ENSMUSG00000001349


Mus musculus

Features
Gene ID: ENSMUSG00000001349
  
Biological name :Cnn1
  
Synonyms : Calponin-1 / Cnn1 / Q08091
  
Possible biological names infered from orthology : P51911
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: A3
Gene start: 22099216
Gene end: 22109630
  
Corresponding Affymetrix probe sets: 10583809 (MoGene1.0st)   1417917_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000001384
Ensembl peptide - ENSMUSP00000150665
Ensembl peptide - ENSMUSP00000149628
Ensembl peptide - ENSMUSP00000149514
NCBI entrez gene - 12797     See in Manteia.
MGI - MGI:104979
RefSeq - XM_011242388
RefSeq - NM_009922
RefSeq - XM_006509969
RefSeq Peptide - NP_034052
swissprot - A0A1L1SUB2
swissprot - B2RSH3
swissprot - Q08091
swissprot - A0A1L1SRV0
swissprot - A0A1L1SRL1
Ensembl - ENSMUSG00000001349
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cnn1aENSDARG00000017193Danio rerio
 cnn1bENSDARG00000102398Danio rerio
 CNN1ENSG00000130176Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cnn3 / Q9DAW9 / Calponin-3 / Q15417*ENSMUSG0000005393169
Cnn2 / Q08093 / Calponin-2 / Q99439*ENSMUSG0000000466561
Q9R1Q8 / Tagln3 / Transgelin-3 / Q9UI15*ENSMUSG0000002265829
Q9WVA4 / Tagln2 / Transgelin-2 / P37802*ENSMUSG0000002654728
Tagln / P37804 / Transgelin / Q01995*ENSMUSG0000003208527


Protein motifs (from Interpro)
Interpro ID Name
 IPR000557  Calponin repeat
 IPR001715  Calponin homology domain
 IPR001997  Calponin/LIMCH1
 IPR003096  Smooth muscle protein/calponin
 IPR036872  CH domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0031032 actomyosin structure organization IEA
 biological_processGO:1904706 negative regulation of vascular smooth muscle cell proliferation ISO
 cellular_componentGO:0005856 cytoskeleton ISO
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005516 calmodulin binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000164 abnormal cartilage development "anomalous formation of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lipetm1Gam/Lipetm1Gam
Genetic Background: involves: 129S4/SvJae

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Lipetm1Gam/Lipetm1Gam
Genetic Background: involves: 129S4/SvJae

 MP:0002999 abnormal bone healing "defects in the restoration of integrity to bone after trauma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lipetm1Gam/Lipetm1Gam
Genetic Background: involves: 129S4/SvJae

 MP:0003416 premature bone ossification "early onset of the formation of bone" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Lipetm1Gam/Lipetm1Gam
Genetic Background: involves: 129S4/SvJae

 MP:0004988 increased osteoblast cell number "greater than average number of the bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lipetm1Gam/Lipetm1Gam
Genetic Background: involves: 129S4/SvJae

 MP:0008151 increased diameter of long bones "increased width of the cross-sectional distance that extends from one lateral edge of a long bone, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lipetm1Gam/Lipetm1Gam
Genetic Background: involves: 129S4/SvJae

 MP:0008158 increased diameter of femur "increased width of the cross-sectional distance that extends from one lateral edge of the femur, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lipetm1Gam/Lipetm1Gam
Genetic Background: involves: 129S4/SvJae

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * BALB/cJ * C57BL/6

 MP:0011710 increased osteoblast differentiation 
Show

Allelic Composition: Lipetm1Gam/Lipetm1Gam
Genetic Background: involves: 129S4/SvJae

 MP:0014167 ectopic bone "the appearance of an extra bone structure at an atypical location" [MGI:csmith]
Show

Allelic Composition: Lipetm1Gam/Lipetm1Gam
Genetic Background: involves: 129S4/SvJae

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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