ENSGALG00000012024


Gallus gallus

Features
Gene ID: ENSGALG00000012024
  
Biological name :MKL1
  
Synonyms : megakaryoblastic leukemia (translocation) 1 / MKL1
  
Possible biological names infered from orthology : MKL/myocardin-like protein 1 / Q8K4J6 / Q969V6
  
Species: Gallus gallus
  
Chr. number: 1
Strand: 1
Band:
Gene start: 50007129
Gene end: 50093845
  
Corresponding Affymetrix probe sets: GgaAffx.7629.1.S1_at (Chicken Array)   GgaAffx.7629.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000019596
NCBI entrez gene - 418005     See in Manteia.
RefSeq - XM_004937713
RefSeq - XM_416243
RefSeq - XM_004937714
RefSeq - XM_015288864
swissprot - E1BSL3
Ensembl - ENSGALG00000012024
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mkl1aENSDARG00000075867Danio rerio
 mkl1bENSDARG00000076229Danio rerio
 MKL1ENSG00000196588Homo sapiens
 Mkl1ENSMUSG00000042292Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MKL2 / MKL1/myocardin like 2 / Q9ULH7*ENSGALG0000000302639
MYOCD / myocardin / Q8IZQ8* / Q8VIM5*ENSGALG0000000102130


Protein motifs (from Interpro)
Interpro ID Name
 IPR003034  SAP domain
 IPR004018  RPEL repeat
 IPR029992  MKL/myocardin-like protein 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001764 neuron migration IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IBA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0010735 positive regulation of transcription via serum response element binding IEA
 biological_processGO:0030036 actin cytoskeleton organization IEA
 biological_processGO:0030900 forebrain development IEA
 biological_processGO:0031175 neuron projection development IEA
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0051145 smooth muscle cell differentiation IBA
 biological_processGO:2001234 negative regulation of apoptotic signaling pathway IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0000976 transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003713 transcription coactivator activity IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0003785 actin monomer binding IEA


Pathways (from Reactome)
Pathway description
SUMOylation of transcription cofactors
RHO GTPases Activate Formins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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