ENSG00000063177


Homo sapiens

Features
Gene ID: ENSG00000063177
  
Biological name :RPL18
  
Synonyms : Q07020 / ribosomal protein L18 / RPL18
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: q13.33
Gene start: 48615328
Gene end: 48619536
  
Corresponding Affymetrix probe sets: 200022_at (Human Genome U133 Plus 2.0 Array)   214335_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000449067
Ensembl peptide - ENSP00000449204
Ensembl peptide - ENSP00000470988
Ensembl peptide - ENSP00000449610
Ensembl peptide - ENSP00000084795
Ensembl peptide - ENSP00000446634
Ensembl peptide - ENSP00000447001
Ensembl peptide - ENSP00000447894
Ensembl peptide - ENSP00000448899
NCBI entrez gene - 6141     See in Manteia.
OMIM - 604179
RefSeq - NM_001270490
RefSeq - NM_000979
RefSeq Peptide - NP_000970
RefSeq Peptide - NP_001257419
swissprot - F8VYV2
swissprot - G3V203
swissprot - H0YHA7
swissprot - J3QQ67
swissprot - A0A075B7A0
swissprot - Q07020
swissprot - A0A024QZD1
swissprot - F8VUA6
swissprot - F8VXR6
Ensembl - ENSG00000063177
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rpl18ENSDARG00000029533Danio rerio
 Rpl18ENSMUSG00000059070Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000039  Ribosomal protein L18e
 IPR021131  Ribosomal protein L18e/L15P
 IPR021132  Ribosomal protein L18e, conserved site
 IPR036227  Ribosomal L18e/L15P superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
 biological_processGO:0002181 cytoplasmic translation IDA
 biological_processGO:0006364 rRNA processing TAS
 biological_processGO:0006412 translation IEA
 biological_processGO:0006413 translational initiation TAS
 biological_processGO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS
 biological_processGO:0019083 viral transcription TAS
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus HDA
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005791 rough endoplasmic reticulum IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005840 ribosome IEA
 cellular_componentGO:0005925 focal adhesion HDA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0022625 cytosolic large ribosomal subunit TAS
 cellular_componentGO:0042788 polysomal ribosome IDA
 molecular_functionGO:0003723 RNA binding TAS
 molecular_functionGO:0003735 structural constituent of ribosome IEA


Pathways (from Reactome)
Pathway description
L13a-mediated translational silencing of Ceruloplasmin expression
Peptide chain elongation
SRP-dependent cotranslational protein targeting to membrane
Viral mRNA Translation
Selenocysteine synthesis
Major pathway of rRNA processing in the nucleolus and cytosol
Formation of a pool of free 40S subunits
GTP hydrolysis and joining of the 60S ribosomal subunit
Eukaryotic Translation Termination
Regulation of expression of SLITs and ROBOs
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000078 Abnormality of the genital tract 
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 HP:0000079 Abnormality of the urinary tract 
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 HP:0000175 Cleft palate "Cleft palate is a developmental defect of the `palate` (FMA:54549) resulting from a failure of fusion of the palatine processes." [HPO:curators]
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 HP:0000179 Prominent lower lip "Increased thickness of the lower lip, leading to a prominent appearance of the lower lip." [HPO:curators]
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 HP:0000457 Flat nose 
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 HP:0000823 Delayed puberty 
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 HP:0000980 Pallor 
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 HP:0001155 Abnormality of the hand "An abnormality affecting one or both hands." [HPO:curators]
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 HP:0001972 Macrocytic anemia 
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 HP:0002076 Migraine 
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 HP:0002488 Acute leukemia 
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 HP:0003196 Nasal hypoplasia "Underdevelopment of the `nose` (FMA:46472)." [HPO:probinson]
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 HP:0004322 Decreased body height "A height below that which is expected according to age and gender norms. Although there is no universally accepted definition of short stature, many refer to "short stature" as height more than 2 standard deviations below the mean for age and gender (or below the 3rd percentile for age and gender dependent norms)." [HPO:curators]
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 HP:0011675 Arrhythmia "Any cardiac rhythm other than the normal sinus rhythm. Such a rhythm may be either of sinus or ectopic origin and either regular or irregular. An arrhythmia may be due to a disturbance in impulse formation or conduction or both." [DDD:dbrown, pmid:19063792]
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 HP:0012378 Fatigue "A subjective feeling of tiredness characterized by a lack of energy and motivation." [HPO:probinson]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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