ENSMUSG00000038151


Mus musculus

Features
Gene ID: ENSMUSG00000038151
  
Biological name :Prdm1
  
Synonyms : Prdm1 / PR domain zinc finger protein 1 / Q60636
  
Possible biological names infered from orthology : O75626 / PR/SET domain 1
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: B2
Gene start: 44437177
Gene end: 44528501
  
Corresponding Affymetrix probe sets: 10368970 (MoGene1.0st)   1420425_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000039248
Ensembl peptide - ENSMUSP00000101129
Ensembl peptide - ENSMUSP00000151237
NCBI entrez gene - 12142     See in Manteia.
MGI - MGI:99655
RefSeq - XM_011243109
RefSeq - NM_007548
RefSeq - XM_006512503
RefSeq - XM_006512505
RefSeq - XM_006512502
RefSeq Peptide - NP_031574
swissprot - Q60636
Ensembl - ENSMUSG00000038151
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prdm1aENSDARG00000002445Danio rerio
 ENSGALG00000015388Gallus gallus
 PRDM1ENSG00000057657Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
I7HJS4 / Zfp683 / zinc finger protein 683 / Q8IZ20* / ZNF683*ENSMUSG0000004941018


Protein motifs (from Interpro)
Interpro ID Name
 IPR001214  SET domain
 IPR013087  Zinc finger C2H2-type
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISO
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0001763 morphogenesis of a branching structure IMP
 biological_processGO:0001892 embryonic placenta development IMP
 biological_processGO:0001893 maternal placenta development IMP
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0003170 heart valve development IMP
 biological_processGO:0003279 cardiac septum development IMP
 biological_processGO:0003281 ventricular septum development IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007281 germ cell development IGI
 biological_processGO:0009791 post-embryonic development IMP
 biological_processGO:0010628 positive regulation of gene expression IDA
 biological_processGO:0010629 negative regulation of gene expression IMP
 biological_processGO:0030889 negative regulation of B cell proliferation IDA
 biological_processGO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway IDA
 biological_processGO:0032259 methylation IEA
 biological_processGO:0032823 regulation of natural killer cell differentiation IMP
 biological_processGO:0033082 regulation of extrathymic T cell differentiation IMP
 biological_processGO:0035904 aorta development IMP
 biological_processGO:0042127 regulation of cell proliferation IMP
 biological_processGO:0042462 eye photoreceptor cell development IMP
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045165 cell fate commitment IMP
 biological_processGO:0045579 positive regulation of B cell differentiation IDA
 biological_processGO:0048844 artery morphogenesis IMP
 biological_processGO:0051136 regulation of NK T cell differentiation IMP
 biological_processGO:0060576 intestinal epithelial cell development IMP
 biological_processGO:0060707 trophoblast giant cell differentiation IMP
 biological_processGO:0060976 coronary vasculature development IMP
 biological_processGO:1990654 sebum secreting cell proliferation IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042826 histone deacetylase binding IDA
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:1990841 promoter-specific chromatin binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000284 double outlet right ventricle "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]
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Allelic Composition: Aw-26J/a
Genetic Background: C57BL/6J-Aw-26J/a

 MP:0000565 oligodactyly "congenital condition in which some digits or parts of digits are missing" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Cebpbtm1Nerl/Cebpbtm1Nerl,Tg(KRT14-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
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Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+,Prdm1tm2Masu/Prdm1tm2Masu
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+,Prdm1tm2Masu/Prdm1tm2Masu
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+,Prdm1tm2Masu/Prdm1tm2Masu
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0000737 abnormal myotome development "malformation of or absence of the part of the somite that develops into the musculature" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:29279]
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Allelic Composition: Hsf1tm1Ijb/Hsf1tm1Ijb
Genetic Background: either: (involves: 129S6/SvEvTac * 129X1/SvJ) or (involves: 129S6/SvEvTac * BALB/c) or (involves: 129S6/SvEvTac * C57BL/6J) or (involves: 129S6/SvEvTac * ICR)

Allelic Composition: Prdm1tm2Rob/Prdm1tm2Rob
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cdkn2atm4Rdp/Cdkn2atm4Rdp,Krastm4Tyj/Kras+
Genetic Background: involves: 129S4/SvJae

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Hsf1tm1Ijb/Hsf1tm1Ijb
Genetic Background: either: (involves: 129S6/SvEvTac * 129X1/SvJ) or (involves: 129S6/SvEvTac * BALB/c) or (involves: 129S6/SvEvTac * C57BL/6J) or (involves: 129S6/SvEvTac * ICR)

Allelic Composition: Prdm1tm2Rob/Prdm1tm2Rob
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Prdm1tm1.1Clme/Prdm1tm1.1Clme
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N * ICR

Allelic Composition: Prdm1tm1.1Clme/Prdm1tm2Rob
Genetic Background: involves: 129S/Sv * 129X1/Sv * C57BL/6 * FVB/N * ICR

 MP:0001711 abnormal placenta 
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Allelic Composition: Cdkn2atm4Rdp/Cdkn2atm4Rdp,Krastm4Tyj/Kras+
Genetic Background: involves: 129S4/SvJae

 MP:0001712 abnormal placental development "malformed or incomplete differentiation of the organ of metabolic exchange between the fetus and mother" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
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Allelic Composition: Ccm2ltm1Mlkn/Ccm2ltm1Mlkn,Ccm2tm1Mlkn/Ccm2+,Heg1tm1Mlkn/Heg1tm2.1Mlkn,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0001713 reduced trophoblast cell number "fewer than normal number of cells of the extraembryonic cell layer that contributes to the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:23171]
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Allelic Composition: Ccm2ltm1Mlkn/Ccm2ltm1Mlkn,Ccm2tm1Mlkn/Ccm2+,Heg1tm1Mlkn/Heg1tm2.1Mlkn,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0001716 abnormal placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171]
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Allelic Composition: Hsf1tm1Ijb/Hsf1tm1Ijb
Genetic Background: either: (involves: 129S6/SvEvTac * 129X1/SvJ) or (involves: 129S6/SvEvTac * BALB/c) or (involves: 129S6/SvEvTac * C57BL/6J) or (involves: 129S6/SvEvTac * ICR)

Allelic Composition: Prdm1tm2Rob/Prdm1tm2Rob
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Prdm1tm1.1Clme/Prdm1tm1.1Clme
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N * ICR

Allelic Composition: Prdm1tm1.1Clme/Prdm1tm2Rob
Genetic Background: involves: 129S/Sv * 129X1/Sv * C57BL/6 * FVB/N * ICR

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Muc19tm2Culp/Muc19tm2Culp
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * NFS/NCr

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Prdm1tm1Clme/Prdm1tm1Clme
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Prdm1tm1Clme/Prdm1tm1Clme
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0001859 kidney inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Muc19tm2Culp/Muc19tm2Culp
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * NFS/NCr

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Hsf1tm1Ijb/Hsf1tm1Ijb
Genetic Background: either: (involves: 129S6/SvEvTac * 129X1/SvJ) or (involves: 129S6/SvEvTac * BALB/c) or (involves: 129S6/SvEvTac * C57BL/6J) or (involves: 129S6/SvEvTac * ICR)

Allelic Composition: Prdm1tm2Rob/Prdm1tm2Rob
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Prdm1tm1.1Clme/Prdm1tm1.1Clme
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N * ICR

Allelic Composition: Prdm1tm1.1Clme/Prdm1tm2Rob
Genetic Background: involves: 129S/Sv * 129X1/Sv * C57BL/6 * FVB/N * ICR

 MP:0002023 B cell derived lymphoma "heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gt(ROSA)26Sortm4(Ikbkb)Rsky/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+,Prdm1tm2Masu/Prdm1tm2Masu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+,Prdm1tm2Masu/Prdm1tm2Masu
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm4(Ikbkb)Rsky/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+,Prdm1tm2Masu/Prdm1tm2Masu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+,Prdm1tm2Masu/Prdm1tm2Masu
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Muc19tm2Culp/Muc19tm2Culp
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * NFS/NCr

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Prdm1tm1Clme/Prdm1tm1Clme
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Cebpbtm1Nerl/Cebpbtm1Nerl,Tg(KRT14-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Prdm1tm1.1Clme/Prdm1tm2.1Liz
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ

Allelic Composition: Prdm1tm4.1Liz/Prdm1tm4.1Liz
Genetic Background: involves: 129S/SvEv

 MP:0002208 abnormal germ cell morphology "anomalous structure of the germ cell, that is, any of the reproductive (generative) cells of a multicellular organism, whether they are undifferentiated or fully differentiated" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Cebpbtm1Nerl/Cebpbtm1Nerl,Tg(KRT14-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Atp2b2Obv/Atp2b2Obv
Genetic Background: C3HeB/FeJ-Atp2b2Obv

 MP:0002439 abnormal plasma cell morphology/development "anomalous structure, differentiation, or number of the specialized forms of B-lympocytes which produce and secrete immunoglobulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Prdm1tm1Clme/Prdm1tm1Clme
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0002460 decreased circulating immunoglobulin concentration "less than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Prdm1tm1Clme/Prdm1tm1Clme
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0002461 increased circulating immunoglobulin concentration "greater than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Muc19tm2Culp/Muc19tm2Culp
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * NFS/NCr

 MP:0002493 increased IgG "greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Muc19tm2Culp/Muc19tm2Culp
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * NFS/NCr

 MP:0002747 abnormal aortic valve morphology "malformation of the valve between the left ventricle and the ascending aorta" [J:82728, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Aw-26J/a
Genetic Background: C57BL/6J-Aw-26J/a

 MP:0002884 abnormal branchial arches "malformation or anomaly in the transient structures of the embryo that develop into regions of the head, neck and ears" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hsf1tm1Ijb/Hsf1tm1Ijb
Genetic Background: either: (involves: 129S6/SvEvTac * 129X1/SvJ) or (involves: 129S6/SvEvTac * BALB/c) or (involves: 129S6/SvEvTac * C57BL/6J) or (involves: 129S6/SvEvTac * ICR)

Allelic Composition: Prdm1tm2Rob/Prdm1tm2Rob
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Prdm1tm1.1Clme/Prdm1tm1.1Clme
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N * ICR

Allelic Composition: Prdm1tm1.1Clme/Prdm1tm2Rob
Genetic Background: involves: 129S/Sv * 129X1/Sv * C57BL/6 * FVB/N * ICR

 MP:0002962 increased protein excretion "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]
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Allelic Composition: Muc19tm2Culp/Muc19tm2Culp
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * NFS/NCr

 MP:0002982 abnormal germ cell migration "defects in the orderly movement of a germ cell, a cell specialized to produce haploid gametes, from one site to another during development" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
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Allelic Composition: GckRgsc149/Gck+
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0003725 increased autoantibody level "elevated level of antibodies to self-antigens present in the sera; often indicative of autoimmune disease" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Muc19tm2Culp/Muc19tm2Culp
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * NFS/NCr

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdkn2atm4Rdp/Cdkn2atm4Rdp,Krastm4Tyj/Kras+
Genetic Background: involves: 129S4/SvJae

 MP:0004158 right aortic arch "the aortic arch lies to the right of the trachea and esophagus; results from persistance of the entire right dorsal arch and involution of a segment of the left arch" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Aw-26J/a
Genetic Background: C57BL/6J-Aw-26J/a

 MP:0004206 abnormal dermomyotome development "any structural anomaly of the portion of the embryonic somite that remains after migration of the sclerotomic tissue" [J:50279, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Prdm1tm1.1Clme/Prdm1tm1.1Clme
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N * ICR

Allelic Composition: Prdm1tm1.1Clme/Prdm1tm2Rob
Genetic Background: involves: 129S/Sv * 129X1/Sv * C57BL/6 * FVB/N * ICR

 MP:0004255 abnormal spongiotrophoblast layer morphology "anomaly in the structure of the outer structural layer of the rodent placenta" [PMID:11433360]
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Allelic Composition: Ccm2ltm1Mlkn/Ccm2ltm1Mlkn,Ccm2tm1Mlkn/Ccm2+,Heg1tm1Mlkn/Heg1tm2.1Mlkn,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0004762 increased anti-double stranded DNA antibody level "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Muc19tm2Culp/Muc19tm2Culp
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * NFS/NCr

 MP:0004787 abnormal dorsal aorta morphology "any structural anomaly of the paired arterial structures of the embryo that supplies each developing somite via efferent segmental arteries; the dorsal aortae articulate with the umbilical arteries, which return mixed blood to the villi of the chorion for reoxygenation" [ISBN:0-914294-08-3 "Gray s Anatomy"]
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Allelic Composition: Hsf1tm1Ijb/Hsf1tm1Ijb
Genetic Background: either: (involves: 129S6/SvEvTac * 129X1/SvJ) or (involves: 129S6/SvEvTac * BALB/c) or (involves: 129S6/SvEvTac * C57BL/6J) or (involves: 129S6/SvEvTac * ICR)

Allelic Composition: Prdm1tm2Rob/Prdm1tm2Rob
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Prdm1tm1.1Clme/Prdm1tm1.1Clme
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N * ICR

Allelic Composition: Prdm1tm1.1Clme/Prdm1tm2Rob
Genetic Background: involves: 129S/Sv * 129X1/Sv * C57BL/6 * FVB/N * ICR

 MP:0004794 increased anti-nuclear antigen antibody level "elevated level of antibodies to nuclear antigens present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Muc19tm2Culp/Muc19tm2Culp
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * NFS/NCr

 MP:0004805 absent oocytes "absence of mature germ cells in the female" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Cebpbtm1Nerl/Cebpbtm1Nerl,Tg(KRT14-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Cebpbtm1Nerl/Cebpbtm1Nerl,Tg(KRT14-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0004898 uterine hemorrhage "presence of bleeding in the uterus; often in response to failed pregnancy" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccm2ltm1Mlkn/Ccm2ltm1Mlkn,Ccm2tm1Mlkn/Ccm2+,Heg1tm1Mlkn/Heg1tm2.1Mlkn,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Cebpbtm1Nerl/Cebpbtm1Nerl,Tg(KRT14-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0005327 abnormal mesangial cell "anomalous structure of the phagocytic cell in the capillary tuft of the renal glomerulus, interposed between endothelial cells and the basement membrane in the central or stalk region of the tuft" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:57971]
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Allelic Composition: Muc19tm2Culp/Muc19tm2Culp
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * NFS/NCr

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Muc19tm2Culp/Muc19tm2Culp
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * NFS/NCr

 MP:0006339 abnormal third branchial arch morphology "anomaly in the structure of the third are which contributes to the development of the hyoid bone, stylopharyngeus muscle, inferior parathyroid gland, and thymus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Hsf1tm1Ijb/Hsf1tm1Ijb
Genetic Background: either: (involves: 129S6/SvEvTac * 129X1/SvJ) or (involves: 129S6/SvEvTac * BALB/c) or (involves: 129S6/SvEvTac * C57BL/6J) or (involves: 129S6/SvEvTac * ICR)

Allelic Composition: Prdm1tm2Rob/Prdm1tm2Rob
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0006345 absent second branchial arch "missing the second branchial arch" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Hsf1tm1Ijb/Hsf1tm1Ijb
Genetic Background: either: (involves: 129S6/SvEvTac * 129X1/SvJ) or (involves: 129S6/SvEvTac * BALB/c) or (involves: 129S6/SvEvTac * C57BL/6J) or (involves: 129S6/SvEvTac * ICR)

Allelic Composition: Prdm1tm2Rob/Prdm1tm2Rob
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Prdm1tm1.1Clme/Prdm1tm1.1Clme
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N * ICR

Allelic Composition: Prdm1tm1.1Clme/Prdm1tm2Rob
Genetic Background: involves: 129S/Sv * 129X1/Sv * C57BL/6 * FVB/N * ICR

 MP:0008093 abnormal memory B cell number "anomaly in the number of distinctly differentiated long-lived B cells that are readily activated upon reencounter of an antigenic determinant; memory B cells differentiate from antigen-activated B cells which have been selected for expression of higher affinity immunoglobulin" [CL:0000787, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Prdm1tm1Clme/Prdm1tm1Clme
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0008098 decreased plasma cell number "reduced number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Prdm1tm1Clme/Prdm1tm1Clme
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0008099 abnormal plasma cell differentiation "atypical production of or inability to produce terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Prdm1tm1Clme/Prdm1tm1Clme
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Gt(ROSA)26Sortm4(Ikbkb)Rsky/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+,Prdm1tm2Masu/Prdm1tm2Masu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+,Prdm1tm2Masu/Prdm1tm2Masu
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0008100 absent plasma cells "absence of the terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Cebpbtm1Nerl/Cebpbtm1Nerl,Tg(KRT14-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0008177 increased germinal center B cell number "greater number of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen" [CL:0000844, GO:0002314, ISBN:0781735149]
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Allelic Composition: Muc19tm2Culp/Muc19tm2Culp
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * NFS/NCr

Allelic Composition: Gt(ROSA)26Sortm4(Ikbkb)Rsky/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+,Prdm1tm2Masu/Prdm1tm2Masu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+,Prdm1tm2Masu/Prdm1tm2Masu
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0008192 abnormal germinal center B cell physiology "abnormal function of a rapidly cycling mature B cell which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes" [CL:0000844, GO:0002314, ISBN:0781735149]
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Allelic Composition: Muc19tm2Culp/Muc19tm2Culp
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * NFS/NCr

Allelic Composition: Gt(ROSA)26Sortm4(Ikbkb)Rsky/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+,Prdm1tm2Masu/Prdm1tm2Masu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+,Prdm1tm2Masu/Prdm1tm2Masu
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0008392 decreased primordial germ cell number "reduced number of a mesodermally-derived, most primitive undifferentiated sex cell, that originates in the allantois and migrates through the hindgut and into the gonadal ridge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: GckRgsc149/Gck+
Genetic Background: involves: C57BL/6J * DBA/2J

Allelic Composition: Prdm1tm1Masu/Prdm1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Prdm1tm1Rob/Prdm1tm1Rob
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Prdm1tm1Rob/Prdm1+
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Prdm1tm2Rob/Prdm1tm2Rob
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Prdm1tm2Rob/Prdm1+
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Prdm1tm1.1Clme/Prdm1tm1.1Clme
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N * ICR

Allelic Composition: Prdm1tm1.1Clme/Prdm1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N * ICR

Allelic Composition: Prdm1tm1.1Clme/Prdm1tm1.1Liz
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ

 MP:0008393 absent primordial germ cells "absence of a mesodermally-derived, most primitive undifferentiated sex cell, that originates in the allantois and migrates through the hindgut and into the gonadal ridge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prdm1tm1.1Clme/Prdm1tm2Rob
Genetic Background: involves: 129S/Sv * 129X1/Sv * C57BL/6 * FVB/N * ICR

 MP:0008481 increased spleen germinal center number "greater number of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Prdm1tm1Clme/Prdm1tm1Clme
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Prdm1tm1Clme/Prdm1tm1Clme,Tg(Itgax-cre)1-1Reiz/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0008483 increased spleen germinal center size "greater size of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Prdm1tm1Clme/Prdm1tm1Clme
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm4(Ikbkb)Rsky/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+,Prdm1tm2Masu/Prdm1tm2Masu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+,Prdm1tm2Masu/Prdm1tm2Masu
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0008705 increased interleukin-6 secretion "increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Prdm1tm1Clme/Prdm1tm1Clme,Tg(Itgax-cre)1-1Reiz/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm4(Ikbkb)Rsky/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+,Prdm1tm2Masu/Prdm1tm2Masu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Ighg1tm1(cre)Cgn/Ighg1+,Prdm1tm2Masu/Prdm1tm2Masu
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0008803 abnormal placental labyrinth vasculature morphology "any structural anomaly in blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccm2ltm1Mlkn/Ccm2ltm1Mlkn,Ccm2tm1Mlkn/Ccm2+,Heg1tm1Mlkn/Heg1tm2.1Mlkn,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0009333 abnormal splenocyte physiology "any functional anomaly of a cell of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Cebpbtm1Nerl/Cebpbtm1Nerl,Tg(KRT14-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0009338 increased splenocyte number "increase in the expected number of cells of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prdm1tm1Clme/Prdm1tm1Clme,Tg(Itgax-cre)1-1Reiz/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0010186 increased T follicular helper cell number "greater number of the CD4-positive, CXCR5-positive, CCR7-negative alpha-beta T cells located in follicles of secondary lymph nodes that expresses high levels of BCL-6, ICOS and PD1 and stimulate follicular B cells to undergo class-switching and antibody production" [CL:0002038, PMID:19855402]
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Allelic Composition: Prdm1tm1Clme/Prdm1tm1Clme,Tg(Itgax-cre)1-1Reiz/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0010188 abnormal T follicular helper cell differentiation "atypical production of or inability to produce the CD4-positive, CXCR5-positive, CCR7-negative alpha-beta T cells located in follicles of secondary lymph nodes that expresses high levels of BCL-6, ICOS and PD1 and stimulate follicular B cells to undergo class-switching and antibody production" [CL:0002038, PMID:19855402]
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Allelic Composition: Prdm1tm1Clme/Prdm1tm1Clme,Tg(Itgax-cre)1-1Reiz/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0010412 atrioventricular septal defect "defects in the thin membranous structure between the right atrium and left ventricle that arise from faulty development of the embryonic endocardial cushions; the spectrum ranges from a primum atrial septal defect and cleft mitral valve, known as a partial atrioventricular septal defect (partial AVSD), to defects of both the primum atrial septum and inlet ventricular septum and the presence of a common atrioventricular valve, referred to as complete atrioventricular septal defect (complete AVSD)" [http://emedicine.medscape.com]
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Allelic Composition: Aw-26J/a
Genetic Background: C57BL/6J-Aw-26J/a

 MP:0010466 vascular ring "the trachea and esophagus are completely encircled by connected segments of the aortic arch and its branches" [http://emedicine.medscape.com]
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Allelic Composition: Aw-26J/a
Genetic Background: C57BL/6J-Aw-26J/a

 MP:0010488 abnormal left subclavian artery morphology "any structural anomaly of the artery that extends from the aortic arch to the left side of the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Aw-26J/a
Genetic Background: C57BL/6J-Aw-26J/a

 MP:0010642 absent third branchial arch "absence of the structure of the third are which contributes to the development of the hyoid bone, stylopharyngeus muscle, inferior parathyroid gland, and thymus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Prdm1tm1.1Clme/Prdm1tm1.1Clme
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N * ICR

Allelic Composition: Prdm1tm1.1Clme/Prdm1tm2Rob
Genetic Background: involves: 129S/Sv * 129X1/Sv * C57BL/6 * FVB/N * ICR

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Prdm1tm1.1Clme/Prdm1tm1.1Liz
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Mettm3Kln/Mettm3Kln
Genetic Background: involves: 129/Sv * C57BL/6 * CD-1

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Prdm1tm1Rob/Prdm1tm1Rob
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Prdm1tm2Rob/Prdm1tm2Rob
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Prdm1tm1.1Clme/Prdm1tm1.1Clme
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N * ICR

Allelic Composition: Prdm1tm1.1Clme/Prdm1tm2Rob
Genetic Background: involves: 129S/Sv * 129X1/Sv * C57BL/6 * FVB/N * ICR

Allelic Composition: Prdm1tm3.1Liz/Prdm1tm3.1Liz
Genetic Background: involves: 129S/SvEv

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Prdm1tm1.1Clme/Prdm1tm1.1Liz
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ

 MP:0011262 abnormal branchial arch mesenchyme morphology "any structural anomaly in the primordial embryonic connective tissue associated with the branchial arches, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to facial and cranial nerve-associated structures" [ISBN:0-683-40008-8, MGI:csmith]
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Allelic Composition: Prdm1tm1Rob/Prdm1tm1Rob
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Prdm1tm2Rob/Prdm1tm2Rob
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Prdm1tm1.1Clme/Prdm1tm1.1Clme
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N * ICR

Allelic Composition: Prdm1tm1.1Clme/Prdm1tm2Rob
Genetic Background: involves: 129S/Sv * 129X1/Sv * C57BL/6 * FVB/N * ICR

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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