ENSG00000002726


Homo sapiens

Features
Gene ID: ENSG00000002726
  
Biological name :AOC1
  
Synonyms : amine oxidase, copper containing 1 / AOC1 / P19801
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: 1
Band: q36.1
Gene start: 150824627
Gene end: 150861504
  
Corresponding Affymetrix probe sets: 203559_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000418557
Ensembl peptide - ENSP00000417392
Ensembl peptide - ENSP00000418614
Ensembl peptide - ENSP00000418328
Ensembl peptide - ENSP00000354193
Ensembl peptide - ENSP00000411613
NCBI entrez gene - 26     See in Manteia.
OMIM - 104610
RefSeq - XM_017011945
RefSeq - XM_017011944
RefSeq - NM_001091
RefSeq - NM_001272072
RefSeq - XM_017011947
RefSeq - XM_017011946
RefSeq Peptide - NP_001259001
RefSeq Peptide - NP_001082
swissprot - P19801
swissprot - C9J2J4
swissprot - C9J0G8
Ensembl - ENSG00000002726
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 aoc1ENSDARG00000061355Danio rerio
 ENSGALG00000036190Gallus gallus
 1600015I10RikENSMUSG00000029813Mus musculus
 Aoc1ENSMUSG00000029811Mus musculus
 Doxl2ENSMUSG00000068536Mus musculus
 Svs1ENSMUSG00000039215Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
AOC2 / O75106 / amine oxidase, copper containing 2ENSG0000013148039
AOC3 / Q16853 / amine oxidase, copper containing 3ENSG0000013147138


Protein motifs (from Interpro)
Interpro ID Name
 IPR000269  Copper amine oxidase
 IPR015798  Copper amine oxidase, catalytic domain
 IPR015800  Copper amine oxidase, N2-terminal
 IPR015802  Copper amine oxidase, N3-terminal
 IPR016182  Copper amine oxidase, N-terminal
 IPR036460  Copper amine oxidase, catalytic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006805 xenobiotic metabolic process TAS
 biological_processGO:0009308 amine metabolic process IEA
 biological_processGO:0035874 cellular response to copper ion starvation IDA
 biological_processGO:0042493 response to drug IDA
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0046677 response to antibiotic IDA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0071280 cellular response to copper ion IDA
 biological_processGO:0071420 cellular response to histamine IDA
 biological_processGO:0071504 cellular response to heparin TAS
 biological_processGO:0097185 cellular response to azide IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005777 peroxisome NAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005923 bicellular tight junction ISS
 cellular_componentGO:0035580 specific granule lumen TAS
 cellular_componentGO:0070062 extracellular exosome IDA
 molecular_functionGO:0005507 copper ion binding IEA
 molecular_functionGO:0005509 calcium ion binding IDA
 molecular_functionGO:0008131 primary amine oxidase activity IEA
 molecular_functionGO:0008144 drug binding IDA
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0008270 zinc ion binding IDA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IPI
 molecular_functionGO:0044877 protein-containing complex binding IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0048038 quinone binding IEA
 molecular_functionGO:0052597 diamine oxidase activity IEA
 molecular_functionGO:0052598 histamine oxidase activity TAS
 molecular_functionGO:0052599 methylputrescine oxidase activity IEA
 molecular_functionGO:0052600 propane-1,3-diamine oxidase activity IEA


Pathways (from Reactome)
Pathway description
Phase I - Functionalization of compounds
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000002726 AOC1 / P19801 / amine oxidase, copper containing 1  / complex






 

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