ENSG00000033170


Homo sapiens

Features
Gene ID: ENSG00000033170
  
Biological name :FUT8
  
Synonyms : fucosyltransferase 8 / FUT8 / Q9BYC5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: 1
Band: q23.3
Gene start: 65410592
Gene end: 65744121
  
Corresponding Affymetrix probe sets: 1554930_a_at (Human Genome U133 Plus 2.0 Array)   203988_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000452597
Ensembl peptide - ENSP00000452309
Ensembl peptide - ENSP00000452433
Ensembl peptide - ENSP00000345865
Ensembl peptide - ENSP00000351057
Ensembl peptide - ENSP00000353910
Ensembl peptide - ENSP00000378087
Ensembl peptide - ENSP00000451577
Ensembl peptide - ENSP00000451689
Ensembl peptide - ENSP00000452105
Ensembl peptide - ENSP00000452147
NCBI entrez gene - 2530     See in Manteia.
OMIM - 602589
RefSeq - XM_017021140
RefSeq - NM_004480
RefSeq - NM_178155
RefSeq - NM_178156
RefSeq - XM_011536614
RefSeq - XM_017021136
RefSeq - XM_017021137
RefSeq - XM_017021138
RefSeq - XM_017021139
RefSeq Peptide - NP_835369
RefSeq Peptide - NP_004471
RefSeq Peptide - NP_835368
swissprot - G3V530
swissprot - G3V5E3
swissprot - G3V5Z4
swissprot - G3XAD2
swissprot - Q546E0
swissprot - G3V443
swissprot - Q9BYC5
swissprot - G3V4A8
swissprot - G3V509
Ensembl - ENSG00000033170
  
Related genetic diseases (OMIM): 618005 - Congenital disorder of glycosylation with defective fucosylation, 618005
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fut8aENSDARG00000015449Danio rerio
 fut8bENSDARG00000088117Danio rerio
 FUT8ENSGALG00000036443Gallus gallus
 Fut8ENSMUSG00000021065Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR015827  Alpha-(1,6)-fucosyltransferase
 IPR027350  Glycosyltransferase family 23 (GT23) domain
 IPR035653  Alpha-(1,6)-fucosyltransferase, SH3 domain
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development NAS
 biological_processGO:0006486 protein glycosylation IEA
 biological_processGO:0006487 protein N-linked glycosylation TAS
 biological_processGO:0006491 N-glycan processing TAS
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0007229 integrin-mediated signaling pathway IEA
 biological_processGO:0007585 respiratory gaseous exchange IEA
 biological_processGO:0009312 oligosaccharide biosynthetic process TAS
 biological_processGO:0010468 regulation of gene expression IEA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0018279 protein N-linked glycosylation via asparagine IDA
 biological_processGO:0033578 protein glycosylation in Golgi IEA
 biological_processGO:0036071 N-glycan fucosylation IEA
 biological_processGO:0042355 L-fucose catabolic process NAS
 biological_processGO:0043112 receptor metabolic process IEA
 biological_processGO:0046368 GDP-L-fucose metabolic process IDA
 biological_processGO:1900407 regulation of cellular response to oxidative stress IEA
 cellular_componentGO:0000139 Golgi membrane TAS
 cellular_componentGO:0005794 Golgi apparatus NAS
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0032580 Golgi cisterna membrane IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008424 glycoprotein 6-alpha-L-fucosyltransferase activity TAS
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016757 transferase activity, transferring glycosyl groups IEA
 molecular_functionGO:0017124 SH3 domain binding IEA
 molecular_functionGO:0046921 alpha-(1->6)-fucosyltransferase activity IEA


Pathways (from Reactome)
Pathway description
Reactions specific to the complex N-glycan synthesis pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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