ENSG00000053900


Homo sapiens

Features
Gene ID: ENSG00000053900
  
Biological name :ANAPC4
  
Synonyms : ANAPC4 / anaphase promoting complex subunit 4 / Q9UJX5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: 1
Band: p15.2
Gene start: 25377213
Gene end: 25418498
  
Corresponding Affymetrix probe sets: 226917_s_at (Human Genome U133 Plus 2.0 Array)   232524_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000426512
Ensembl peptide - ENSP00000426654
Ensembl peptide - ENSP00000318775
Ensembl peptide - ENSP00000421840
NCBI entrez gene - 29945     See in Manteia.
OMIM - 606947
RefSeq - XM_017008138
RefSeq - NM_001286756
RefSeq - NM_013367
RefSeq - XM_011513838
RefSeq - XM_011513839
RefSeq Peptide - NP_037499
RefSeq Peptide - NP_001273685
swissprot - D6RFM7
swissprot - Q9UJX5
swissprot - D6RAP6
Ensembl - ENSG00000053900
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 anapc4ENSDARG00000032237Danio rerio
 ENSGALG00000040439Gallus gallus
 ENSGALG00000014378Gallus gallus
 Anapc4ENSMUSG00000029176Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017169  Anaphase-promoting complex subunit 4, metazoa
 IPR024789  Anaphase-promoting complex subunit 4
 IPR024790  Anaphase-promoting complex subunit 4 long domain
 IPR024977  Anaphase-promoting complex subunit 4, WD40 domain
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0030071 regulation of mitotic metaphase/anaphase transition IEA
 biological_processGO:0031145 anaphase-promoting complex-dependent catabolic process IEA
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process TAS
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051436 obsolete negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle TAS
 biological_processGO:0051437 obsolete positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition TAS
 biological_processGO:0051439 obsolete regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle TAS
 biological_processGO:0070979 protein K11-linked ubiquitination IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005680 anaphase-promoting complex IEA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0004842 ubiquitin-protein transferase activity TAS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0019903 protein phosphatase binding IPI


Pathways (from Reactome)
Pathway description
Inactivation of APC/C via direct inhibition of the APC/C complex
APC/C:Cdc20 mediated degradation of Cyclin B
Autodegradation of Cdh1 by Cdh1:APC/C
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Phosphorylation of the APC/C
APC-Cdc20 mediated degradation of Nek2A
Separation of Sister Chromatids
Senescence-Associated Secretory Phenotype (SASP)
CDK-mediated phosphorylation and removal of Cdc6
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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