ENSG00000005187


Homo sapiens

Features
Gene ID: ENSG00000005187
  
Biological name :ACSM3
  
Synonyms : ACSM3 / acyl-CoA synthetase medium chain family member 3 / Q53FZ2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: 1
Band: p12.3
Gene start: 20610243
Gene end: 20797581
  
Corresponding Affymetrix probe sets: 205942_s_at (Human Genome U133 Plus 2.0 Array)   210377_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000458068
Ensembl peptide - ENSP00000457608
Ensembl peptide - ENSP00000457926
Ensembl peptide - ENSP00000289416
Ensembl peptide - ENSP00000394565
Ensembl peptide - ENSP00000456055
Ensembl peptide - ENSP00000456767
Ensembl peptide - ENSP00000457003
Ensembl peptide - ENSP00000457158
NCBI entrez gene - 6296     See in Manteia.
OMIM - 145505
RefSeq - XM_017023524
RefSeq - NM_005622
RefSeq - NM_202000
RefSeq - XM_011545911
RefSeq - XM_017023523
RefSeq Peptide - NP_005613
RefSeq Peptide - NP_973729
swissprot - Q53FZ2
swissprot - H3BR33
swissprot - H3BSM0
swissprot - H3BT38
swissprot - H3BTG0
swissprot - H3BV29
swissprot - H3BUF2
swissprot - H3BVD5
Ensembl - ENSG00000005187
  
Related genetic diseases (OMIM): 145505 - {?Hypertension, essential}
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 acsm3ENSDARG00000004880Danio rerio
 ACSM3ENSGALG00000002200Gallus gallus
 Acsm3ENSMUSG00000030935Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ACSM4 / P0C7M7 / acyl-CoA synthetase medium chain family member 4ENSG0000021500959
ACSM5 / Q6NUN0 / acyl-CoA synthetase medium chain family member 5ENSG0000018354958
ACSM2A / Q08AH3 / acyl-CoA synthetase medium chain family member 2AENSG0000018374754
ACSM2B / Q68CK6 / acyl-CoA synthetase medium chain family member 2BENSG0000006681353
ACSM1 / Q08AH1 / acyl-CoA synthetase medium chain family member 1ENSG0000016674352
ACSM6 / Q6P461 / acyl-CoA synthetase medium chain family member 6ENSG0000017312436
ACSS2 / Q9NR19 / acyl-CoA synthetase short chain family member 2ENSG0000013106927
ACSS3 / Q9H6R3 / acyl-CoA synthetase short chain family member 3ENSG0000011105825
ACSS1 / Q9NUB1 / acyl-CoA synthetase short chain family member 1ENSG0000015493025


Protein motifs (from Interpro)
Interpro ID Name
 IPR000873  AMP-dependent synthetase/ligase
 IPR020845  AMP-binding, conserved site
 IPR025110  AMP-binding enzyme, C-terminal domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0006633 fatty acid biosynthetic process IBA
 biological_processGO:0006637 acyl-CoA metabolic process IBA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0008217 regulation of blood pressure TAS
 biological_processGO:0042632 cholesterol homeostasis NAS
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005759 mitochondrial matrix IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0003996 acyl-CoA ligase activity IBA
 molecular_functionGO:0004321 fatty-acyl-CoA synthase activity IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0015645 fatty acid ligase activity IBA
 molecular_functionGO:0016874 ligase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0047760 butyrate-CoA ligase activity IEA


Pathways (from Reactome)
Pathway description
Beta oxidation of butanoyl-CoA to acetyl-CoA


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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