ENSG00000005483


Homo sapiens

Features
Gene ID: ENSG00000005483
  
Biological name :KMT2E
  
Synonyms : KMT2E / lysine methyltransferase 2E / Q8IZD2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: 1
Band: q22.3
Gene start: 105014179
Gene end: 105114361
  
Corresponding Affymetrix probe sets: 223189_x_at (Human Genome U133 Plus 2.0 Array)   223190_s_at (Human Genome U133 Plus 2.0 Array)   226100_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000419525
Ensembl peptide - ENSP00000482147
Ensembl peptide - ENSP00000473963
Ensembl peptide - ENSP00000420415
Ensembl peptide - ENSP00000420206
Ensembl peptide - ENSP00000419883
Ensembl peptide - ENSP00000257745
Ensembl peptide - ENSP00000312379
Ensembl peptide - ENSP00000335398
Ensembl peptide - ENSP00000417156
Ensembl peptide - ENSP00000417193
Ensembl peptide - ENSP00000417888
NCBI entrez gene - 55904     See in Manteia.
OMIM - 608444
RefSeq - XM_017012435
RefSeq - NM_018682
RefSeq - NM_182931
RefSeq - XM_005250493
RefSeq - XM_011516400
RefSeq Peptide - NP_891847
RefSeq Peptide - NP_061152
swissprot - S4R363
swissprot - C9JYI9
swissprot - Q8IZD2
swissprot - C9JNE1
swissprot - A0A087WYW5
swissprot - C9JQ68
swissprot - H7C4F3
swissprot - F8WAU9
swissprot - H7C5C4
Ensembl - ENSG00000005483
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kmt2eENSDARG00000007523Danio rerio
 KMT2EENSGALG00000008167Gallus gallus
 Kmt2eENSMUSG00000029004Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SETD5 / Q9C0A6 / SET domain containing 5ENSG0000016813726


Protein motifs (from Interpro)
Interpro ID Name
 IPR001214  SET domain
 IPR001965  Zinc finger, PHD-type
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR019786  Zinc finger, PHD-type, conserved site
 IPR019787  Zinc finger, PHD-finger


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002446 neutrophil mediated immunity ISS
 biological_processGO:0006306 DNA methylation ISS
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007050 cell cycle arrest IEA
 biological_processGO:0030218 erythrocyte differentiation ISS
 biological_processGO:0034968 histone lysine methylation IEA
 biological_processGO:0042119 neutrophil activation ISS
 biological_processGO:0045652 regulation of megakaryocyte differentiation TAS
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IMP
 biological_processGO:1900087 positive regulation of G1/S transition of mitotic cell cycle IMP
 biological_processGO:1905437 positive regulation of histone H3-K4 trimethylation IMP
 cellular_componentGO:0000785 chromatin IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0035327 transcriptionally active chromatin IDA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0018024 histone-lysine N-methyltransferase activity TAS
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0035064 methylated histone binding IMP
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
PKMTs methylate histone lysines
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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