ENSMUSG00000004665


Mus musculus

Features
Gene ID: ENSMUSG00000004665
  
Biological name :Cnn2
  
Synonyms : Calponin-2 / Cnn2 / Q08093
  
Possible biological names infered from orthology : Q99439
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: C1
Gene start: 79988584
Gene end: 79996062
  
Corresponding Affymetrix probe sets: 10364593 (MoGene1.0st)   1450981_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000101013
Ensembl peptide - ENSMUSP00000004784
NCBI entrez gene - 12798     See in Manteia.
MGI - MGI:105093
RefSeq - NM_007725
RefSeq Peptide - NP_031751
swissprot - D3Z7R6
swissprot - Q08093
swissprot - Q543F3
Ensembl - ENSMUSG00000004665
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cnn2ENSDARG00000035858Danio rerio
 CNN2ENSGALG00000027777Gallus gallus
 CNN2ENSG00000064666Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cnn3 / Q9DAW9 / Calponin-3 / Q15417*ENSMUSG0000005393164
Cnn1 / Q08091 / Calponin-1 / P51911*ENSMUSG0000000134960
Q9WVA4 / Tagln2 / Transgelin-2 / P37802*ENSMUSG0000002654728
Q9R1Q8 / Tagln3 / Transgelin-3 / Q9UI15*ENSMUSG0000002265827
Tagln / P37804 / Transgelin / Q01995*ENSMUSG0000003208526


Protein motifs (from Interpro)
Interpro ID Name
 IPR000557  Calponin repeat
 IPR001715  Calponin homology domain
 IPR001997  Calponin/LIMCH1
 IPR003096  Smooth muscle protein/calponin
 IPR029974  Calponin-2
 IPR036872  CH domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007010 cytoskeleton organization IEA
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0030097 hemopoiesis IMP
 biological_processGO:0030336 negative regulation of cell migration IMP
 biological_processGO:0031032 actomyosin structure organization IEA
 biological_processGO:0032970 regulation of actin filament-based process ISO
 biological_processGO:0042060 wound healing IMP
 biological_processGO:0042127 regulation of cell proliferation IMP
 biological_processGO:0050765 negative regulation of phagocytosis IMP
 biological_processGO:0071260 cellular response to mechanical stimulus ISO
 cellular_componentGO:0001725 stress fiber ISO
 cellular_componentGO:0005856 cytoskeleton IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0045296 cadherin binding ISO


Pathways (from Reactome)
Pathway description
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Spag6ltm1Jfs/Spag6l+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Cnn2tm1.2Jin/Cnn2tm1.2Jin
Genetic Background: B6.129X1-Cnn2tm1.2Jin

 MP:0000223 decreased monocyte count "fewer than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Spag6ltm1Jfs/Spag6l+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Cnn2tm1.2Jin/Cnn2tm1.2Jin
Genetic Background: B6.129X1-Cnn2tm1.2Jin

 MP:0000321 increased bone marrow cell number "increased number of cells that make up the core cavitites of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Spag6ltm1Jfs/Spag6l+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0000334 decreased granulocyte number "fewer than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Spag6ltm1Jfs/Spag6l+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0000716 abnormal immune system cell morphology "anomalous structure, development, or number of immune cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Spag6ltm1Jfs/Spag6l+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Spag6ltm1Jfs/Spag6l+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0002724 enhanced wound healing "increased ability to self-repair and close wounds" [dlb:Donna Burkart , Mouse Genome Informatics Curator, J:42016]
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Allelic Composition: Cnn2tm1.2Jin/Cnn2tm1.2Jin
Genetic Background: B6.129X1-Cnn2tm1.2Jin

 MP:0005425 increased macrophage count "greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418]
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Allelic Composition: Cnn2tm1.2Jin/Cnn2tm1.2Jin
Genetic Background: B6.129X1-Cnn2tm1.2Jin

 MP:0010760 abnormal macrophage chemotaxis "anomaly in the movement of a macrophage guided by a specific chemical concentration gradient" [GO:0048246]
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Allelic Composition: Cnn2tm1.2Jin/Cnn2tm1.2Jin
Genetic Background: B6.129X1-Cnn2tm1.2Jin

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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