ENSG00000061337


Homo sapiens

Features
Gene ID: ENSG00000061337
  
Biological name :LZTS1
  
Synonyms : leucine zipper tumor suppressor 1 / LZTS1 / Q9Y250
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: -1
Band: p21.3
Gene start: 20246165
Gene end: 20303963
  
Corresponding Affymetrix probe sets: 1569159_at (Human Genome U133 Plus 2.0 Array)   219042_at (Human Genome U133 Plus 2.0 Array)   221719_s_at (Human Genome U133 Plus 2.0 Array)   221721_s_at (Human Genome U133 Plus 2.0 Array)   221722_x_at (Human Genome U133 Plus 2.0 Array)   222107_x_at (Human Genome U133 Plus 2.0 Array)   47550_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000265801
Ensembl peptide - ENSP00000370981
Ensembl peptide - ENSP00000429263
Ensembl peptide - ENSP00000479534
NCBI entrez gene - 11178     See in Manteia.
OMIM - 606551
RefSeq - XM_011544386
RefSeq - NM_021020
RefSeq - XM_011544384
RefSeq - XM_011544385
RefSeq - XM_005273394
RefSeq - XM_011544383
RefSeq Peptide - NP_066300
swissprot - Q9Y250
Ensembl - ENSG00000061337
  
Related genetic diseases (OMIM): 133239 - Esophageal squamous cell carcinoma, 133239
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lzts1ENSDARG00000075565Danio rerio
 LZTS1ENSGALG00000001727Gallus gallus
 Lzts1ENSMUSG00000036306Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
LZTS2 / Q9BRK4 / leucine zipper tumor suppressor 2ENSG0000010781641
LZTS3 / O60299 / leucine zipper tumor suppressor family member 3ENSG0000008889931
N4BP3 / O15049 / NEDD4 binding protein 3ENSG0000014591123


Protein motifs (from Interpro)
Interpro ID Name
 IPR033293  Leucine zipper putative tumour suppressor 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated NAS
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0016242 negative regulation of macroautophagy IMP
 biological_processGO:0044772 mitotic cell cycle phase transition IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 molecular_functionGO:0003677 DNA binding NAS
 molecular_functionGO:0003700 DNA-binding transcription factor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008017 microtubule binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000006 Autosomal dominant inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele." [HPO:curators]
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 HP:0002860 Squamous cell carcinoma 
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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