ENSMUSG00000036306


Mus musculus

Features
Gene ID: ENSMUSG00000036306
  
Biological name :Lzts1
  
Synonyms : leucine zipper, putative tumor suppressor 1 / Lzts1 / P60853
  
Possible biological names infered from orthology : leucine zipper tumor suppressor 1 / Q9Y250
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: B3.3
Gene start: 69132669
Gene end: 69184225
  
Corresponding Affymetrix probe sets: 10579043 (MoGene1.0st)   1433988_s_at (Mouse Genome 430 2.0 Array)   1440103_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000039397
Ensembl peptide - ENSMUSP00000139117
NCBI entrez gene - 211134     See in Manteia.
MGI - MGI:2684762
RefSeq - XM_006509608
RefSeq - NM_199364
RefSeq - XM_006509606
RefSeq - XM_006509607
RefSeq Peptide - NP_955396
swissprot - P60853
Ensembl - ENSMUSG00000036306
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lzts1ENSDARG00000075565Danio rerio
 LZTS1ENSGALG00000001727Gallus gallus
 LZTS1ENSG00000061337Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lzts2 / Q91YU6 / Leucine zipper putative tumor suppressor 2 / Q9BRK4* / leucine zipper tumor suppressor 2*ENSMUSG0000003534239
Lzts3 / A2AHG0 / Leucine zipper putative tumor suppressor 3 / O60299* / leucine zipper tumor suppressor family member 3*ENSMUSG0000003770333
N4bp3 / Q8C7U1 / NEDD4-binding protein 3 / O15049*ENSMUSG0000000105325


Protein motifs (from Interpro)
Interpro ID Name
 IPR033293  Leucine zipper putative tumour suppressor 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0016242 negative regulation of macroautophagy ISO
 biological_processGO:0044772 mitotic cell cycle phase transition IEA
 biological_processGO:0048167 regulation of synaptic plasticity IEA
 biological_processGO:0048814 regulation of dendrite morphogenesis IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0043198 dendritic shaft IEA
 cellular_componentGO:0044297 cell body IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 molecular_functionGO:0008017 microtubule binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
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Allelic Composition: E2f4tm1Lees/E2f4+,E2f5tm1Dli/E2f5tm1Dli
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6

 MP:0001458 abnormal object recognition memory "defects in the ability to recognize objects that the animal has previously encountered; recognition is measured by relative amount of time exploring objects, which should decrease upon subsequent or multiple presentations of the same object when presented with novel objects at the same time" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: E2f4tm1Lees/E2f4+,E2f5tm1Dli/E2f5tm1Dli
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
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Allelic Composition: Brca1tm1Aash/Brca1tm1Aash,Tg(LGB-cre)74Acl/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Lzts1tm1Cro/Lzts1tm1Cro
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Lzts1tm1Kso/Lzts1tm1Kso
Genetic Background: B6J.B6NTac-Lzts1tm1Kso

 MP:0002027 lung adenocarcinoma "malignant neoplasm of epithelial cells in the lung" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Lzts1tm1Cro/Lzts1tm1Cro
Genetic Background: involves: 129 * C57BL/6J

 MP:0002032 sarcoma "connective tissue neoplasm associated with the proliferation of mesodermal cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: Lzts1tm1Cro/Lzts1tm1Cro
Genetic Background: involves: 129 * C57BL/6J

 MP:0002038 carcinoma "malignant neoplasm arising from epithelial cells, usually glandular or squamous" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: Brca1tm1Aash/Brca1tm1Aash,Tg(LGB-cre)74Acl/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Lzts1tm1Cro/Lzts1tm1Cro
Genetic Background: involves: 129 * C57BL/6J

 MP:0002048 lung adenoma "benign epithelial neoplasm of the lung" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:57631]
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Allelic Composition: Brca1tm1Aash/Brca1tm1Aash,Tg(LGB-cre)74Acl/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Lzts1tm1Kso/Lzts1tm1Kso
Genetic Background: B6J.B6NTac-Lzts1tm1Kso

 MP:0002886 abnormal glutamate receptor currents "change in the measured amplitude or duration of response to stimulation of glutmanergic receptors" [Principles of Neural Science, 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Lzts1tm1Kso/Lzts1tm1Kso
Genetic Background: B6J.B6NTac-Lzts1tm1Kso

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
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Allelic Composition: Lzts1tm1Cro/Lzts1tm1Cro
Genetic Background: involves: 129 * C57BL/6J

 MP:0003331 hepatocellular carcinoma "malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Brca1tm1Aash/Brca1tm1Aash,Tg(LGB-cre)74Acl/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Lzts1tm1Cro/Lzts1tm1Cro
Genetic Background: involves: 129 * C57BL/6J

 MP:0004753 abnormal miniature excitatory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Lzts1tm1Kso/Lzts1tm1Kso
Genetic Background: B6J.B6NTac-Lzts1tm1Kso

 MP:0004996 abnormal CNS synapse formation "any anomaly in the process of generating the initial connections between an axon and effector tissue or neuron" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lzts1tm1Kso/Lzts1tm1Kso
Genetic Background: B6J.B6NTac-Lzts1tm1Kso

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Lzts1tm1Cro/Lzts1tm1Cro
Genetic Background: involves: 129 * C57BL/6J

 MP:0008010 gastric adenocarcinoma "malignant neoplasm of epithelial cells in the stomach" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Brca1tm1Aash/Brca1tm1Aash,Tg(LGB-cre)74Acl/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Lzts1tm1Cro/Lzts1tm1Cro
Genetic Background: involves: 129 * C57BL/6J

 MP:0008428 abnormal spatial working memory "anomaly in the ability to spontaneously process spatial location information in order to naviagate or perform other behavior using such locational cues, without previous encounters or training at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lzts1tm1Kso/Lzts1tm1Kso
Genetic Background: B6J.B6NTac-Lzts1tm1Kso

 MP:0009936 abnormal dendritic spine morphology "any structural anomaly of the small membranous protrusion from the dendrite of a neuron that is involved in synaptic transmission; it typically receives input from a single synapse of an axon" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Lzts1tm1Kso/Lzts1tm1Kso
Genetic Background: B6J.B6NTac-Lzts1tm1Kso

 MP:0010299 increased mammary gland tumor incidence "greater than the expected number of neoplasms in the mammary gland, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Brca1tm1Aash/Brca1tm1Aash,Tg(LGB-cre)74Acl/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Lzts1tm1Cro/Lzts1tm1Cro
Genetic Background: involves: 129 * C57BL/6J

 MP:0010301 increased stomach tumor incidence "greater than the expected number of neoplasms in the gastric tissue usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Brca1tm1Aash/Brca1tm1Aash,Tg(LGB-cre)74Acl/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Lzts1tm1Cro/Lzts1tm1Cro
Genetic Background: involves: 129 * C57BL/6J

 MP:0011273 prolonged excitatory postsynaptic current decay time 
Show

Allelic Composition: Lzts1tm1Kso/Lzts1tm1Kso
Genetic Background: B6J.B6NTac-Lzts1tm1Kso

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
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Allelic Composition: Lzts1tm1Cro/Lzts1tm1Cro
Genetic Background: involves: 129 * C57BL/6J

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
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Allelic Composition: Brca1tm1Aash/Brca1tm1Aash,Tg(LGB-cre)74Acl/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Lzts1tm1Cro/Lzts1tm1Cro
Genetic Background: involves: 129 * C57BL/6J

 MP:0013501 increased fibroblast apoptosis "increase in the timing or the number of fibroblast cells undergoing programmed cell death" [MGI:csmith]
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Allelic Composition: Lzts1tm1Cro/Lzts1tm1Cro
Genetic Background: involves: 129 * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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