ENSDARG00000076229


Danio rerio

Features
Gene ID: ENSDARG00000076229
  
Biological name :mkl1b
  
Synonyms : megakaryoblastic leukemia (translocation) 1b / mkl1b
  
Possible biological names infered from orthology : megakaryoblastic leukemia (translocation) 1 / MKL1 / MKL/myocardin-like protein 1 / Q8K4J6 / Q969V6
  
Species: Danio rerio
  
Chr. number: 12
Strand: 1
Band:
Gene start: 18718065
Gene end: 18787459
  
Corresponding Affymetrix probe sets: Dr.8471.1.A1_at (Zebrafish Array)   Dr.8471.2.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000127385
Ensembl peptide - ENSDARP00000127187
Ensembl peptide - ENSDARP00000127226
Ensembl peptide - ENSDARP00000127290
NCBI entrez gene - 559638     See in Manteia.
RefSeq - NM_001201558
RefSeq Peptide - NP_001188487
swissprot - E7F9J6
swissprot - U3JAC1
swissprot - U3JAF8
swissprot - U3JAM2
ZFIN ID - ZDB-GENE-030131-681
Ensembl - ENSDARG00000076229
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MKL1ENSGALG00000012024Gallus gallus
 MKL1ENSG00000196588Homo sapiens
 Mkl1ENSMUSG00000042292Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
mkl1a / megakaryoblastic leukemia (translocation) 1a / MKL1* / Q8K4J6* / Q969V6* / MKL/myocardin-like protein 1 * / megakaryoblastic leukemia (translocation) 1*ENSDARG0000007586741
mkl2a / MKL/myocardin-like 2a / MKL2* / Q9ULH7* / MKL1/myocardin like 2*ENSDARG0000008830730
mkl2b / MKL/myocardin-like 2b / MKL2* / Q9ULH7* / MKL1/myocardin like 2*ENSDARG0000007686728
si:dkeyp-69b9.3 / MYOCD* / Q8IZQ8* / Q8VIM5* / myocardin*ENSDARG0000008888111


Protein motifs (from Interpro)
Interpro ID Name
 IPR003034  SAP domain
 IPR004018  RPEL repeat
 IPR029992  MKL/myocardin-like protein 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IBA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0010735 positive regulation of transcription via serum response element binding IEA
 biological_processGO:0032515 negative regulation of phosphoprotein phosphatase activity IEA
 biological_processGO:0051145 smooth muscle cell differentiation IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0003713 transcription coactivator activity IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0003785 actin monomer binding IEA
 molecular_functionGO:0004864 protein phosphatase inhibitor activity IEA


Pathways (from Reactome)
Pathway description
SUMOylation of transcription cofactors
RHO GTPases Activate Formins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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