ENSG00000057468


Homo sapiens

Features
Gene ID: ENSG00000057468
  
Biological name :MSH4
  
Synonyms : MSH4 / mutS homolog 4 / O15457
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p31.1
Gene start: 75796882
Gene end: 75913238
  
Corresponding Affymetrix probe sets: 210533_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000263187
NCBI entrez gene - 4438     See in Manteia.
OMIM - 602105
RefSeq - NM_002440
RefSeq Peptide - NP_002431
swissprot - O15457
Ensembl - ENSG00000057468
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 msh4ENSDARG00000075826Danio rerio
 MSH4ENSGALG00000011392Gallus gallus
 Msh4ENSMUSG00000005493Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000432  DNA mismatch repair protein MutS, C-terminal
 IPR007696  DNA mismatch repair protein MutS, core
 IPR007860  DNA mismatch repair protein MutS, connector domain
 IPR007861  DNA mismatch repair protein MutS, clamp
 IPR017261  DNA mismatch repair protein MutS/MSH
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR036187  DNA mismatch repair protein MutS, core domain superfamily
 IPR036678  MutS, connector domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001541 ovarian follicle development IEA
 biological_processGO:0006298 mismatch repair IBA
 biological_processGO:0007129 synapsis IEA
 biological_processGO:0007131 reciprocal meiotic recombination TAS
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0007292 female gamete generation IEA
 biological_processGO:0051026 chiasma assembly IBA
 biological_processGO:0051321 meiotic cell cycle IEA
 cellular_componentGO:0000793 condensed chromosome IEA
 cellular_componentGO:0000794 condensed nuclear chromosome IEA
 cellular_componentGO:0000795 synaptonemal complex IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005713 recombination nodule IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003677 DNA binding TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008094 DNA-dependent ATPase activity IBA
 molecular_functionGO:0030983 mismatched DNA binding IBA


Pathways (from Reactome)
Pathway description
Meiotic recombination


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000204410 MSH5 / O43196 / mutS homolog 5  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr