ENSMUSG00000002870


Mus musculus

Features
Gene ID: ENSMUSG00000002870
  
Biological name :Mcm2
  
Synonyms : DNA replication licensing factor MCM2 / Mcm2 / P97310
  
Possible biological names infered from orthology : minichromosome maintenance complex component 2 / P49736
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: D1
Gene start: 88883474
Gene end: 88898780
  
Corresponding Affymetrix probe sets: 10546163 (MoGene1.0st)   1434079_s_at (Mouse Genome 430 2.0 Array)   1448777_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000061923
Ensembl peptide - ENSMUSP00000145337
Ensembl peptide - ENSMUSP00000145295
NCBI entrez gene - 17216     See in Manteia.
MGI - MGI:105380
RefSeq - NM_008564
RefSeq Peptide - NP_032590
swissprot - A0A0N4SW20
swissprot - A0A0N4SVY2
swissprot - P97310
Ensembl - ENSMUSG00000002870
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mcm2ENSDARG00000102798Danio rerio
 MCM2ENSGALG00000006037Gallus gallus
 MCM2ENSG00000073111Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001208  MCM domain
 IPR008045  DNA replication licensing factor Mcm2
 IPR012340  Nucleic acid-binding, OB-fold
 IPR018525  Mini-chromosome maintenance, conserved site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR027925  MCM N-terminal domain
 IPR031327  Mini-chromosome maintenance protein
 IPR033762  MCM OB domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006268 DNA unwinding involved in DNA replication IDA
 biological_processGO:0006270 DNA replication initiation TAS
 biological_processGO:0006334 nucleosome assembly IDA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0071353 cellular response to interleukin-4 IDA
 biological_processGO:0090102 cochlea development IEA
 cellular_componentGO:0000785 chromatin IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005664 nuclear origin of replication recognition complex IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0015630 microtubule cytoskeleton IEA
 cellular_componentGO:0042555 MCM complex ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003678 DNA helicase activity IEA
 molecular_functionGO:0003688 DNA replication origin binding IDA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0042393 histone binding IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Activation of ATR in response to replication stress
Assembly of the pre-replicative complex
Orc1 removal from chromatin
Activation of the pre-replicative complex
Switching of origins to a post-replicative state


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000416 sparse fur "fur that is significantly less dense" [J:46854]
Show

Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Xrcc5tm1Dbr/Xrcc5tm1Dbr
Genetic Background: involves: 129S7/SvEvBrd * C57BL

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Xrcc5tm1Dbr/Xrcc5tm1Dbr
Genetic Background: involves: 129S7/SvEvBrd * C57BL

 MP:0000747 muscle weakness "loss of muscle strength" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Xrcc5tm1Dbr/Xrcc5tm1Dbr
Genetic Background: involves: 129S7/SvEvBrd * C57BL

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm4chaos3/Mcm4chaos3
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Xrcc5tm1Dbr/Xrcc5tm1Dbr
Genetic Background: involves: 129S7/SvEvBrd * C57BL

 MP:0001505 hunched posture "stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404]
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Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Xrcc5tm1Dbr/Xrcc5tm1Dbr
Genetic Background: involves: 129S7/SvEvBrd * C57BL

 MP:0001951 abnormal breathing "irregular or atypical breathing pattern " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:17489]
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Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Xrcc5tm1Dbr/Xrcc5tm1Dbr
Genetic Background: involves: 129S7/SvEvBrd * C57BL

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
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Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm4chaos3/Mcm4chaos3
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4chaos3/Mcm4chaos3
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

 MP:0002024 T cell derived lymphoma "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm4chaos3/Mcm4chaos3
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

 MP:0002026 leukemia "progressive proliferation of abnormal leukocytes in hematopoietic tissues, organs and blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm4chaos3/Mcm4chaos3
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

 MP:0002075 abnormal coat color "irregular or unusual pigmentation pattern of the hair in relation to control animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Xrcc5tm1Dbr/Xrcc5tm1Dbr
Genetic Background: involves: 129S7/SvEvBrd * C57BL

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ass1bar/Ass1fold
Genetic Background: involves: C57BL/6Ei * C57BL/6J * OF1 * P/J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Xrcc5tm1Dbr/Xrcc5tm1Dbr
Genetic Background: involves: 129S7/SvEvBrd * C57BL

Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm4chaos3/Mcm4chaos3
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4chaos3/Mcm4chaos3
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cnn2tm1.2Jin/Cnn2tm1.2Jin
Genetic Background: B6.129X1-Cnn2tm1.2Jin

 MP:0002399 abnormal pluripotent precursor cell morphology/development "anomalous structure or fomation of the cells that give rise to most types of cells necessary for fetal development" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm4chaos3/Mcm4chaos3
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4chaos3/Mcm4chaos3
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

 MP:0002447 abnormal erythrocyte morphology "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Xrcc5tm1Dbr/Xrcc5tm1Dbr
Genetic Background: involves: 129S7/SvEvBrd * C57BL

Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm4chaos3/Mcm4chaos3
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4chaos3/Mcm4chaos3
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm4Gt(RRE056)Byg/Mcm4+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4Gt(RRE056)Byg/Mcm4+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm6Gt(YHD248)Byg/Mcm6+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm6Gt(YHD248)Byg/Mcm6+,Mcm7Gt(YTA285)Byg/Mcm7+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm4Gt(RRE056)Byg/Mcm4+,Mcm6Gt(YHD248)Byg/Mcm6+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4Gt(RRE056)Byg/Mcm4+,Mcm6Gt(YHD248)Byg/Mcm6+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4Gt(RRE056)Byg/Mcm4+,Mcm6Gt(YHD248)Byg/Mcm6+,Mcm7Gt(YTA285)Byg/Mcm7+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

 MP:0002640 reticulocytosis "an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm4chaos3/Mcm4chaos3
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
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Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Xrcc5tm1Dbr/Xrcc5tm1Dbr
Genetic Background: involves: 129S7/SvEvBrd * C57BL

 MP:0003111 abnormal nucleus morphology "abnormalities in the nucleus and/or its surrounding membrane" [J:91473, smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Xrcc5tm1Dbr/Xrcc5tm1Dbr
Genetic Background: involves: 129S7/SvEvBrd * C57BL

 MP:0003269 colonic polyps "abnormal tissue masses that protrude into the lumen of the colon and are tethered to the wall of the colon" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Xrcc5tm1Dbr/Xrcc5tm1Dbr
Genetic Background: involves: 129S7/SvEvBrd * C57BL

 MP:0004275 abnormal postnatal subventricular zone morphology "any structural anomaly of the mitotically active layer of cells surrounding the brain ventricles in the adult that consists of migrating neuroblasts, astrocytes and transitory amplifying progenitor cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]
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Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Xrcc5tm1Dbr/Xrcc5tm1Dbr
Genetic Background: involves: 129S7/SvEvBrd * C57BL

 MP:0004841 abnormal small intestine crypts of Lieberkuhn morphology "any structural anomaly in the tubular intestinal glands found in the mucosal membranes of the small intestine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Xrcc5tm1Dbr/Xrcc5tm1Dbr
Genetic Background: involves: 129S7/SvEvBrd * C57BL

 MP:0008011 intestinal polyps "abnormal tissue masses that protrude into the lumen of the intestine and are tethered to the wall of the intestine" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Xrcc5tm1Dbr/Xrcc5tm1Dbr
Genetic Background: involves: 129S7/SvEvBrd * C57BL

 MP:0008108 abnormal small intestinal villus morphology "any structural anomaly of the tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Xrcc5tm1Dbr/Xrcc5tm1Dbr
Genetic Background: involves: 129S7/SvEvBrd * C57BL

 MP:0008866 chromosomal instability "abnormalities of DNA metabolism, DNA repair, cell-cycle governance, or control of apoptosis that increase the probability that whole chromosomes or pieces of chromosomes are gained or lost during cell division, resulting in an imbalance in the number of chromosomes per cell (aneuploidy) and an enhanced rate of loss of heterozygosity" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:12446840]
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Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm4chaos3/Mcm4chaos3
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4chaos3/Mcm4chaos3
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm4Gt(RRE056)Byg/Mcm4+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4Gt(RRE056)Byg/Mcm4+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm6Gt(YHD248)Byg/Mcm6+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm6Gt(YHD248)Byg/Mcm6+,Mcm7Gt(YTA285)Byg/Mcm7+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm4Gt(RRE056)Byg/Mcm4+,Mcm6Gt(YHD248)Byg/Mcm6+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4Gt(RRE056)Byg/Mcm4+,Mcm6Gt(YHD248)Byg/Mcm6+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4Gt(RRE056)Byg/Mcm4+,Mcm6Gt(YHD248)Byg/Mcm6+,Mcm7Gt(YTA285)Byg/Mcm7+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Xrcc5tm1Dbr/Xrcc5tm1Dbr
Genetic Background: involves: 129S7/SvEvBrd * C57BL

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4chaos3/Mcm4chaos3
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
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Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm4chaos3/Mcm4chaos3
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4chaos3/Mcm4chaos3
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

 MP:0014127 increased thymoma incidence "greater than the expected number of a malignant neoplasm originating from the epithelial cells of the thymus, occurring in a specific population in a given time period; thymoma is an uncommon tumor linked with myasthenia gravis and other autoimmune diseases" [http://medical-dictionary.thefreedictionary.com/thymoma, http://www.cancer.gov/cancertopics/pdq/treatment/thymoma/patient/page1#_139]
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Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Xrcc5tm1Dbr/Xrcc5tm1Dbr
Genetic Background: involves: 129S7/SvEvBrd * C57BL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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