ENSG00000069482


Homo sapiens

Features
Gene ID: ENSG00000069482
  
Biological name :GAL
  
Synonyms : GAL / galanin and GMAP prepropeptide / P22466
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: q13.2
Gene start: 68683779
Gene end: 68691175
  
Corresponding Affymetrix probe sets: 207466_at (Human Genome U133 Plus 2.0 Array)   214240_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000265643
NCBI entrez gene - 51083     See in Manteia.
OMIM - 137035
RefSeq - NM_015973
RefSeq Peptide - NP_057057
swissprot - P22466
Ensembl - ENSG00000069482
  
Related genetic diseases (OMIM): 616461 - ?Epilepsy, familial temporal lobe, 8, 616461
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 galnENSDARG00000091377Danio rerio
 GALENSGALG00000007047Gallus gallus
 GalENSMUSG00000024907Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR008174  Galanin
 IPR008175  Galanin precursor
 IPR013068  Galanin message associated peptide (GMAP)


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007218 neuropeptide signaling pathway IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007631 feeding behavior IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010737 protein kinase A signaling IDA
 biological_processGO:0019933 cAMP-mediated signaling IDA
 biological_processGO:0030073 insulin secretion NAS
 biological_processGO:0031943 regulation of glucocorticoid metabolic process IEA
 biological_processGO:0032868 response to insulin IEA
 biological_processGO:0035902 response to immobilization stress IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043627 response to estrogen IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0050672 negative regulation of lymphocyte proliferation IEA
 biological_processGO:0051464 positive regulation of cortisol secretion IDA
 biological_processGO:0051795 positive regulation of timing of catagen IDA
 biological_processGO:1902608 positive regulation of large conductance calcium-activated potassium channel activity IDA
 biological_processGO:1902891 negative regulation of root hair elongation IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0030141 secretory granule IEA
 cellular_componentGO:0043025 neuronal cell body IDA
 molecular_functionGO:0004966 galanin receptor activity IMP
 molecular_functionGO:0005179 hormone activity IEA
 molecular_functionGO:0005184 neuropeptide hormone activity NAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031764 type 1 galanin receptor binding IDA
 molecular_functionGO:0031765 type 2 galanin receptor binding IDA
 molecular_functionGO:0031766 type 3 galanin receptor binding IDA


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000006 Autosomal dominant inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele." [HPO:curators]
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 HP:0002384 Complex partial seizures "A `partial seizure` (HP:0007359) characterized by impairment or loss of consciousness." [HPO:curators]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000166573 GALR1 / P47211 / galanin receptor 1  / reaction / complex
 ENSG00000128310 GALR3 / O60755 / galanin receptor 3  / reaction / complex
 ENSG00000182687 GALR2 / O43603 / galanin receptor 2  / reaction / complex






 

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