ENSMUSG00000021065


Mus musculus

Features
Gene ID: ENSMUSG00000021065
  
Biological name :Fut8
  
Synonyms : Alpha-(1,6)-fucosyltransferase / Fut8 / Q9WTS2
  
Possible biological names infered from orthology : fucosyltransferase 8 / Q9BYC5
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: C3
Gene start: 77238125
Gene end: 77476338
  
Corresponding Affymetrix probe sets: 10396712 (MoGene1.0st)   1443656_at (Mouse Genome 430 2.0 Array)   1456367_at (Mouse Genome 430 2.0 Array)   1460319_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000054530
Ensembl peptide - ENSMUSP00000130845
Ensembl peptide - ENSMUSP00000136327
NCBI entrez gene - 53618     See in Manteia.
MGI - MGI:1858901
RefSeq - XM_011244145
RefSeq - NM_001252614
RefSeq - NM_001252615
RefSeq - NM_016893
RefSeq - XM_011244144
RefSeq Peptide - NP_058589
RefSeq Peptide - NP_001239543
RefSeq Peptide - NP_001239544
swissprot - Q9WTS2
Ensembl - ENSMUSG00000021065
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fut8aENSDARG00000015449Danio rerio
 fut8bENSDARG00000088117Danio rerio
 FUT8ENSGALG00000036443Gallus gallus
 FUT8ENSG00000033170Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR015827  Alpha-(1,6)-fucosyltransferase
 IPR027350  Glycosyltransferase family 23 (GT23) domain
 IPR035653  Alpha-(1,6)-fucosyltransferase, SH3 domain
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006486 protein glycosylation IEA
 biological_processGO:0006487 protein N-linked glycosylation IBA
 biological_processGO:0006491 N-glycan processing IMP
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway IMP
 biological_processGO:0007229 integrin-mediated signaling pathway IMP
 biological_processGO:0007585 respiratory gaseous exchange IMP
 biological_processGO:0010468 regulation of gene expression IMP
 biological_processGO:0016477 cell migration IMP
 biological_processGO:0018279 protein N-linked glycosylation via asparagine IEA
 biological_processGO:0033578 protein glycosylation in Golgi IEA
 biological_processGO:0036071 N-glycan fucosylation IMP
 biological_processGO:0043112 receptor metabolic process IMP
 biological_processGO:0046368 GDP-L-fucose metabolic process IEA
 biological_processGO:1900407 regulation of cellular response to oxidative stress IMP
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0032580 Golgi cisterna membrane IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008424 glycoprotein 6-alpha-L-fucosyltransferase activity ISO
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016757 transferase activity, transferring glycosyl groups ISA
 molecular_functionGO:0017124 SH3 domain binding IEA
 molecular_functionGO:0046921 alpha-(1->6)-fucosyltransferase activity IMP


Pathways (from Reactome)
Pathway description
Reactions specific to the complex N-glycan synthesis pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001183 overexpanded alveoli "expanded volume of the saclike terminal dilation of the respiratory bronchioles" [J:66345]
Show

Allelic Composition: Mohg3C57BL/6J/Mohg3CAST/EiJ,Socs2hg/Socs2hg
Genetic Background: involves: C57BL/6J * CAST/EiJ

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mohg3C57BL/6J/Mohg3CAST/EiJ,Socs2hg/Socs2hg
Genetic Background: involves: C57BL/6J * CAST/EiJ

 MP:0001943 abnormal respiration "anomaly in the movement of gases into and out of the lung " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mohg3C57BL/6J/Mohg3CAST/EiJ,Socs2hg/Socs2hg
Genetic Background: involves: C57BL/6J * CAST/EiJ

 MP:0001958 emphysema "lung disease characterized by increased size of terminal bronchioles with destructive changes in their walls and reduction in number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33629]
Show

Allelic Composition: Mohg3C57BL/6J/Mohg3CAST/EiJ,Socs2hg/Socs2hg
Genetic Background: involves: C57BL/6J * CAST/EiJ

 MP:0002338 abnormal pulmonary ventilation "anomaly in the total volume of gas per minute inspired or expired " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mohg3C57BL/6J/Mohg3CAST/EiJ,Socs2hg/Socs2hg
Genetic Background: involves: C57BL/6J * CAST/EiJ

 MP:0003209 abnormal pulmonary elastic fiber morphology "malformation of a slender connective tissue fiber in pulmonary tissue characterized by great elasticity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Mohg3C57BL/6J/Mohg3CAST/EiJ,Socs2hg/Socs2hg
Genetic Background: involves: C57BL/6J * CAST/EiJ

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd44tm1Mak/Cd44tm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010856 dilated respiratory conducting tubes "expansion or widening of the lumens of the tubes of the respiratory system that allow passage of air from the trachea to the alveoli of the lungs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mohg3C57BL/6J/Mohg3CAST/EiJ,Socs2hg/Socs2hg
Genetic Background: involves: C57BL/6J * CAST/EiJ

 MP:0010895 increased lung compliance "increased ability of the lung to distend in response to pressure without disruption, usually expressed as the unit volume of change in the lung per unit of pressure" [ISBN:070202788 "Saunders Comprehensive Veterinary Dictionary, 3rd edition"]
Show

Allelic Composition: Mohg3C57BL/6J/Mohg3CAST/EiJ,Socs2hg/Socs2hg
Genetic Background: involves: C57BL/6J * CAST/EiJ

 MP:0010903 abnormal pulmonary alveolus wall morphology 
Show

Allelic Composition: Cd44tm1Mak/Cd44tm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010908 dilated pulmonary alveolar ducts "expansion or widening of the lumens of the respiratory conducting tubes distal to the respiratory bronchiole that lead to the alveolar sacs and the alveoli" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mohg3C57BL/6J/Mohg3CAST/EiJ,Socs2hg/Socs2hg
Genetic Background: involves: C57BL/6J * CAST/EiJ

 MP:0010937 increased total lung capacity "greater volume of air contained in the lungs at the end of maximal inspiration" [MGI:csmith]
Show

Allelic Composition: Mohg3C57BL/6J/Mohg3CAST/EiJ,Socs2hg/Socs2hg
Genetic Background: involves: C57BL/6J * CAST/EiJ

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Mohg3C57BL/6J/Mohg3CAST/EiJ,Socs2hg/Socs2hg
Genetic Background: involves: C57BL/6J * CAST/EiJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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