ENSMUSG00000035342


Mus musculus

Features
Gene ID: ENSMUSG00000035342
  
Biological name :Lzts2
  
Synonyms : Leucine zipper putative tumor suppressor 2 / Lzts2 / Q91YU6
  
Possible biological names infered from orthology : leucine zipper tumor suppressor 2 / Q9BRK4
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: C3
Gene start: 45015176
Gene end: 45027104
  
Corresponding Affymetrix probe sets: 10463457 (MoGene1.0st)   1426409_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000045478
Ensembl peptide - ENSMUSP00000136405
Ensembl peptide - ENSMUSP00000137571
NCBI entrez gene - 226154     See in Manteia.
MGI - MGI:2385095
RefSeq - XM_006527005
RefSeq - NM_001130525
RefSeq - NM_001130526
RefSeq - NM_145503
RefSeq - XM_006527004
RefSeq Peptide - NP_663478
RefSeq Peptide - NP_001123997
RefSeq Peptide - NP_001123998
swissprot - Q91YU6
Ensembl - ENSMUSG00000035342
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lzts2aENSDARG00000074597Danio rerio
 lzts2bENSDARG00000077207Danio rerio
 LZTS2ENSGALG00000023612Gallus gallus
 LZTS2ENSG00000107816Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lzts1 / P60853 / leucine zipper, putative tumor suppressor 1 / Q9Y250* / leucine zipper tumor suppressor 1*ENSMUSG0000003630635
Lzts3 / A2AHG0 / Leucine zipper putative tumor suppressor 3 / O60299* / leucine zipper tumor suppressor family member 3*ENSMUSG0000003770334
N4bp3 / Q8C7U1 / NEDD4-binding protein 3 / O15049*ENSMUSG0000000105323


Protein motifs (from Interpro)
Interpro ID Name
 IPR028597  Leucine zipper putative tumour suppressor 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001822 kidney development IMP
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0016055 Wnt signaling pathway IGI
 biological_processGO:0030178 negative regulation of Wnt signaling pathway IMP
 biological_processGO:0051301 cell division IEA
 biological_processGO:0072001 renal system development IMP
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IGI
 biological_processGO:1900181 negative regulation of protein localization to nucleus IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0031982 vesicle ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000516 abnormal urinary system morphology "structural or developmental anomaly of any of the organs involved in the production or excretion of urine " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Crbntm1.2Jjh/Crbntm1.2Jjh
Genetic Background: involves: C57BL/6

 MP:0000519 hydronephrosis "dilation of the pelvis and calices of one or both kidneys" [J:56641]
Show

Allelic Composition: Crbntm1.2Jjh/Crbntm1.2Jjh
Genetic Background: involves: C57BL/6

 MP:0000534 abnormal ureter morphology "anomalous structure of the tube that conducts the urine from the renal pelvis to the bladder" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Crbntm1.2Jjh/Crbntm1.2Jjh
Genetic Background: involves: C57BL/6

 MP:0000536 hydroureter "distention of the ureter with urine, due to blockage from any cause" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:Cml, J:13044]
Show

Allelic Composition: Crbntm1.2Jjh/Crbntm1.2Jjh
Genetic Background: involves: C57BL/6

 MP:0002059 abnormal seminal gland morphology "anomalous structure of one of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Crbntm1.2Jjh/Crbntm1.2Jjh
Genetic Background: involves: C57BL/6

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Crbntm1.2Jjh/Crbntm1.2Jjh
Genetic Background: involves: C57BL/6

 MP:0002705 dilated renal tubules "enlarged lumens of the loops of Henle and/or collecting ducts of the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Crbntm1.2Jjh/Crbntm1.2Jjh
Genetic Background: involves: C57BL/6

 MP:0002990 short ureter "reduced length of the tube that conducts the urine from the renal pelvis to the bladder" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Crbntm1.2Jjh/Crbntm1.2Jjh
Genetic Background: involves: C57BL/6

 MP:0003586 ureter dilation "abnormal distention of the ureter due to accumulation of fluid" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Crbntm1.2Jjh/Crbntm1.2Jjh
Genetic Background: involves: C57BL/6

 MP:0003675 kidney cysts "abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Crbntm1.2Jjh/Crbntm1.2Jjh
Genetic Background: involves: C57BL/6

 MP:0003827 abnormal Wolffian duct morphology "malformation of the transient embryonic tubes that empty into the cloca and degenerate in the male " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Crbntm1.2Jjh/Crbntm1.2Jjh
Genetic Background: involves: C57BL/6

 MP:0003942 abnormal urinary system development 
Show

Allelic Composition: Crbntm1.2Jjh/Crbntm1.2Jjh
Genetic Background: involves: C57BL/6

 MP:0004017 duplex kidney "a kidney that is split into two separate collecting systems; there may be a duplex ureter or a single ureter; may present unilaterally or bilaterally" [rbabiuk:Randall Babiuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Crbntm1.2Jjh/Crbntm1.2Jjh
Genetic Background: involves: C57BL/6

 MP:0004967 abnormal kidney epithelium morphology "any structural anomaly of the cellular avascular layer of the kidney luminar surfaces" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Crbntm1.2Jjh/Crbntm1.2Jjh
Genetic Background: involves: C57BL/6

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Crbntm1.2Jjh/Crbntm1.2Jjh
Genetic Background: involves: C57BL/6

 MP:0009085 abnormal uterine horn morphology "any structural anomaly of either one of the pair of tubular extensions from the uterine body where the uterus and the uterine tubes meet; uterine horns are anterior Mullerian duct-derived structures" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Crbntm1.2Jjh/Crbntm1.2Jjh
Genetic Background: involves: C57BL/6

 MP:0010980 ectopic ureteric bud "ureteric bud(s) are not located in the normal or expected position" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Crbntm1.2Jjh/Crbntm1.2Jjh
Genetic Background: involves: C57BL/6

 MP:0011493 double ureter "two ureters open separately into the renal pelvis superiorly and drain separately into the urinary bladder or genital tract; if two ureteral buds arise from the Wolffian duct, a duplex kidney with complete ureteral duplication ensues" [http://emedicine.medscape.com/article/378075-overview, MGI:anna]
Show

Allelic Composition: Crbntm1.2Jjh/Crbntm1.2Jjh
Genetic Background: involves: C57BL/6

 MP:0011803 double kidney pelvis "duplication of the funnel shaped proximal portion of the ureter that is formed by convergence of the major calices" [MGI:anna]
Show

Allelic Composition: Crbntm1.2Jjh/Crbntm1.2Jjh
Genetic Background: involves: C57BL/6

 MP:0013320 dilated seminal vesicles "an expansion in the lumen volume of either of the paired sac-like glandular structures situated posterolateral to the urinary bladder in the male and functioning as part of the reproductive system, as by stretching or distention" [MGI:Anna]
Show

Allelic Composition: Crbntm1.2Jjh/Crbntm1.2Jjh
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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