ENSMUSG00000041237


Mus musculus

Features
Gene ID: ENSMUSG00000041237
  
Biological name :Pklr
  
Synonyms : Pklr / pyruvate kinase L/R
  
Possible biological names infered from orthology : P30613
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: F1
Gene start: 89136142
Gene end: 89146784
  
Corresponding Affymetrix probe sets: 10493382 (MoGene1.0st)   1421258_a_at (Mouse Genome 430 2.0 Array)   1421259_at (Mouse Genome 430 2.0 Array)   1438711_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000103106
Ensembl peptide - ENSMUSP00000119392
Ensembl peptide - ENSMUSP00000035417
NCBI entrez gene - 18770     See in Manteia.
MGI - MGI:97604
RefSeq - XM_006501135
RefSeq - NM_001099779
RefSeq - NM_013631
RefSeq - XM_006501134
RefSeq Peptide - NP_001093249
RefSeq Peptide - NP_038659
swissprot - E9Q509
swissprot - G3X925
swissprot - D3Z2C4
Ensembl - ENSMUSG00000041237
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pklrENSDARG00000042010Danio rerio
 PKLRENSG00000143627Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pkm / P52480 / Pyruvate kinase PKM / P14618* / pyruvate kinase M1/2*ENSMUSG0000003229464


Protein motifs (from Interpro)
Interpro ID Name
 IPR001697  Pyruvate kinase
 IPR011037  Pyruvate kinase-like, insert domain superfamily
 IPR015793  Pyruvate kinase, barrel
 IPR015795  Pyruvate kinase, C-terminal
 IPR015813  Pyruvate/Phosphoenolpyruvate kinase-like domain superfamily
 IPR018209  Pyruvate kinase, active site
 IPR036918  Pyruvate kinase, C-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0006096 glycolytic process IEA
 biological_processGO:0006754 ATP biosynthetic process IEA
 biological_processGO:0007584 response to nutrient IEA
 biological_processGO:0009408 response to heat IEA
 biological_processGO:0009749 response to glucose IEA
 biological_processGO:0010038 response to metal ion IEA
 biological_processGO:0010226 response to lithium ion IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0032869 cellular response to insulin stimulus IEA
 biological_processGO:0033198 response to ATP IEA
 biological_processGO:0042866 pyruvate biosynthetic process IEA
 biological_processGO:0051591 response to cAMP IEA
 biological_processGO:0071872 cellular response to epinephrine stimulus IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004743 pyruvate kinase activity IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0030955 potassium ion binding IEA


Pathways (from Reactome)
Pathway description
Glycolysis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pklrslc/Pklrslc
Genetic Background: CBA/NSlc-Pklrslc

 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Cntnap1tm1Pele/Cntnap1tm1Pele
Genetic Background: Not Specified

Allelic Composition: Pklrslc/Pklrslc
Genetic Background: CBA/NSlc-Pklrslc

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cntnap1tm1Pele/Cntnap1tm1Pele
Genetic Background: Not Specified

Allelic Composition: Pklrslc/Pklrslc
Genetic Background: CBA/NSlc-Pklrslc

Allelic Composition: Ampd3tm1Tm/Ampd3tm1Tm,Pklrslc/Pklrslc
Genetic Background: involves: CBA/NSlc

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Cntnap1tm1Pele/Cntnap1tm1Pele
Genetic Background: Not Specified

Allelic Composition: Pklrslc/Pklrslc
Genetic Background: CBA/NSlc-Pklrslc

Allelic Composition: Ampd3tm1Tm/Ampd3tm1Tm,Pklrslc/Pklrslc
Genetic Background: involves: CBA/NSlc

Allelic Composition: Pklrslc/Pklrslc
Genetic Background: involves: CBA/NSlc

 MP:0001585 hemolytic anemia "an anemic condition resulting from an increased rate of erythrocyte destruction" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cntnap1tm1Pele/Cntnap1tm1Pele
Genetic Background: Not Specified

Allelic Composition: Pklrslc/Pklrslc
Genetic Background: CBA/NSlc-Pklrslc

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pdpk1tm1Maka/Pdpk1tm1Maka,Tg(CAG-cat-lacZ)11Miya/0,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2 * FVB/N

 MP:0002447 abnormal erythrocyte morphology "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cntnap1tm1Pele/Cntnap1tm1Pele
Genetic Background: Not Specified

Allelic Composition: Ampd3tm1Tm/Ampd3tm1Tm,Pklrslc/Pklrslc
Genetic Background: involves: CBA/NSlc

Allelic Composition: Pklrslc/Pklrslc
Genetic Background: involves: CBA/NSlc

 MP:0002590 increased mean corpuscular volume "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pklrslc/Pklrslc
Genetic Background: CBA/NSlc-Pklrslc

 MP:0002640 reticulocytosis "an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Cntnap1tm1Pele/Cntnap1tm1Pele
Genetic Background: Not Specified

Allelic Composition: Pklrslc/Pklrslc
Genetic Background: CBA/NSlc-Pklrslc

Allelic Composition: Ampd3tm1Tm/Ampd3tm1Tm,Pklrslc/Pklrslc
Genetic Background: involves: CBA/NSlc

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cntnap1tm1Pele/Cntnap1tm1Pele
Genetic Background: Not Specified

Allelic Composition: Pklrslc/Pklrslc
Genetic Background: CBA/NSlc-Pklrslc

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pklrslc/Pklrslc
Genetic Background: CBA/NSlc-Pklrslc

 MP:0003135 increased erythrocyte precursors "greater numbers of progenitors of the erythrocyte lineage" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Pklrslc/Pklrslc
Genetic Background: CBA/NSlc-Pklrslc

 MP:0003656 abnormal erythrocyte physiology "functional anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ampd3tm1Tm/Ampd3tm1Tm,Pklrslc/Pklrslc
Genetic Background: involves: CBA/NSlc

 MP:0003657 abnormal erythrocyte lysis "increase or decrease in the ability of RBCs to withstand changes in osmolarity" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ampd3tm1Tm/Ampd3tm1Tm,Pklrslc/Pklrslc
Genetic Background: involves: CBA/NSlc

Allelic Composition: Pklrslc/Pklrslc
Genetic Background: involves: CBA/NSlc

 MP:0005026 decreased susceptibility to parasitic infection "reduced likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cntnap1tm1Pele/Cntnap1tm1Pele
Genetic Background: Not Specified

Allelic Composition: Pklrslc/Pklrslc
Genetic Background: CBA/NSlc-Pklrslc

 MP:0005344 increased circulating bilirubin level "greater than the normal concentration in the blood of this yellow heme breakdown product" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
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Allelic Composition: Pklrslc/Pklrslc
Genetic Background: CBA/NSlc-Pklrslc

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pklrslc/Pklrslc
Genetic Background: CBA/NSlc-Pklrslc

 MP:0005639 hemosiderosis "condition in which there is a generalized increase in the iron stores of body tissues, particularly of liver and the reticuloendothelial system, without demonstrable tissue damage" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pklrslc/Pklrslc
Genetic Background: CBA/NSlc-Pklrslc

 MP:0006410 abnormal common myeloid progenitor cell morphology "anomaly in the structure of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Pklrslc/Pklrslc
Genetic Background: CBA/NSlc-Pklrslc

 MP:0009395 persistence of primitive erythrocytes "presence of increased numbers of nucleated red blood cells at stages when these cells are normally replaced by mature, enucleated, red blood cells" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Pklrslc/Pklrslc
Genetic Background: CBA/NSlc-Pklrslc

 MP:0009788 increased susceptibility to bacterial infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Pklrslc/Pklrslc
Genetic Background: CBA/NSlc-Pklrslc

 MP:0010035 increased erythrocyte clearance "increased elimination of aging erythrocytes from the body by autoregulatory mechanisms, often expressed as half-life" [GO:0034102, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cntnap1tm1Pele/Cntnap1tm1Pele
Genetic Background: Not Specified

Allelic Composition: Pklrslc/Pklrslc
Genetic Background: CBA/NSlc-Pklrslc

 MP:0010751 decreased susceptibility to parasitic infection induced morbidity/mortality "decreased likelihood that an organism will display the expected moribund state caused by a parasitic invasion or from components of or toxins produced by parasites" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cntnap1tm1Pele/Cntnap1tm1Pele
Genetic Background: Not Specified

Allelic Composition: Pklrslc/Pklrslc
Genetic Background: CBA/NSlc-Pklrslc

 MP:0011178 increased erythroblast number "greater number of the nucleated precursor of erythrocytes" [MGI:csmith]
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Allelic Composition: Pklrslc/Pklrslc
Genetic Background: CBA/NSlc-Pklrslc

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000041237 Pklr / pyruvate kinase L/R / P30613*  / complex






 

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