Manteia - Molecule gene

ENSMUSG00000032085

Mus musculus

Features

Gene ID:	ENSMUSG00000032085

Biological name :	Tagln

Synonyms :	P37804 / Tagln / Transgelin

Possible biological names infered from orthology :	Q01995

Species:	Mus musculus

Chr. number:	9
Strand:	-1
Band:	A5.2
Gene start:	45929619
Gene end:	45936058

Corresponding Affymetrix probe sets:	10593123 (MoGene1.0st) 1423505_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000150408 Ensembl peptide - ENSMUSP00000034590 NCBI entrez gene - 21345 See in Manteia. MGI - MGI:106012 RefSeq - NM_011526 RefSeq Peptide - NP_035656 swissprot - A0A1L1STN8 swissprot - P37804 Ensembl - ENSMUSG00000032085

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
tagln	ENSDARG00000045408	Danio rerio
tagln2	ENSDARG00000033466	Danio rerio
TAGLN	ENSGALG00000011902	Gallus gallus
TAGLN	ENSG00000149591	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Q9WVA4 / Tagln2 / Transgelin-2 / P37802*	ENSMUSG00000026547	67
Q9R1Q8 / Tagln3 / Transgelin-3 / Q9UI15*	ENSMUSG00000022658	66
Cnn3 / Q9DAW9 / Calponin-3 / Q15417*	ENSMUSG00000053931	42
Cnn1 / Q08091 / Calponin-1 / P51911*	ENSMUSG00000001349	40
Cnn2 / Q08093 / Calponin-2 / Q99439*	ENSMUSG00000004665	39

Protein motifs (from Interpro)

Interpro ID	Name
IPR000557	Calponin repeat
IPR001715	Calponin homology domain
IPR003096	Smooth muscle protein/calponin
IPR029976	Transgelin
IPR036872	CH domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0030855	epithelial cell differentiation	IEA
cellular_component	GO:0005737	cytoplasm	IEA
molecular_function	GO:0005515	protein binding	IEA
molecular_function	GO:0051015	actin filament binding	IEA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000477	abnormal intestine morphology	"malformation of the digestive tube passing from the stomach to the anus" [J:48968]	Show Allelic Composition: Mylk^tm1Mzhu/Mylk^tm1Mzhu,Tagln^{tm1(cre/ERT2)Feil}/? Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6
MP:0001270	distended abdomen	"abdomen appears curved outward or swollen; can be due to skeletal axial defects, enlarged visceral organs or megacolon" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Plin2^tm1Itl/Plin2^tm1Itl,Rpe65^tm1Tmr/Rpe65^tm1Tmr,Tyr^c-2J/Tyr^c-2J Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * BALB/c * C57BL/6
MP:0001663	abnormal digestive system physiology	"altered function of the organ system that converts ingested food to nutrients and energy" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Plin2^tm1Itl/Plin2^tm1Itl,Rpe65^tm1Tmr/Rpe65^tm1Tmr,Tyr^c-2J/Tyr^c-2J Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * BALB/c * C57BL/6
MP:0001915	intracranial hemorrhage	"bleeding within the skull, including hemorrhage into the brain and within the cranial epidural, subdural, and subarachnoid spaces" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Ccm2^tm1Etl/Ccm2^tm1Etl Genetic Background: involves: 129
MP:0001923	reduced female fertility	"reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]	Show Allelic Composition: Prkg1^tm2.1Naw/Prkg1^tm2.1Naw,Tagln^{tm1(PRKG1)Hfm}/Tagln⁺ Genetic Background:* involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Prkg1^tm2.1Naw/Prkg1^tm2.1Naw,Tagln^{tm2(PRKG1)Hfm}/Tagln⁺ Genetic Background:* involves: 129S1/Sv * 129X1/SvJ
MP:0001935	reduced litter size	"fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Prkg1^tm2.1Naw/Prkg1^tm2.1Naw,Tagln^{tm1(PRKG1)Hfm}/Tagln⁺ Genetic Background:* involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Prkg1^tm2.1Naw/Prkg1^tm2.1Naw,Tagln^{tm2(PRKG1)Hfm}/Tagln⁺ Genetic Background:* involves: 129S1/Sv * 129X1/SvJ
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Prkg1^tm2.1Naw/Prkg1^tm2.1Naw,Tagln^{tm1(PRKG1)Hfm}/Tagln⁺ Genetic Background:* involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Prkg1^tm2.1Naw/Prkg1^tm2.1Naw,Tagln^{tm2(PRKG1)Hfm}/Tagln⁺ Genetic Background:* involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Stk11^tm1.1Rdp/Stk11⁺,Tagln^{tm1(cre/ERT2)Feil}/Tagln⁺ Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL Allelic Composition: Mylk^tm1Mzhu/Mylk^tm1Mzhu,Tagln^{tm1(cre/ERT2)Feil}/? Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Pax6^Sey/Pax6^Sey Genetic Background: involves: Swiss Allelic Composition: Tagln^tm2(cre)Yec/Tagln^tm2(cre)Yec Genetic Background: involves: 129S6/SvEvTac * C57BL/6 Allelic Composition: Tagln^tm1Liw/Tagln^tm1Liw Genetic Background: involves: 129/Sv * C57BL/6
MP:0002191	abnormal artery morphology	"malformation of the blood vessels that carry blood away from the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ccm2^tm1Etl/Ccm2^tm1Etl Genetic Background: involves: 129
MP:0002843	decreased blood pressure	"decreased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Mylk^tm1Mzhu/Mylk^tm1Mzhu,Tagln^{tm1(cre/ERT2)Feil}/? Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6
MP:0003157	impaired muscle relaxation	"reduced or absent ability of muscle to lengthen following contractions" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92510]	Show Allelic Composition: Mrvi1^tm2.1Jens/Mrvi1^tm2.1Jens Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0003270	intestinal obstruction	"any impediment, blockage, or reversal of the normal flow of the intestinal contents toward the anus " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Stk11^tm1.1Rdp/Stk11⁺,Tagln^{tm1(cre/ERT2)Feil}/Tagln⁺ Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL
MP:0003289	abnormal intestinal peristalsis	"altered intestinal movement characterized by waves of alternate circular contraction and relaxation of the muscular walls of the bowel that move bowel contents forward" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Mylk^tm1Mzhu/Mylk^tm1Mzhu,Tagln^{tm1(cre/ERT2)Feil}/? Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6
MP:0003306	small intestinal inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the small intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Mylk^tm1Mzhu/Mylk^tm1Mzhu,Tagln^{tm1(cre/ERT2)Feil}/? Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6
MP:0003622	incomplete emptying of bladder	"upon urination, some urine is retained in the bladder instead of being excreted" [ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Mylk^tm1Mzhu/Mylk^tm1Mzhu,Tagln^{tm1(cre/ERT2)Feil}/? Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6
MP:0003814	vascular smooth muscle cell hypoplasia	"decreased numbers of smooth muscle cells in the vascular wall" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ccm2^tm1Etl/Ccm2^tm1Etl Genetic Background: involves: 129 Allelic Composition: Msx1^tm1Rem/Msx1^tm1Rem,Msx2^tm1Yvla/Msx2^tm1Yvla,Tagln^tm2(cre)Yec/Tagln⁺ Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * NMRI
MP:0003866	abnormal defecation	"anomaly in the production and excretion of feces" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Mylk^tm1Mzhu/Mylk^tm1Mzhu,Tagln^{tm1(cre/ERT2)Feil}/? Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6
MP:0004111	abnormal coronary artery morphology	"anomaly of any of the arteries that branch from the aorta to supply blood to the heart" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Tbx18^tm1.1Mwmy/Tbx18^tm1.1Mwmy Genetic Background: involves: 129 * C57BL/6J
MP:0004181	abnormal carotid artery morphology	"malformation of any of the four arteries (two on each side of the neck; right and left internal carotid arteries, and right and left external carotid arteries) that deliver oxygen-rich blood from the heart to the head and brain" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Ccm2^tm1Etl/Ccm2^tm1Etl Genetic Background: involves: 129 Allelic Composition: Msx1^tm1Rem/Msx1^tm1Rem,Msx2^tm1Yvla/Msx2^tm1Yvla,Tagln^tm2(cre)Yec/Tagln⁺ Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * NMRI
MP:0004703	abnormal vertebral column	"any structural anomaly of the complete structure forming the rostral-caudal axis of the skeleton formed from the alternating segments of vertebra and intervertebral discs which support the spinal cord" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Mylk^tm1Mzhu/Mylk^tm1Mzhu,Tagln^{tm1(cre/ERT2)Feil}/? Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6
MP:0005341	decreased susceptibility to atherosclerosis	"less likely than the norm to develop thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ptch1^tm1Yy/Ptch1⁺,Trp53^tm1Brd/Trp53⁺,Tg(BGLAP-cre)1Clem/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/NJ
MP:0005592	abnormal vascular smooth muscle morphology	"structural anomaly of the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Tbx18^tm1.1Mwmy/Tbx18^tm1.1Mwmy Genetic Background: involves: 129 * C57BL/6J
MP:0006263	decreased diastolic blood pressure	"abnormal decrease in the pressure in the arteries between heart beats when the heart is relaxed" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:21887]	Show Allelic Composition: Mylk^tm1Mzhu/Mylk^tm1Mzhu,Tagln^{tm1(cre/ERT2)Feil}/? Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6
MP:0006264	decreased systolic blood pressure	"abnormal decrease in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:21887]	Show Allelic Composition: Mylk^tm1Mzhu/Mylk^tm1Mzhu,Tagln^{tm1(cre/ERT2)Feil}/? Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6
MP:0008802	abnormal intestinal smooth muscle morphology	"any structural anomaly of the nonstriated, involuntary muscle tissue lining the intestine" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Mylk^tm1Mzhu/Mylk^tm1Mzhu,Tagln^{tm1(cre/ERT2)Feil}/? Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6
MP:0009485	distended ileum	"an expansion in the volume of the portion of the small intestine that extends from the jejunum to the colon, as by stretching or distention" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Mylk^tm1Mzhu/Mylk^tm1Mzhu,Tagln^{tm1(cre/ERT2)Feil}/? Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6
MP:0010279	increased gastrointestinal tumor incidence	"greater than the expected number of tumors originating in the gastrointestinal system in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Stk11^tm1.1Rdp/Stk11⁺,Tagln^{tm1(cre/ERT2)Feil}/Tagln⁺ Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL Allelic Composition: Stk11^tm1.1Rdp/Stk11^tm1.1Rdp,Tagln^{tm1(cre/ERT2)Feil}/Tagln⁺ Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL
MP:0010352	gastrointestinal tract polyps	"abnormal tissue masses that protrude into the lumen of the gastrointestinal tract and are tethered to the wall of the gastrointestinal tract" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Stk11^tm1.1Rdp/Stk11⁺,Tagln^{tm1(cre/ERT2)Feil}/Tagln⁺ Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL Allelic Composition: Stk11^tm1.1Rdp/Stk11^tm1.1Rdp,Tagln^{tm1(cre/ERT2)Feil}/Tagln⁺ Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL
MP:0010386	abnormal urinary bladder physiology	"any functional anomaly of the distensible musculomembranous organ that serves to collect and store urine excreted by the kidneys" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Mylk^tm1Mzhu/Mylk^tm1Mzhu,Tagln^{tm1(cre/ERT2)Feil}/? Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6
MP:0010478	intracranial aneurysm	"a protruding sac within the cranial space formed by the dilation of the wall of an artery or a vein resulting from a weakening of the vessel wall" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ccm2^tm1Etl/Ccm2^tm1Etl Genetic Background: involves: 129
MP:0010551	abnormal coronary vessel morphology	"any structural anomaly of any of the arteries or veins that supply blood to the heart or return blood from the heart muscles to the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tagln^tm1Liw/Tagln⁺,Tbx18^tm1.1Mwmy/Tbx18^tm1.1Mwmy Genetic Background: involves: 129 * C57BL/6J
MP:0011082	abnormal gastrointestinal motility	"anomaly in the propulsive movements of the digestive system, resulting in the transit of the contents along the gastrointestinal tract" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Mylk^tm1Mzhu/Mylk^tm1Mzhu,Tagln^{tm1(cre/ERT2)Feil}/? Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6
MP:0011503	disdended jejunum	"an expansion in the volume of the portion of the small intestine that extends from the duodenum to the ileum" [MGI:anna]	Show Allelic Composition: Mylk^tm1Mzhu/Mylk^tm1Mzhu,Tagln^{tm1(cre/ERT2)Feil}/? Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6
MP:0011513	abnormal vertebral artery morphology	"any structural anomaly of the first branch of the left and right subclavian arteries that merge to form the single midline basilar artery; branches of the vertebral arteries supply the musculature of the neck" [ISBN:0-683-40008-8]	Show Allelic Composition: Ccm2^tm1Etl/Ccm2^tm1Etl Genetic Background: involves: 129
MP:0011940	decreased food intake	"reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]	Show Allelic Composition: Mylk^tm1Mzhu/Mylk^tm1Mzhu,Tagln^{tm1(cre/ERT2)Feil}/? Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

External programs and data are copyrighted by and are the property of their respective authors. The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation
		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr