ENSMUSG00000032294


Mus musculus

Features
Gene ID: ENSMUSG00000032294
  
Biological name :Pkm
  
Synonyms : P52480 / Pkm / Pyruvate kinase PKM
  
Possible biological names infered from orthology : P14618 / pyruvate kinase M1/2
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: B
Gene start: 59656368
Gene end: 59679375
  
Corresponding Affymetrix probe sets: 10585932 (MoGene1.0st)   1417308_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000128770
Ensembl peptide - ENSMUSP00000151199
Ensembl peptide - ENSMUSP00000150901
Ensembl peptide - ENSMUSP00000150578
Ensembl peptide - ENSMUSP00000150509
Ensembl peptide - ENSMUSP00000150188
Ensembl peptide - ENSMUSP00000149983
Ensembl peptide - ENSMUSP00000149206
Ensembl peptide - ENSMUSP00000034834
NCBI entrez gene - 18746     See in Manteia.
MGI - MGI:97591
RefSeq - XM_011242674
RefSeq - NM_001253883
RefSeq - NM_011099
RefSeq - XM_006510855
RefSeq - XM_006510856
RefSeq - XM_011242673
RefSeq Peptide - NP_035229
RefSeq Peptide - NP_001240812
swissprot - A0A1L1SVH2
swissprot - A0A1L1SU37
swissprot - A0A1L1STV8
swissprot - A0A1L1ST52
swissprot - A0A1L1SSN6
swissprot - A0A1L1SUV0
swissprot - A0A1L1SQV8
swissprot - P52480
Ensembl - ENSMUSG00000032294
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pkmaENSDARG00000099730Danio rerio
 pkmbENSDARG00000099860Danio rerio
 PKMENSGALG00000001992Gallus gallus
 PKMENSG00000067225Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pklr / pyruvate kinase L/R / P30613*ENSMUSG0000004123769


Protein motifs (from Interpro)
Interpro ID Name
 IPR001697  Pyruvate kinase
 IPR011037  Pyruvate kinase-like, insert domain superfamily
 IPR015793  Pyruvate kinase, barrel
 IPR015795  Pyruvate kinase, C-terminal
 IPR015813  Pyruvate/Phosphoenolpyruvate kinase-like domain superfamily
 IPR018209  Pyruvate kinase, active site
 IPR036918  Pyruvate kinase, C-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006096 glycolytic process IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0012501 programmed cell death ISO
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0032869 cellular response to insulin stimulus IBA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005929 cilium IDA
 cellular_componentGO:0031012 extracellular matrix HDA
 cellular_componentGO:0043209 myelin sheath IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004743 pyruvate kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0030955 potassium ion binding IEA
 molecular_functionGO:0045296 cadherin binding ISO
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation
Glycolysis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001272 increased metastatic potential 
Show

Allelic Composition: Brca1tm2Cxd/Brca1tm2Cxd,Pkmtm1.1Mgvh/Pkmtm1.1Mgvh,Tg(MMTV-cre)4Mam/0,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * 129S7/SvEvBrd * FVB/N

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1(Wls/YFP)Mbtr/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1(Wls/YFP)Mbtr/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6

 MP:0008019 liver tumor "presence of abnormal, rapidly proliferating cells in the liver usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Brca1tm2Cxd/Brca1tm2Cxd,Pkmtm1.1Mgvh/Pkmtm1.1Mgvh,Tg(MMTV-cre)4Mam/0,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * 129S7/SvEvBrd * FVB/N

 MP:0010299 increased mammary gland tumor incidence "greater than the expected number of neoplasms in the mammary gland, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Brca1tm2Cxd/Brca1tm2Cxd,Pkmtm1.1Mgvh/Pkmtm1.1Mgvh,Tg(MMTV-cre)4Mam/0,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * 129S7/SvEvBrd * FVB/N

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Nr3c1tm2.1Gsc/Nr3c1tm2.1Gsc
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0011093 complete embryonic lethality at implantation "death of all organisms of a given genotype in a population at the point of implantation (Mus: E4.5)" [MGI:csmith]
Show

Allelic Composition: Nr3c1tm2.1Gsc/Nr3c1tm2.1Gsc
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000032294 Pkm / P52480 / Pyruvate kinase PKM / P14618* / pyruvate kinase M1/2*  / complex






 

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