ENSMUSG00000005493


Mus musculus

Features
Gene ID: ENSMUSG00000005493
  
Biological name :Msh4
  
Synonyms : Msh4 / MutS protein homolog 4 / Q99MT2
  
Possible biological names infered from orthology : mutS homolog 4 / O15457
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: H3
Gene start: 153857149
Gene end: 153906138
  
Corresponding Affymetrix probe sets: 10502904 (MoGene1.0st)   1419511_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000005630
Ensembl peptide - ENSMUSP00000140265
Ensembl peptide - ENSMUSP00000140190
NCBI entrez gene - 55993     See in Manteia.
MGI - MGI:1860077
RefSeq - NM_031870
RefSeq - NM_001282054
RefSeq Peptide - NP_001268983
RefSeq Peptide - NP_114076
swissprot - Q99MT2
swissprot - A0A087WQN0
swissprot - A0A087WQG8
swissprot - A6H6D5
Ensembl - ENSMUSG00000005493
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 msh4ENSDARG00000075826Danio rerio
 MSH4ENSGALG00000011392Gallus gallus
 MSH4ENSG00000057468Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000432  DNA mismatch repair protein MutS, C-terminal
 IPR007696  DNA mismatch repair protein MutS, core
 IPR007860  DNA mismatch repair protein MutS, connector domain
 IPR007861  DNA mismatch repair protein MutS, clamp
 IPR011184  DNA mismatch repair Msh2-type
 IPR017261  DNA mismatch repair protein MutS/MSH
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR036187  DNA mismatch repair protein MutS, core domain superfamily
 IPR036678  MutS, connector domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001541 ovarian follicle development IMP
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006298 mismatch repair IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007129 synapsis IMP
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0007292 female gamete generation IMP
 biological_processGO:0051026 chiasma assembly IBA
 biological_processGO:0051321 meiotic cell cycle IMP
 cellular_componentGO:0000793 condensed chromosome IDA
 cellular_componentGO:0000794 condensed nuclear chromosome IDA
 cellular_componentGO:0000795 synaptonemal complex ISS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005713 recombination nodule IDA
 cellular_componentGO:0032301 MutSalpha complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008094 DNA-dependent ATPase activity IBA
 molecular_functionGO:0030983 mismatched DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001127 small ovary "reduced size of the female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Mostm1Sia/Mostm1Sia
Genetic Background: involves: C57BL/6 * CBA

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Mostm1Sia/Mostm1Sia
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Msh4tm1Wed/Msh4tm1Wed,Msh5tm1Rak/Msh5tm1Rak
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Mostm1Sia/Mostm1Sia
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Msh4tm1Wed/Msh4tm1Wed,Msh5tm1Rak/Msh5tm1Rak
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0002209 germ cell depletion "reduced numbers of any of the reproductive (generative) cells of a multicellular organism, whether they are undifferentiated or fully differentiated" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mostm1Sia/Mostm1Sia
Genetic Background: involves: C57BL/6 * CBA

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mostm1Sia/Mostm1Sia
Genetic Background: involves: C57BL/6 * CBA

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mostm1Sia/Mostm1Sia
Genetic Background: involves: C57BL/6 * CBA

 MP:0005168 abnormal female meiosis "malfunction in the process of nuclear division that results in ova with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mostm1Sia/Mostm1Sia
Genetic Background: involves: C57BL/6 * CBA

 MP:0005169 abnormal male meiosis "malfunction in the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mostm1Sia/Mostm1Sia
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Msh4tm1Wed/Msh4tm1Wed,Msh5tm1Rak/Msh5tm1Rak
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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