ENSDARG00000103025


Danio rerio

Features
Gene ID: ENSDARG00000103025
  
Biological name :hmgcs1
  
Synonyms : 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) / hmgcs1
  
Possible biological names infered from orthology : 3-hydroxy-3-methylglutaryl-CoA synthase 1 / Hydroxymethylglutaryl-CoA synthase, cytoplasmic / Q01581 / Q8JZK9
  
Species: Danio rerio
  
Chr. number: 10
Strand: 1
Band:
Gene start: 6010570
Gene end: 6034397
  
Corresponding Affymetrix probe sets: Dr.2051.1.S1_at (Zebrafish Array)   NM_201085_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000130729
Ensembl peptide - ENSDARP00000145051
Ensembl peptide - ENSDARP00000137373
Ensembl peptide - ENSDARP00000136183
Ensembl peptide - ENSDARP00000135052
NCBI entrez gene - 394060     See in Manteia.
RefSeq - NM_201085
RefSeq - XM_005155491
RefSeq Peptide - NP_957379
swissprot - A0A0J9YJ34
swissprot - A0A0R4IQG1
swissprot - A0A0R4IME3
swissprot - A0A0R4IJE0
ZFIN ID - ZDB-GENE-040426-1042
Ensembl - ENSDARG00000103025
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 HMGCS1ENSGALG00000014862Gallus gallus
 HMGCS1ENSG00000112972Homo sapiens
 Hmgcs1ENSMUSG00000093930Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000590  Hydroxymethylglutaryl-coenzyme A synthase, active site
 IPR010122  Hydroxymethylglutaryl-CoA synthase, eukaryotic
 IPR013528  Hydroxymethylglutaryl-coenzyme A synthase, N-terminal
 IPR013746  Hydroxymethylglutaryl-coenzyme A synthase C-terminal domain
 IPR016039  Thiolase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006694 steroid biosynthetic process IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0008202 steroid metabolic process IEA
 biological_processGO:0008299 isoprenoid biosynthetic process IEA
 biological_processGO:0014003 oligodendrocyte development IMP
 biological_processGO:0016126 sterol biosynthetic process IEA
 cellular_componentGO:0005575 cellular_component ND
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004421 hydroxymethylglutaryl-CoA synthase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Cholesterol biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain apoptotic , abnormal
Show

 ZFA:0000029 hindbrain hindbrain oligodendrocyte poorly differentiated , abnormal
hindbrain oligodendrocyte amount , ameliorated
hindbrain oligodendrocyte decreased amount , abnormal
Show

 ZFA:0000075 spinal cord spinal cord oligodendrocyte dorsal to dorsal longitudinal fasciculus , abnormal
spinal cord oligodendrocyte mislocalised dorsally , abnormal
spinal cord central nervous system myelination occurrence , ameliorated
spinal cord central nervous system myelination decreased occurrence , abnormal
spinal cord has fewer parts of type spinal cord oligodendrocyte, abnormal
spinal cord oligodendrocyte far from dorsal longitudinal fasciculus , abnormal
spinal cord oligodendrocyte amount , ameliorated
spinal cord oligodendrocyte decreased amount , abnormal
spinal cord oligodendrocyte poorly differentiated , abnormal
Show

 ZFA:0000114 heart heart edematous , abnormal
Show

 ZFA:0001106 pharyngeal pouch pharyngeal pouch decreased amount , abnormal
Show

 ZFA:0001194 cranial neural crest cranial neural crest neural crest cell differentiation process quality , abnormal
Show

 ZFA:0001205 Meckel s cartilage Meckels cartilage truncated , abnormal
Meckels cartilage decreased amount , abnormal
Show

 ZFA:0001227 mandibular arch skeleton mandibular arch skeleton decreased size , abnormal
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 ZFA:0001400 ceratohyal cartilage ceratohyal cartilage morphology , abnormal
ceratohyal cartilage decreased amount , abnormal
Show

 ZFA:0001510 basihyal cartilage basihyal cartilage absent , abnormal
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 ZFA:0001516 ceratobranchial cartilage ceratobranchial cartilage malformed , abnormal
ceratobranchial cartilage decreased amount , abnormal
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 ZFA:0005266 dorsal longitudinal fasciculus dorsal longitudinal fasciculus axon ensheathment in central nervous system decreased process quality , abnormal
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 ZFA:0009076 oligodendrocyte oligodendrocyte mislocalised dorsally , abnormal
oligodendrocyte MAPK cascade decreased occurrence , abnormal
oligodendrocyte TOR signaling occurrence , ameliorated
oligodendrocyte TOR signaling decreased occurrence , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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