ENSMUSG00000093930


Mus musculus

Features
Gene ID: ENSMUSG00000093930
  
Biological name :Hmgcs1
  
Synonyms : Hmgcs1 / Hydroxymethylglutaryl-CoA synthase, cytoplasmic / Q8JZK9
  
Possible biological names infered from orthology : 3-hydroxy-3-methylglutaryl-CoA synthase 1 / Q01581
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: D2.3
Gene start: 119690379
Gene end: 119708260
  
Corresponding Affymetrix probe sets: 10412466 (MoGene1.0st)   1433443_a_at (Mouse Genome 430 2.0 Array)   1433444_at (Mouse Genome 430 2.0 Array)   1433445_x_at (Mouse Genome 430 2.0 Array)   1433446_at (Mouse Genome 430 2.0 Array)   1441536_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000136944
Ensembl peptide - ENSMUSP00000153064
Ensembl peptide - ENSMUSP00000153212
NCBI entrez gene - 208715     See in Manteia.
MGI - MGI:107592
RefSeq - XM_006517578
RefSeq - NM_001291439
RefSeq - NM_145942
RefSeq Peptide - NP_001278368
RefSeq Peptide - NP_666054
swissprot - Q8JZK9
swissprot - A0A286YDE3
Ensembl - ENSMUSG00000093930
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hmgcs1ENSDARG00000103025Danio rerio
 HMGCS1ENSGALG00000014862Gallus gallus
 HMGCS1ENSG00000112972Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hmgcs2 / P54869 / Hydroxymethylglutaryl-CoA synthase, mitochondrial / P54868* / 3-hydroxy-3-methylglutaryl-CoA synthase 2*ENSMUSG0000002787559


Protein motifs (from Interpro)
Interpro ID Name
 IPR000590  Hydroxymethylglutaryl-coenzyme A synthase, active site
 IPR010122  Hydroxymethylglutaryl-CoA synthase, eukaryotic
 IPR013528  Hydroxymethylglutaryl-coenzyme A synthase, N-terminal
 IPR013746  Hydroxymethylglutaryl-coenzyme A synthase C-terminal domain
 IPR016039  Thiolase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001889 liver development IEA
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006694 steroid biosynthetic process IEA
 biological_processGO:0006695 cholesterol biosynthetic process IEA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0008202 steroid metabolic process IEA
 biological_processGO:0008203 cholesterol metabolic process IEA
 biological_processGO:0008299 isoprenoid biosynthetic process IEA
 biological_processGO:0008584 male gonad development IEA
 biological_processGO:0009645 response to low light intensity stimulus IEA
 biological_processGO:0009725 response to hormone IEA
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0014074 response to purine-containing compound IEA
 biological_processGO:0016126 sterol biosynthetic process IEA
 biological_processGO:0033197 response to vitamin E IEA
 biological_processGO:0034698 response to gonadotropin IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0046690 response to tellurium ion IEA
 biological_processGO:0070723 response to cholesterol IEA
 biological_processGO:0071372 cellular response to follicle-stimulating hormone stimulus IEA
 biological_processGO:0071397 cellular response to cholesterol IEA
 biological_processGO:0071404 cellular response to low-density lipoprotein particle stimulus IEA
 biological_processGO:0071407 cellular response to organic cyclic compound IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004421 hydroxymethylglutaryl-CoA synthase activity IEA
 molecular_functionGO:0008144 drug binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016853 isomerase activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0043177 organic acid binding IEA


Pathways (from Reactome)
Pathway description
Cholesterol biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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