ENSMUSG00000029176


Mus musculus

Features
Gene ID: ENSMUSG00000029176
  
Biological name :Anapc4
  
Synonyms : Anapc4 / Anaphase-promoting complex subunit 4 / Q91W96
  
Possible biological names infered from orthology : Q9UJX5
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: C1
Gene start: 52834012
Gene end: 52867797
  
Corresponding Affymetrix probe sets: 10521863 (MoGene1.0st)   1423930_at (Mouse Genome 430 2.0 Array)   1423931_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000031072
Ensembl peptide - ENSMUSP00000143745
Ensembl peptide - ENSMUSP00000143055
Ensembl peptide - ENSMUSP00000114475
NCBI entrez gene - 52206     See in Manteia.
MGI - MGI:1098673
RefSeq - NM_024213
RefSeq Peptide - NP_077175
swissprot - Q3TM92
swissprot - D6RDT6
swissprot - Q91W96
swissprot - A0A0G2JGY2
swissprot - A0A0G2JF77
Ensembl - ENSMUSG00000029176
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 anapc4ENSDARG00000032237Danio rerio
 ENSGALG00000040439Gallus gallus
 ENSGALG00000014378Gallus gallus
 ANAPC4ENSG00000053900Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017169  Anaphase-promoting complex subunit 4, metazoa
 IPR024789  Anaphase-promoting complex subunit 4
 IPR024790  Anaphase-promoting complex subunit 4 long domain
 IPR024977  Anaphase-promoting complex subunit 4, WD40 domain
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0030071 regulation of mitotic metaphase/anaphase transition IEA
 biological_processGO:0031145 anaphase-promoting complex-dependent catabolic process IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0070979 protein K11-linked ubiquitination IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005680 anaphase-promoting complex IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0019903 protein phosphatase binding IEA


Pathways (from Reactome)
Pathway description
Inactivation of APC/C via direct inhibition of the APC/C complex
APC/C:Cdc20 mediated degradation of Cyclin B
Autodegradation of Cdh1 by Cdh1:APC/C
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Phosphorylation of the APC/C
APC-Cdc20 mediated degradation of Nek2A
Separation of Sister Chromatids
Senescence-Associated Secretory Phenotype (SASP)
CDK-mediated phosphorylation and removal of Cdc6
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001697 abnormal embryo size "anomalous proportions of embryo compared to littermates" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Anapc15tm1.1(KOMP)Vlcg/Anapc15tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Anapc15tm1.1(KOMP)Vlcg/J

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Anapc15tm1.1(KOMP)Vlcg/Anapc15tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Anapc15tm1.1(KOMP)Vlcg/J

 MP:0005632 decreased circulating aspartate transaminase level "less than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Anapc15tm1.1(KOMP)Vlcg/Anapc15tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Anapc15tm1.1(KOMP)Vlcg/J

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Anapc15tm1.1(KOMP)Vlcg/Anapc15tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Anapc15tm1.1(KOMP)Vlcg/J

 MP:0013292 embryonic lethality prior to organogenesis "death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]
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Allelic Composition: Anapc15tm1.1(KOMP)Vlcg/Anapc15tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Anapc15tm1.1(KOMP)Vlcg/J

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
Show

Allelic Composition: Anapc15tm1.1(KOMP)Vlcg/Anapc15tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Anapc15tm1.1(KOMP)Vlcg/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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