ENSG00000057657


Homo sapiens

Features
Gene ID: ENSG00000057657
  
Biological name :PRDM1
  
Synonyms : O75626 / PRDM1 / PR/SET domain 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: 1
Band: q21
Gene start: 106086320
Gene end: 106109939
  
Corresponding Affymetrix probe sets: 217192_s_at (Human Genome U133 Plus 2.0 Array)   228964_at (Human Genome U133 Plus 2.0 Array)   235668_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000399772
Ensembl peptide - ENSP00000358087
Ensembl peptide - ENSP00000358092
Ensembl peptide - ENSP00000395566
Ensembl peptide - ENSP00000358085
NCBI entrez gene - 639     See in Manteia.
OMIM - 603423
RefSeq - XM_017011187
RefSeq - NM_001198
RefSeq - NM_182907
RefSeq - XM_006715550
RefSeq - XM_011536062
RefSeq - XM_011536063
RefSeq - XM_011536064
RefSeq Peptide - NP_001189
RefSeq Peptide - NP_878911
swissprot - B2REA5
swissprot - Q5T4E8
swissprot - B2REA4
swissprot - O75626
Ensembl - ENSG00000057657
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prdm1aENSDARG00000002445Danio rerio
 ENSGALG00000015388Gallus gallus
 Prdm1ENSMUSG00000038151Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8IZ20 / ZNF683 / zinc finger protein 683ENSG0000017608320


Protein motifs (from Interpro)
Interpro ID Name
 IPR001214  SET domain
 IPR013087  Zinc finger C2H2-type
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II TAS
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0001763 morphogenesis of a branching structure IEA
 biological_processGO:0001892 embryonic placenta development IEA
 biological_processGO:0001893 maternal placenta development IEA
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0003170 heart valve development IEA
 biological_processGO:0003279 cardiac septum development IEA
 biological_processGO:0003281 ventricular septum development IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007281 germ cell development IEA
 biological_processGO:0009791 post-embryonic development IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0030889 negative regulation of B cell proliferation IEA
 biological_processGO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway IEA
 biological_processGO:0032259 methylation IEA
 biological_processGO:0032823 regulation of natural killer cell differentiation ISS
 biological_processGO:0033082 regulation of extrathymic T cell differentiation ISS
 biological_processGO:0035904 aorta development IEA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0042462 eye photoreceptor cell development IEA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045165 cell fate commitment IEA
 biological_processGO:0045579 positive regulation of B cell differentiation IEA
 biological_processGO:0048844 artery morphogenesis IEA
 biological_processGO:0051136 regulation of NK T cell differentiation ISS
 biological_processGO:0060576 intestinal epithelial cell development IEA
 biological_processGO:0060707 trophoblast giant cell differentiation IEA
 biological_processGO:0060976 coronary vasculature development IEA
 biological_processGO:1990654 sebum secreting cell proliferation IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042826 histone deacetylase binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:1990841 promoter-specific chromatin binding ISS


Pathways (from Reactome)
Pathway description
Regulation of TP53 Expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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