcm/Braf+,Cdkn2atm4Rdp/Cdkn2atm4Rdp
Genetic Background: involves: 129P2/OlaHsd

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Opa1tm1.2Hise/Opa1tm1.2Hise
Genetic Background: involves: 129S/SvEv * C57BL/6 * FVB/N

 MP:0006035 abnormal mitochondrial morphology "anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Opa1lilr3/Opa1lilr3
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Opa1tm1.1Hise/Opa1tm1.2Hise,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA * SJL

 MP:0006036 abnormal mitochondrial physiology 
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Allelic Composition: Csf1tm1.1(CSF1)Flv/Csf1tm1.1(CSF1)Flv,Csf2/Il3tm1.1(CSF2,IL3)Flv/Csf2/Il3tm1.1(CSF2,IL3)Flv,Il2rgtm1.1Flv/Il2rgtm1.1Flv,Rag2tm1.1Flv/Rag2tm1.1Flv,Tg(SIRPA)1Flv/0,Thpotm1.1(TPO)Flv/Thpotm1.1(TPO)Flv
Genetic Background: involves: 129S4/SvJae * BALB/cAnNTac

 MP:0006303 abnormal retinal nerve fiber layer morphology "malformation of the layer of the retina formed by expansion of the fibers of the optic nerve" [ISBN:0-914294-08-3 "Gray s Anatomy", J:67382, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Opa1M1Bewi/Opa1+
Genetic Background: involves: C3HeB/FeJ * C57BL/6

 MP:0006309 decreased retinal ganglion cell number "reduced number of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Opa1M1Bewi/Opa1+
Genetic Background: involves: C3HeB/FeJ * C57BL/6

 MP:0008513 thin retinal inner plexiform layer "reduced thickness of the retinal cell layer where bipolar and amacrine cell axons synapse with ganglion cell dendrites" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Opa1M1Bewi/Opa1+
Genetic Background: involves: C3HeB/FeJ * C57BL/6

 MP:0009172 small pancreatic islets "decrease in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
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Allelic Composition: Opa1tm1.1Hise/Opa1tm1.2Hise,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA * SJL

 MP:0009901 abnormal frontonasal prominence morphology "any structural anomaly of an unpaired facial process in the embryo formed from the tissues surrounding the forebrain vesicle that develops into the forehead and bridge of the nose/snout" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Opa1lilr3/Opa1lilr3
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Opa1M1Bewi/Opa1+
Genetic Background: involves: C3HeB/FeJ * C57BL/6

 MP:0010748 abnormal visual evoked potential "anomaly in the electroencephalographic pattern recorded from the occipital area generated in response to retinal stimulation such as flashing lights or inverting a contrasting image; may be used to evaluate optic nerve damage or visual perception" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Braftm1Mmcm/Braf+,Cdkn2atm4Rdp/Cdkn2atm4Rdp
Genetic Background: involves: 129P2/OlaHsd

 MP:0010955 abnormal respiratory electron transport chain "anomaly in the process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient" [GO:0022904]
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Allelic Composition: Opa1tm1.1Hise/Opa1tm1.2Hise,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA * SJL

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Opa1M1Bewi/Opa1M1Bewi
Genetic Background: involves: C3HeB/FeJ * C57BL/6

Allelic Composition: Opa1tm1.2Hise/Opa1tm1.2Hise
Genetic Background: involves: 129S/SvEv * C57BL/6 * FVB/N

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Ift172wim/Ift172wim
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: Opa1Q285X/Opa1Q285X
Genetic Background: involves: C3HeB/FeJ * C57BL/6JCrl

Allelic Composition: Opa1lilr3/Opa1lilr3
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0011635 abnormal mitochondrial crista morphology "Any of the inward folds of the mitochondrial inner membrane; crista number, extent, and shape differ in mitochondria from different tissues and organisms; crista appear to be devices for increasing the surface area of the mitochondrial inner membrane, where the enzymes of electron transport and oxidative phosphorylation are found; the shape can vary with the respiratory state of the mitochondria" [GO:0030061]
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Allelic Composition: Opa1tm1.1Hise/Opa1tm1.2Hise,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA * SJL

Allelic Composition: Opa1tm1Lsc/Opa1tm1Lsc
Genetic Background: involves: C57BL/6J

 MP:0011732 decreased somite size "reduced size of any of the segmental masses along the notochord of the developing embryo" [MGI:smb]
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Allelic Composition: Opa1lilr3/Opa1lilr3
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0011820 decreased pancreatic beta cell proliferation "reduction in the ability of the cells that secrete insulin and are located towards the center of the islets of Langerhans in the pancreas to undergo expansion by cell division" [CL:0000169]
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Allelic Composition: Opa1tm1.1Hise/Opa1tm1.2Hise,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000035069 Oma1 / Q9D8H7 / Metalloendopeptidase OMA1, mitochondrial / Q96E52* / OMA1 zinc metallopeptidase*  / reaction






 

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