ENSG00000064666


Homo sapiens

Features
Gene ID: ENSG00000064666
  
Biological name :CNN2
  
Synonyms : calponin 2 / CNN2 / Q99439
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: p13.3
Gene start: 1026581
Gene end: 1039068
  
Corresponding Affymetrix probe sets: 201605_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000457968
Ensembl peptide - ENSP00000484749
Ensembl peptide - ENSP00000484533
Ensembl peptide - ENSP00000479188
Ensembl peptide - ENSP00000475175
Ensembl peptide - ENSP00000468577
Ensembl peptide - ENSP00000458137
Ensembl peptide - ENSP00000263097
Ensembl peptide - ENSP00000340129
Ensembl peptide - ENSP00000455777
Ensembl peptide - ENSP00000456436
NCBI entrez gene - 1265     See in Manteia.
OMIM - 602373
RefSeq - NM_004368
RefSeq - NM_201277
RefSeq - NM_001303501
RefSeq - NM_001303499
RefSeq Peptide - NP_004359
RefSeq Peptide - NP_958434
RefSeq Peptide - NP_001290428
RefSeq Peptide - NP_001290430
swissprot - B4DUT8
swissprot - U3KPS3
swissprot - B4DDF4
swissprot - A0A087X271
swissprot - A0A087X1X5
swissprot - A0A087WV51
swissprot - H3BQH0
swissprot - H3BVI6
swissprot - K7ES69
swissprot - Q99439
Ensembl - ENSG00000064666
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cnn2ENSDARG00000035858Danio rerio
 CNN2ENSGALG00000027777Gallus gallus
 Cnn2ENSMUSG00000004665Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CNN3 / Q15417 / calponin 3ENSG0000011751961
CNN1 / P51911 / calponin 1ENSG0000013017656
P37802 / TAGLN2 / transgelin 2ENSG0000015871025
Q9UI15 / TAGLN3 / transgelin 3ENSG0000014483425
TAGLN / Q01995 / transgelinENSG0000014959123


Protein motifs (from Interpro)
Interpro ID Name
 IPR000557  Calponin repeat
 IPR001715  Calponin homology domain
 IPR001997  Calponin/LIMCH1
 IPR003096  Smooth muscle protein/calponin
 IPR029974  Calponin-2
 IPR036872  CH domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007010 cytoskeleton organization IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0030097 hemopoiesis IEA
 biological_processGO:0030336 negative regulation of cell migration IEA
 biological_processGO:0031032 actomyosin structure organization IEA
 biological_processGO:0032970 regulation of actin filament-based process IDA
 biological_processGO:0035722 interleukin-12-mediated signaling pathway TAS
 biological_processGO:0042060 wound healing IEA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0050765 negative regulation of phagocytosis IEA
 biological_processGO:0071260 cellular response to mechanical stimulus IDA
 cellular_componentGO:0001725 stress fiber IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005911 cell-cell junction TAS
 cellular_componentGO:0005925 focal adhesion HDA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0035580 specific granule lumen TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:1904724 tertiary granule lumen TAS
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0045296 cadherin binding IDA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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