ENSG00000067225


Homo sapiens

Features
Gene ID: ENSG00000067225
  
Biological name :PKM
  
Synonyms : P14618 / PKM / pyruvate kinase M1/2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: -1
Band: q23
Gene start: 72199029
Gene end: 72231822
  
Corresponding Affymetrix probe sets: 201251_at (Human Genome U133 Plus 2.0 Array)   209446_s_at (Human Genome U133 Plus 2.0 Array)   213700_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000457253
Ensembl peptide - ENSP00000457830
Ensembl peptide - ENSP00000457198
Ensembl peptide - ENSP00000457420
Ensembl peptide - ENSP00000320171
Ensembl peptide - ENSP00000334983
Ensembl peptide - ENSP00000373745
Ensembl peptide - ENSP00000403365
Ensembl peptide - ENSP00000454668
Ensembl peptide - ENSP00000455584
Ensembl peptide - ENSP00000455736
Ensembl peptide - ENSP00000455901
Ensembl peptide - ENSP00000456004
Ensembl peptide - ENSP00000456100
Ensembl peptide - ENSP00000456970
Ensembl peptide - ENSP00000456984
NCBI entrez gene - 5315     See in Manteia.
OMIM - 179050
RefSeq - NM_001206797
RefSeq - XM_017022313
RefSeq - XM_011521670
RefSeq - XM_006720570
RefSeq - XM_005254445
RefSeq - XM_005254443
RefSeq - NM_182471
RefSeq - NM_182470
RefSeq - NM_002654
RefSeq - NM_001316318
RefSeq - NM_001206799
RefSeq - NM_001206796
RefSeq - NM_001206798
RefSeq Peptide - NP_001193727
RefSeq Peptide - NP_001193725
RefSeq Peptide - NP_001193726
RefSeq Peptide - NP_001193728
RefSeq Peptide - NP_001303247
RefSeq Peptide - NP_002645
RefSeq Peptide - NP_872270
RefSeq Peptide - NP_872271
swissprot - H3BR70
swissprot - H3BQZ3
swissprot - H3BQ34
swissprot - H3BN34
swissprot - B4DNK4
swissprot - A0A024R5Z9
swissprot - H3BUW1
swissprot - H3BU13
swissprot - H3BTN5
swissprot - H3BTJ2
swissprot - H3BT25
swissprot - P14618
swissprot - V9HWB8
Ensembl - ENSG00000067225
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pkmaENSDARG00000099730Danio rerio
 pkmbENSDARG00000099860Danio rerio
 PKMENSGALG00000001992Gallus gallus
 PkmENSMUSG00000032294Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PKLR / P30613 / pyruvate kinase L/RENSG0000014362769


Protein motifs (from Interpro)
Interpro ID Name
 IPR001697  Pyruvate kinase
 IPR011037  Pyruvate kinase-like, insert domain superfamily
 IPR015793  Pyruvate kinase, barrel
 IPR015795  Pyruvate kinase, C-terminal
 IPR015813  Pyruvate/Phosphoenolpyruvate kinase-like domain superfamily
 IPR018209  Pyruvate kinase, active site
 IPR036918  Pyruvate kinase, C-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0001889 liver development IEA
 biological_processGO:0006006 glucose metabolic process IEA
 biological_processGO:0006096 glycolytic process IEA
 biological_processGO:0006754 ATP biosynthetic process IEA
 biological_processGO:0007584 response to nutrient IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0009629 response to gravity IEA
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0012501 programmed cell death IDA
 biological_processGO:0014870 response to muscle inactivity IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0031100 animal organ regeneration IEA
 biological_processGO:0032868 response to insulin IEA
 biological_processGO:0032869 cellular response to insulin stimulus IBA
 biological_processGO:0042866 pyruvate biosynthetic process IEA
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0043403 skeletal muscle tissue regeneration IEA
 biological_processGO:0051289 protein homotetramerization IEA
 biological_processGO:0061621 canonical glycolysis TAS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005929 cilium IEA
 cellular_componentGO:0031012 extracellular matrix HDA
 cellular_componentGO:0031982 vesicle HDA
 cellular_componentGO:0034774 secretory granule lumen TAS
 cellular_componentGO:0043209 myelin sheath IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:1902912 pyruvate kinase complex IEA
 cellular_componentGO:1903561 extracellular vesicle HDA
 cellular_componentGO:1904813 ficolin-1-rich granule lumen TAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004743 pyruvate kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0023026 MHC class II protein complex binding HDA
 molecular_functionGO:0030955 potassium ion binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0043531 ADP binding IEA
 molecular_functionGO:0045296 cadherin binding IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070324 thyroid hormone binding IEA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000067225 PKM / P14618 / pyruvate kinase M1/2  / complex






 

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