ENSDARG00000102798


Danio rerio

Features
Gene ID: ENSDARG00000102798
  
Biological name :mcm2
  
Synonyms : mcm2 / minichromosome maintenance complex component 2
  
Possible biological names infered from orthology : DNA replication licensing factor MCM2 / P49736 / P97310
  
Species: Danio rerio
  
Chr. number: 22
Strand: -1
Band:
Gene start: 5632029
Gene end: 5655680
  
Corresponding Affymetrix probe sets: Dr.2291.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000133012
NCBI entrez gene - 192338     See in Manteia.
swissprot - A0A0R4IF65
ZFIN ID - ZDB-GENE-020419-24
Ensembl - ENSDARG00000102798
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MCM2ENSGALG00000006037Gallus gallus
 MCM2ENSG00000073111Homo sapiens
 Mcm2ENSMUSG00000002870Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001208  MCM domain
 IPR008045  DNA replication licensing factor Mcm2
 IPR012340  Nucleic acid-binding, OB-fold
 IPR018525  Mini-chromosome maintenance, conserved site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR027925  MCM N-terminal domain
 IPR031327  Mini-chromosome maintenance protein
 IPR033762  MCM OB domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006270 DNA replication initiation IEA
 biological_processGO:0032508 DNA duplex unwinding IEA
 biological_processGO:0048538 thymus development IMP
 biological_processGO:0060041 retina development in camera-type eye IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0042555 MCM complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003678 DNA helicase activity IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Activation of ATR in response to replication stress
Assembly of the pre-replicative complex
Orc1 removal from chromatin
Activation of the pre-replicative complex
Switching of origins to a post-replicative state


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain necrotic , abnormal
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 ZFA:0000012 central nervous system central nervous system necrotic , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
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 ZFA:0000112 gut gut hypoplastic , abnormal
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 ZFA:0000123 liver liver hypoplastic , abnormal
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 ZFA:0000152 retina retina quality , abnormal
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 ZFA:0001078 thymus thymus decreased size , abnormal
thymus cell proliferation decreased occurrence , abnormal
thymus epithelial cell decreased amount , abnormal
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 ZFA:0001114 head head decreased size , abnormal
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 ZFA:0001115 trunk trunk undulate , abnormal
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 ZFA:0001613 pharyngeal arch 3-7 pharyngeal arch 3-7 aplastic , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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